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ChemicalBook >> CAS DataBase List >> LB 42708

LB 42708

LB 42708 price.
  • $40 - $2691.1
  • Product name: LB 42708
  • CAS: 226929-39-1
  • MF: C30H27BrN4O2
  • MW: 555.47
  • EINECS:
  • MDL Number:MFCD20926350
  • Synonyms:LB 42708;[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinylmethanone;[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinylmethanone LB42708;4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine;[1-{[1-(4-bromobenzyl)-1h-imidazol-5-yl]methyl}-4-(1-naphthyl)-1h -pyrrol-3-yl](4-morpholinyl)methanone;LB-42708;LB 42708;CS-1450;Methanone, [1-[[1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinyl-
Price51 Properties Safety Information Description
51 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 10mM(in 1mL DMSO)
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 2x25mg
  • 100mg
  • 250mg
  • 1g
  • 1000mg
  • 10mM(in1mLDMSO)
  • Manufactureraablocks
  • Product numberAA003989
  • Product description4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine 98
  • Packaging1mg
  • Price$48
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003989
  • Product description4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine 98
  • Packaging5mg
  • Price$78
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003989
  • Product description4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine 98%
  • Packaging10mg
  • Price$79
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003989
  • Product description4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine 98%
  • Packaging25mg
  • Price$160
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003989
  • Product description4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine 98%
  • Packaging50mg
  • Price$240
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003989
  • Product description4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine 98
  • Packaging100mg
  • Price$418
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY227618
  • Product descriptionLB42708 97.00%
  • Packaging25MG
  • Price$270
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY227618
  • Product descriptionLB42708 97.00%
  • Packaging100MG
  • Price$595
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number2507AH
  • Product description(1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone
  • Packaging10mg
  • Price$313
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2507AH
  • Product description(1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone
  • Packaging5mg
  • Price$229
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2507AH
  • Product description(1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone
  • Packaging1mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001275
  • Product description[1-[[1-[(4-BROMOPHENYL)METHYL]-1H-IMIDAZOL-5-YL]METHYL]-4-(1-NAPHTHALENYL)-1H-PYRROL-3-YL]-4-MORPHOLINYLMETHANONE 95.00%
  • Packaging5MG
  • Price$480
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001275
  • Product description[1-[[1-[(4-BROMOPHENYL)METHYL]-1H-IMIDAZOL-5-YL]METHYL]-4-(1-NAPHTHALENYL)-1H-PYRROL-3-YL]-4-MORPHOLINYLMETHANONE 95.00%
  • Packaging10MG
  • Price$545
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001275
  • Product description[1-[[1-[(4-BROMOPHENYL)METHYL]-1H-IMIDAZOL-5-YL]METHYL]-4-(1-NAPHTHALENYL)-1H-PYRROL-3-YL]-4-MORPHOLINYLMETHANONE 95.00%
  • Packaging50MG
  • Price$1050
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3703
  • Product descriptionLB42708
  • Packaging10mg
  • Price$131
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3703
  • Product descriptionLB42708
  • Packaging10mM(in1mLDMSO)
  • Price$99
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA003989 4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine 98 1mg $48 2026-05-28 Buy
aablocks AA003989 4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine 98 5mg $78 2026-05-28 Buy
aablocks AA003989 4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine 98% 10mg $79 2026-05-28 Buy
aablocks AA003989 4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine 98% 25mg $160 2026-05-28 Buy
aablocks AA003989 4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine 98% 50mg $240 2026-05-28 Buy
aablocks AA003989 4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine 98 100mg $418 2026-05-28 Buy
ACHEMBLOCK Y227618 LB42708 97.00% 25MG $270 2026-05-27 Buy
ACHEMBLOCK Y227618 LB42708 97.00% 100MG $595 2026-05-27 Buy
AK Scientific 2507AH (1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone 10mg $313 2021-12-16 Buy
AK Scientific 2507AH (1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone 5mg $229 2021-12-16 Buy
AK Scientific 2507AH (1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone 1mg $147 2021-12-16 Buy
American Custom Chemicals Corporation INB0001275 [1-[[1-[(4-BROMOPHENYL)METHYL]-1H-IMIDAZOL-5-YL]METHYL]-4-(1-NAPHTHALENYL)-1H-PYRROL-3-YL]-4-MORPHOLINYLMETHANONE 95.00% 5MG $480 2021-12-16 Buy
American Custom Chemicals Corporation INB0001275 [1-[[1-[(4-BROMOPHENYL)METHYL]-1H-IMIDAZOL-5-YL]METHYL]-4-(1-NAPHTHALENYL)-1H-PYRROL-3-YL]-4-MORPHOLINYLMETHANONE 95.00% 10MG $545 2021-12-16 Buy
American Custom Chemicals Corporation INB0001275 [1-[[1-[(4-BROMOPHENYL)METHYL]-1H-IMIDAZOL-5-YL]METHYL]-4-(1-NAPHTHALENYL)-1H-PYRROL-3-YL]-4-MORPHOLINYLMETHANONE 95.00% 50MG $1050 2021-12-16 Buy
ApexBio Technology B3703 LB42708 10mg $131 2026-05-06 Buy
ApexBio Technology B3703 LB42708 10mM(in1mLDMSO) $99 2026-05-06 Buy
Next Last

Properties

Boiling point :769.6±60.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥22.75 mg/mL in DMSO; insoluble in H2O; ≥47.5 mg/mL in EtOH
pka :5.67±0.13(Predicted)
form :solid
color :Off-white to light yellow

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Farnesylation, the post-translational addition of a 15-carbon isoprenyl group, alters the function of several proteins, including Ras proteins. LB 42708 is a potent inhibitor of farnesyltransferase (FTase), blocking farnesylation of H-Ras, N-Ras, and K-Ras4B with IC50 values of 0.8, 1.2, and 2.0 nM, respectively. It displays over 50,000-fold selectivity for FTase over geranylgeranyltransferase I. LB 42708 prevents the farnesylation of H-Ras in response to LPS plus IFN-γ (IC50 = 10 nM), preventing activation of NF-κB as well as downstream signaling. These effects are obtained both in RAW 264.7 mouse macrophages and in mice. LB42708 also inhibits Ras-dependent signaling in endothelial cells, stopping VEGF-mediated angiogenesis both in vitro and in vivo.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
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$34.00
LB42708 CAS:226929-39-1
Shaanxi Dideu New Materials Co. Ltd
LB 42708
LB 42708 CAS:226929-39-1
Dideu Industries Group Limited
HANGZHOU LEAP CHEM CO., LTD.
Aladdin Scientific
Amadis Chemical Company Limited BOC Sciences Shanghai Lollane Biological Technology Co.,Ltd. Chengdu Chuangkecheng Biological Technology Co., Ltd. Shanghai EFE Biological Technology Co., Ltd.