Capivasertib
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- $14 - $2839
- Product name: Capivasertib
- CAS: 1143532-39-1
- MF: C21H25ClN6O2
- MW: 428.92
- EINECS:
- MDL Number:MFCD22628785
- Synonyms:AZD5356;4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide AZD5363;AZD 5363 dihydrochloride;AZD5363;AZD-5363;AZD 5363;(S)-4-Amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidi;AZD5363, 99%, a potent pan-AKT kinase inhibitor;AZD5636;AZD5363(Capivasertib)
64 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Synthonix
- Tocris
- TRC
- Usbiological
Package
- 2mg
- 10mM*1mLinDMSO
- 10.00mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 25.00mg
- 25
- 50.00mg
- 500mg
- 5
- 1000mg
- 10mM*1mLinDMSO(Solution)
- 1mg
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA000B1W
- Product descriptionAZD5363 98%
- Packaging1mg
- Price$14
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000B1W
- Product descriptionAZD5363 98%
- Packaging5mg
- Price$28
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000B1W
- Product descriptionAZD5363 98%
- Packaging10mg
- Price$41
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000B1W
- Product descriptionAZD5363 98%
- Packaging25mg
- Price$80
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000B1W
- Product descriptionAZD5363 98%
- Packaging50mg
- Price$121
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000B1W
- Product descriptionAZD5363 98%
- Packaging100mg
- Price$181
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000B1W
- Product descriptionAZD5363 98%
- Packaging250mg
- Price$255
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000B1W
- Product descriptionAZD5363 >97%
- Packaging1g
- Price$750
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberY230696
- Product description(S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 98%
- Packaging1G
- Price$785
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY230696
- Product description(S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 98%
- Packaging100MG
- Price$155
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2241AH
- Product descriptionAZD5363
- Packaging1mg
- Price$116
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1387
- Product descriptionAZD5363
- Packaging5mg
- Price$69
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1387
- Product descriptionAZD5363
- Packaging25mg
- Price$234
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1387
- Product descriptionAZD5363
- Packaging100mg
- Price$642
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-15431
- Product descriptionCapivasertib 99.96%
- Packaging200mg
- Price$689
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15431
- Product descriptionCapivasertib 99.96%
- Packaging50mg
- Price$342
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000B1W | AZD5363 98% | 1mg | $14 | 2026-05-25 | Buy |
| aablocks | AA000B1W | AZD5363 98% | 5mg | $28 | 2026-05-25 | Buy |
| aablocks | AA000B1W | AZD5363 98% | 10mg | $41 | 2026-05-25 | Buy |
| aablocks | AA000B1W | AZD5363 98% | 25mg | $80 | 2026-05-25 | Buy |
| aablocks | AA000B1W | AZD5363 98% | 50mg | $121 | 2026-05-25 | Buy |
| aablocks | AA000B1W | AZD5363 98% | 100mg | $181 | 2026-05-25 | Buy |
| aablocks | AA000B1W | AZD5363 98% | 250mg | $255 | 2026-05-25 | Buy |
| aablocks | AA000B1W | AZD5363 >97% | 1g | $750 | 2026-05-25 | Buy |
| ACHEMBLOCK | Y230696 | (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 98% | 1G | $785 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y230696 | (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 98% | 100MG | $155 | 2026-05-27 | Buy |
| AK Scientific | 2241AH | AZD5363 | 1mg | $116 | 2021-12-16 | Buy |
| ApexBio Technology | A1387 | AZD5363 | 5mg | $69 | 2026-05-06 | Buy |
| ApexBio Technology | A1387 | AZD5363 | 25mg | $234 | 2026-05-06 | Buy |
| ApexBio Technology | A1387 | AZD5363 | 100mg | $642 | 2026-05-06 | Buy |
| Arctom | HY-15431 | Capivasertib 99.96% | 200mg | $689 | 2026-05-26 | Buy |
| Arctom | HY-15431 | Capivasertib 99.96% | 50mg | $342 | 2026-05-26 | Buy |
Properties
Melting point :161-164°C
Density :1.381
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.93±0.50(Predicted)
form :Solid
color :Off-White to Pale Beige
InChIKey :JDUBGYFRJFOXQC-KRWDZBQOSA-N
SMILES :N1(C2N=CN=C3NC=CC3=2)CCC(N)(C(N[C@H](C2=CC=C(Cl)C=C2)CCO)=O)CC1
Density :1.381
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.93±0.50(Predicted)
form :Solid
color :Off-White to Pale Beige
InChIKey :JDUBGYFRJFOXQC-KRWDZBQOSA-N
SMILES :N1(C2N=CN=C3NC=CC3=2)CCC(N)(C(N[C@H](C2=CC=C(Cl)C=C2)CCO)=O)CC1
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Akt functions as a key component in multiple signaling pathways including those related to cell proliferation, metabolism, and survival as well as angiogenesis. AZD 5363 is a pyrrolopyrimidine-derived compound that inhibits Akt by competitively binding to the kinase domain, preventing substrate phosphorylation by Akt. It inhibits Akt1, 2, and 3 with IC50 values of 3, 7, and 7 nM, respectively and also inhibits P70S6K and PKA with similar potency (IC50s = 6 and 7 nM, respectively). Furthermore, AZD 5363 shows >75% inhibition at 1 μM against ROCK-II, MKK1, MSK1, MSK2, PKCγ, PKGα, PKGβ, PRKX, RSK2, and RSK3. At 3 μM or less, AZD 5363 has been reported to inhibit the proliferation of 41 out of 182 solid and hematologic tumor cell lines, demonstrating the greatest sensitivity towards breast cancer derived-cells or those with PIK3CA and/or PTEN mutations. Oral dosing to nude mice bearing BT474c xenografts resulted in antitumor activity, including the reduction of the phosphorylation of PRAS40, GSK3β, and S6 at an EC50 value of ~ 0.1 μM.More related product prices
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Suppliers and manufacturers
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