LGK-974
|
- $16 - $4090
- Product name: LGK-974
- CAS: 1243244-14-5
- MF: C23H20N6O
- MW: 396.44
- EINECS:
- MDL Number:MFCD27501026
- Synonyms:LGK974(NVP-LGK974);2-[5-Methyl-6-(2-methyl-4-pyridyl)-3-pyridyl]-N-(5-pyrazin-2-yl-2-pyridyl)acetamide;LGK-974;2-(2',3-diMethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetaMide;2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide;[2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-;NVP-LGK974;LGK-974 2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide
65 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- 500μg
- 10mM(in 1mL DMSO)
- 250mg
- 10mM*1mLinDMSO
- 1.00g
- 1000mg
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA000LRI
- Product description2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide 99%(HPLC)
- Packaging1mg
- Price$16
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000LRI
- Product description2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide 99%(HPLC)
- Packaging5mg
- Price$34
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000LRI
- Product description2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide 99%(HPLC)
- Packaging10mg
- Price$49
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000LRI
- Product description2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide 99%(HPLC)
- Packaging25mg
- Price$82
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000LRI
- Product description2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide 99%(HPLC)
- Packaging50mg
- Price$126
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000LRI
- Product description2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide 99%(HPLC)
- Packaging100mg
- Price$201
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberX217586
- Product descriptionLGK-974 (WNT974) 98%
- Packaging25MG
- Price$380
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX217586
- Product descriptionLGK-974 (WNT974) 98%
- Packaging50MG
- Price$685
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX217586
- Product descriptionLGK-974 (WNT974) 98%
- Packaging100MG
- Price$980
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2140AH
- Product description2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
- Packaging1g
- Price$4090
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2307
- Product descriptionLGK-974
- Packaging50mg
- Price$704
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB2307
- Product descriptionLGK-974
- Packaging50mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2307
- Product descriptionLGK-974
- Packaging10mM(in1mLDMSO)
- Price$127
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB2307
- Product descriptionLGK-974
- Packaging10mM(in 1mL DMSO)
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2307
- Product descriptionLGK-974
- Packaging5mg
- Price$121
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB2307
- Product descriptionLGK-974
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000LRI | 2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide 99%(HPLC) | 1mg | $16 | 2026-05-25 | Buy |
| aablocks | AA000LRI | 2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide 99%(HPLC) | 5mg | $34 | 2026-05-25 | Buy |
| aablocks | AA000LRI | 2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide 99%(HPLC) | 10mg | $49 | 2026-05-25 | Buy |
| aablocks | AA000LRI | 2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide 99%(HPLC) | 25mg | $82 | 2026-05-25 | Buy |
| aablocks | AA000LRI | 2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide 99%(HPLC) | 50mg | $126 | 2026-05-25 | Buy |
| aablocks | AA000LRI | 2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide 99%(HPLC) | 100mg | $201 | 2026-05-25 | Buy |
| ACHEMBLOCK | X217586 | LGK-974 (WNT974) 98% | 25MG | $380 | 2026-05-27 | Buy |
| ACHEMBLOCK | X217586 | LGK-974 (WNT974) 98% | 50MG | $685 | 2026-05-27 | Buy |
| ACHEMBLOCK | X217586 | LGK-974 (WNT974) 98% | 100MG | $980 | 2026-05-27 | Buy |
| AK Scientific | 2140AH | 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide | 1g | $4090 | 2021-12-16 | Buy |
| ApexBio Technology | B2307 | LGK-974 | 50mg | $704 | 2026-05-06 | Buy |
| ApexBio Technology | B2307 | LGK-974 | 50mg | $640 | 2021-12-16 | Buy |
| ApexBio Technology | B2307 | LGK-974 | 10mM(in1mLDMSO) | $127 | 2026-05-06 | Buy |
| ApexBio Technology | B2307 | LGK-974 | 10mM(in 1mL DMSO) | $140 | 2021-12-16 | Buy |
| ApexBio Technology | B2307 | LGK-974 | 5mg | $121 | 2026-05-06 | Buy |
| ApexBio Technology | B2307 | LGK-974 | 5mg | $110 | 2021-12-16 | Buy |
Properties
Melting point :176 - 180°C
Boiling point :650.9±55.0 °C(Predicted)
Density :1.268±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :12.24±0.70(Predicted)
form :Solid
color :White to Off-White
InChI :InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)
InChIKey :XXYGTCZJJLTAGH-UHFFFAOYSA-N
SMILES :C1(C2C=CN=C(C)C=2)=NC=C(CC(NC2=NC=C(C3=NC=CN=C3)C=C2)=O)C=C1C
Boiling point :650.9±55.0 °C(Predicted)
Density :1.268±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :12.24±0.70(Predicted)
form :Solid
color :White to Off-White
InChI :InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)
InChIKey :XXYGTCZJJLTAGH-UHFFFAOYSA-N
SMILES :C1(C2C=CN=C(C)C=2)=NC=C(CC(NC2=NC=C(C3=NC=CN=C3)C=C2)=O)C=C1C
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK974 is a potent and specific small molecule inhibitor of PORCN (IC50 = 0.4 nM). It greatly reduces Wnt secretion without decreasing its synthesis and without increasing cytotoxicity. LGK974 is orally bioavailable in mice and induces tumor regression in mouse breast tumors produced by mammary tumor virus-driven Wnt1 signaling. It also blocks carcinogenesis in other Wnt-related tumors at doses that have limited impact on stem cell renewal.Related product price
-
Olaparib
$11-2147.1 -
252917-06-9
$28-4401 -
Sunitinib Malate
$6-1593.9
Suppliers and manufacturers
Shaanxi Haibo Biotechnology Co., Ltd
ATK CHEMICAL COMPANY LIMITED
Biochempartner
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Dideu Industries Group Limited
Hefei Hirisun Pharmatech Co., Ltd
Zhejiang J&C Biological Technology Co.,Limited
Labnetwork lnc.
LGK-974
CAS:1243244-14-5
