Ki8751
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- $20 - $1802
- Product name: Ki8751
- CAS: 228559-41-9
- MF: C24H18F3N3O4
- MW: 469.41
- EINECS:
- MDL Number:MFCD09971092
- Synonyms:Ki8751 hydrate;Ki8751, >=98%;KI8751;KI 8751;KI-8751;VEGFR2 Kinase Inhibitor VI, Ki8751 ;Ki8751;1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluoro-phenyl]-urea hydrate;N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea;1-(2,4-difluorophenyl)-3-(4-(6,7-diMethoxyquinolin-4-yloxy)-2-fluorophenyl)urea
54 prices
Selected condition：
Brand
- aablocks
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10.00mg
- 10
- 10mg
- 25mg
- 25.00mg
- 50
- 50mg
- 50.00mg
- 100mg
- 250mg
- 10mM(in1mLDMSO)
- 1g
- 10mM*1mLinDMSO
- 1000mg
- Manufactureraablocks
- Product numberAA00BF17
- Product descriptionN-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99%
- Packaging1mg
- Price$31
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF17
- Product descriptionN-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99%
- Packaging5mg
- Price$38
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF17
- Product descriptionN-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99%
- Packaging10mg
- Price$59
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF17
- Product descriptionN-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99%
- Packaging25mg
- Price$87
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF17
- Product descriptionN-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99%
- Packaging50mg
- Price$107
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF17
- Product descriptionN-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99%
- Packaging100mg
- Price$128
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF17
- Product descriptionN-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99%
- Packaging250mg
- Price$225
- Updated2026-05-28
- Buy
- ManufacturerAK Scientific
- Product numberJ53091
- Product descriptionKI8751
- Packaging25mg
- Price$202
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7488
- Product descriptionKI8751
- Packaging10mg
- Price$123
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7488
- Product descriptionKI8751
- Packaging5mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7488
- Product descriptionKI8751
- Packaging50mg
- Price$505
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA187238
- Product descriptionKi8751 98+%
- Packaging1g
- Price$351
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA187238
- Product descriptionKi8751 98+%
- Packaging5mg
- Price$20
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA187238
- Product descriptionKi8751 98+%
- Packaging10mg
- Price$26
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA187238
- Product descriptionKi8751 98+%
- Packaging50mg
- Price$44
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA187238
- Product descriptionKi8751 98+%
- Packaging100mg
- Price$71
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00BF17 | N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99% | 1mg | $31 | 2026-05-28 | Buy |
| aablocks | AA00BF17 | N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99% | 5mg | $38 | 2026-05-28 | Buy |
| aablocks | AA00BF17 | N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99% | 10mg | $59 | 2026-05-28 | Buy |
| aablocks | AA00BF17 | N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99% | 25mg | $87 | 2026-05-28 | Buy |
| aablocks | AA00BF17 | N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99% | 50mg | $107 | 2026-05-28 | Buy |
| aablocks | AA00BF17 | N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99% | 100mg | $128 | 2026-05-28 | Buy |
| aablocks | AA00BF17 | N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea 99% | 250mg | $225 | 2026-05-28 | Buy |
| AK Scientific | J53091 | KI8751 | 25mg | $202 | 2021-12-16 | Buy |
| AK Scientific | X7488 | KI8751 | 10mg | $123 | 2021-12-16 | Buy |
| AK Scientific | X7488 | KI8751 | 5mg | $75 | 2021-12-16 | Buy |
| AK Scientific | X7488 | KI8751 | 50mg | $505 | 2021-12-16 | Buy |
| Ambeed | A187238 | Ki8751 98+% | 1g | $351 | 2021-12-16 | Buy |
| Ambeed | A187238 | Ki8751 98+% | 5mg | $20 | 2021-12-16 | Buy |
| Ambeed | A187238 | Ki8751 98+% | 10mg | $26 | 2021-12-16 | Buy |
| Ambeed | A187238 | Ki8751 98+% | 50mg | $44 | 2021-12-16 | Buy |
| Ambeed | A187238 | Ki8751 98+% | 100mg | $71 | 2021-12-16 | Buy |
Properties
Melting point :239℃
Density :1.429
storage temp. :−20°C
solubility :Soluble in DMSO (15 mg/ml)
form :Off-white solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
InChIKey :LFKQSJNCVRGFCC-UHFFFAOYSA-N
SMILES :Fc1c(ccc(c1)F)NC(=O)Nc2c(cc(cc2)Oc3c4c(ncc3)cc(c(c4)OC)OC)F
Density :1.429
storage temp. :−20°C
solubility :Soluble in DMSO (15 mg/ml)
form :Off-white solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
InChIKey :LFKQSJNCVRGFCC-UHFFFAOYSA-N
SMILES :Fc1c(ccc(c1)F)NC(=O)Nc2c(cc(cc2)Oc3c4c(ncc3)cc(c(c4)OC)OC)F
Safety Information
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| Precautionary statements: |
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Description
Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. Ki8751 is a potent, orally available inhibitor of the kinase activity of VEGFR2 (IC50 = 0.9 nM). It less potently inhibits c-Kit, PDGRFα, and FGFR2 (IC50s = 40-170 nM) and has no significant effect against several other receptor tyrosine kinases. Ki8751 suppresses the growth of VEGF-stimulated human umbilical vein endothelial cells at nanomolar concentrations. It shows significant anti-tumor activity against assorted human tumor xenografts in nude mice. Ki8751 also induces cellular senescence in colorectal cancer cells.More related product prices
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Suppliers and manufacturers
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