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ChemicalBook >> CAS DataBase List >> IWP L6

IWP L6

IWP L6 price.
  • $31 - $2245.7
  • Product name: IWP L6
  • CAS: 1427782-89-5
  • MF: C25H20N4O2S2
  • MW: 472.58
  • EINECS:-0
  • MDL Number:MFCD27937771
  • Synonyms:IWP L6;2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyriMidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetaMide;N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide;Porcn Inhibitor III;N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide IWP-L6;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide;IWP-L6, >=98%;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl
Price47 Properties Safety Information Description
47 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 250mg
  • 1000mg
  • 10mM*1mLinDMSO(Solution)
  • 10mM*1mLinDMSO
  • 50
  • 10
  • 1g
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 5mg
  • 10mM(in1mLDMSO)
  • 10mg
  • 25mg
  • 50mg
  • 100MG
  • 10mM(in 1mL DMSO)
  • Manufactureraablocks
  • Product numberAA009C9O
  • Product description2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 99%
  • Packaging5mg
  • Price$31
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C9O
  • Product description2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 99%
  • Packaging10mg
  • Price$46
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C9O
  • Product description2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 99%
  • Packaging25mg
  • Price$96
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C9O
  • Product description2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 99%
  • Packaging50mg
  • Price$145
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberZ238524
  • Product descriptionIWP L6 98%
  • Packaging100MG
  • Price$525
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberZ238524
  • Product descriptionIWP L6 98%
  • Packaging25MG
  • Price$135
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number2487AH
  • Product description2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide
  • Packaging5mg
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2487AH
  • Product description2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide
  • Packaging10mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2305
  • Product descriptionIWP-L6
  • Packaging50mg
  • Price$330
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2305
  • Product descriptionIWP-L6
  • Packaging10mg
  • Price$105
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2305
  • Product descriptionIWP-L6
  • Packaging10mM(in1mLDMSO)
  • Price$110
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2305
  • Product descriptionIWP-L6
  • Packaging10mM(in 1mL DMSO)
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S7301
  • Product descriptionIWP-L6 99.52%
  • Packaging10mg
  • Price$140
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-15825
  • Product descriptionIWPL6 98.71%
  • Packaging10mM*1mLinDMSO(Solid+Solvent)
  • Price$50
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-15825
  • Product descriptionIWPL6 98.71%
  • Packaging5mg
  • Price$51
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-15825
  • Product descriptionIWPL6 98.71%
  • Packaging10mM*1mLinDMSO(Solution)
  • Price$53
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009C9O 2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 99% 5mg $31 2026-05-28 Buy
aablocks AA009C9O 2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 99% 10mg $46 2026-05-28 Buy
aablocks AA009C9O 2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 99% 25mg $96 2026-05-28 Buy
aablocks AA009C9O 2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 99% 50mg $145 2026-05-28 Buy
ACHEMBLOCK Z238524 IWP L6 98% 100MG $525 2026-05-27 Buy
ACHEMBLOCK Z238524 IWP L6 98% 25MG $135 2026-05-27 Buy
AK Scientific 2487AH 2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 5mg $138 2021-12-16 Buy
AK Scientific 2487AH 2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 10mg $190 2021-12-16 Buy
ApexBio Technology B2305 IWP-L6 50mg $330 2026-05-06 Buy
ApexBio Technology B2305 IWP-L6 10mg $105 2026-05-06 Buy
ApexBio Technology B2305 IWP-L6 10mM(in1mLDMSO) $110 2026-05-06 Buy
ApexBio Technology B2305 IWP-L6 10mM(in 1mL DMSO) $130 2021-12-16 Buy
Arctom SLK-S7301 IWP-L6 99.52% 10mg $140 2026-05-26 Buy
Arctom HY-15825 IWPL6 98.71% 10mM*1mLinDMSO(Solid+Solvent) $50 2026-05-26 Buy
Arctom HY-15825 IWPL6 98.71% 5mg $51 2026-05-26 Buy
Arctom HY-15825 IWPL6 98.71% 10mM*1mLinDMSO(Solution) $53 2026-05-26 Buy
Next Last

Properties

storage temp. :Store at -20° C
solubility :≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
color :White to off-white
InChI :1S/C25H20N4O2S2/c30-22(28-21-12-11-18(15-26-21)17-7-3-1-4-8-17)16-33-25-27-20-13-14-32-23(20)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,26,28,30)
InChIKey :QESQGTFWEQMCMH-UHFFFAOYSA-N

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. IWP-L6 is a potent inhibitor of PORCN (EC50 = 0.5 nM). It suppresses the phosphorylation of disheveled 2 in HEK293 cells. IWP-L6 displays high stability in human plasma (t1/2 > 24 hours) and in zebrafish, but it is much less stable in plasma from mice and rats. In zebrafish, IWP-L6 blocks Wnt/β-catenin-dependent developmental processes, including tailfin regeneration and posterior axis formation. It also completely prevents branching morphogenesis in cultured mouse embryonic kidneys at doses of 50 nM and above, indicating complete inhibition of Wnt signaling.

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Suppliers and manufacturers

career henan chemical co
2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide
$1.00
2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide CAS:1427782-89-5
TargetMol Chemicals Inc.
IWP L6
$41.00
IWP L6 CAS:1427782-89-5
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
Zhengzhou Anbu Chem Co.,Ltd
Zibo Hangyu Biotechnology Development Co., Ltd
Aladdin Scientific
Amadis Chemical Company Limited BOC Sciences Dalian Meilun Biotech Co., Ltd.