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ChemicalBook >> CAS DataBase List >> KM 233

KM 233

KM 233 price.
  • $63 - $1062
  • Product name: KM 233
  • CAS: 628263-22-9
  • MF: C25H30O2
  • MW: 362.5
  • EINECS:
  • MDL Number:
  • Synonyms:KM 233;6H-Dibenzo[b,d]pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-(1-methyl-1-phenylethyl)-, (6aR,10aR)-
4 prices
Selected condition:
Brand
  • Cayman Chemical
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • ManufacturerCayman Chemical
  • Product number10640
  • Product descriptionKM 233 ≥98%
  • Packaging1mg
  • Price$63
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10640
  • Product descriptionKM 233 ≥98%
  • Packaging5mg
  • Price$275
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10640
  • Product descriptionKM 233 ≥98%
  • Packaging10mg
  • Price$486
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10640
  • Product descriptionKM 233 ≥98%
  • Packaging25mg
  • Price$1062
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 10640 KM 233 ≥98% 1mg $63 2024-03-01 Buy
Cayman Chemical 10640 KM 233 ≥98% 5mg $275 2024-03-01 Buy
Cayman Chemical 10640 KM 233 ≥98% 10mg $486 2024-03-01 Buy
Cayman Chemical 10640 KM 233 ≥98% 25mg $1062 2024-03-01 Buy

Properties

storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 20 mg/ml; Ethanol: 3 mg/ml
form :A crystalline solid

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Because selective activation of peripheral cannabinoid (CB2) receptors in rat C-6 glioma cells has been shown to induce apoptosis through enhanced ceramide synthesis de novo, CB2 agonists present potential as anti glioma agents. KM 233 is a Δ8-tetrahydrocannabinol analog with a dimethyl substitution that exhibits high binding affinity for both the CB1 and CB2 receptors with 13-fold selectivity for the CB2 receptor (Kis = 12.3 and 0.91 nM, respectively). Demonstrating good lipophilicity and ability to penetrate the blood brain barrier, KM 233 inhibits human U87 glioma cell proliferation in vitro with an IC50 value of 1.4 μM and significantly reduces U87 glioma tumor size in vivo at a dose of 2 mg/kg in a SCID mouse xenograft side-pocket model.