LDN-214117
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- $30 - $2841
- Product name: LDN-214117
- CAS: 1627503-67-6
- MF: C25H29N3O3
- MW: 419.52
- EINECS:
- MDL Number:MFCD28168043
- Synonyms:LDN-214117;1-(4-(6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine;1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine;LDN-214117;LDN214117;CS-1539;Piperazine, 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]-;LDN-214117 USP/EP/BP;LDN214117,LDN-214117,ALK2,BMP4,BMP2,Transforming growth factor beta receptors,LDN 214117,BMP6,TGF-β Receptor,diffuse intrinsic pontine glioma(DIPG),oral,ALK3,fibrodysplasia ossificans progressiva (FOP),ALK5,type I receptor kinases,ALK1,bone morphogenetic proteins (BMPs)
54 prices
Selected condition：
Brand
- aablocks
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 250mg
- 1g
- 5 mg
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO
- 50
- 10
- 25 mg
- 1mg
- 5mg
- 10mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 25mg
- 50mg
- 100mg
- 10mM(1mLinDMSO)
- Manufactureraablocks
- Product numberAA001TBA
- Product descriptionLDN-214117 98%
- Packaging10mg
- Price$70
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001TBA
- Product descriptionLDN-214117
- Packaging25mg
- Price$166
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001TBA
- Product descriptionLDN-214117
- Packaging50mg
- Price$270
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001TBA
- Product descriptionLDN-214117
- Packaging100mg
- Price$406
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001TBA
- Product descriptionLDN-214117 98%
- Packaging5mg
- Price$38
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001TBA
- Product descriptionLDN-214117 ≥98%
- Packaging1mg
- Price$36
- Updated2026-05-28
- Buy
- ManufacturerAmbeed
- Product numberA637146
- Product descriptionLDN-214117 98+%
- Packaging100mg
- Price$495
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA637146
- Product descriptionLDN-214117 98+%
- Packaging50mg
- Price$315
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA637146
- Product descriptionLDN-214117 98+%
- Packaging10mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA637146
- Product descriptionLDN-214117 98+%
- Packaging1mg
- Price$30
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA637146
- Product descriptionLDN-214117 98+%
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002514
- Product description1-(4-(6-METHYL-5-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-3-YL)PHENYL)PIPERAZINE 95.00%
- Packaging5MG
- Price$496.93
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4842
- Product descriptionLDN-214117
- Packaging100mg
- Price$595
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4842
- Product descriptionLDN-214117
- Packaging5mg
- Price$70
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4842
- Product descriptionLDN-214117
- Packaging25mg
- Price$245
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberSLK-S7627
- Product descriptionLDN-214117 99.97%
- Packaging25mg
- Price$330
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA001TBA | LDN-214117 98% | 10mg | $70 | 2026-05-28 | Buy |
| aablocks | AA001TBA | LDN-214117 | 25mg | $166 | 2026-05-28 | Buy |
| aablocks | AA001TBA | LDN-214117 | 50mg | $270 | 2026-05-28 | Buy |
| aablocks | AA001TBA | LDN-214117 | 100mg | $406 | 2026-05-28 | Buy |
| aablocks | AA001TBA | LDN-214117 98% | 5mg | $38 | 2026-05-28 | Buy |
| aablocks | AA001TBA | LDN-214117 ≥98% | 1mg | $36 | 2026-05-28 | Buy |
| Ambeed | A637146 | LDN-214117 98+% | 100mg | $495 | 2021-12-16 | Buy |
| Ambeed | A637146 | LDN-214117 98+% | 50mg | $315 | 2021-12-16 | Buy |
| Ambeed | A637146 | LDN-214117 98+% | 10mg | $90 | 2021-12-16 | Buy |
| Ambeed | A637146 | LDN-214117 98+% | 1mg | $30 | 2021-12-16 | Buy |
| Ambeed | A637146 | LDN-214117 98+% | 5mg | $50 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0002514 | 1-(4-(6-METHYL-5-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-3-YL)PHENYL)PIPERAZINE 95.00% | 5MG | $496.93 | 2021-12-16 | Buy |
| ApexBio Technology | B4842 | LDN-214117 | 100mg | $595 | 2026-05-06 | Buy |
| ApexBio Technology | B4842 | LDN-214117 | 5mg | $70 | 2026-05-06 | Buy |
| ApexBio Technology | B4842 | LDN-214117 | 25mg | $245 | 2026-05-06 | Buy |
| Arctom | SLK-S7627 | LDN-214117 99.97% | 25mg | $330 | 2026-05-26 | Buy |
Properties
Boiling point :567.9±50.0 °C(Predicted)
Density :1.134±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF:30.0(Max Conc. mg/mL);71.51(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.19(Max Conc. mM)
DMSO:42.67(Max Conc. mg/mL);101.7(Max Conc. mM)
Ethanol:54.0(Max Conc. mg/mL);128.72(Max Conc. mM) pka :8.86±0.10(Predicted)
form :Powder
color :Light yellow to yellow
InChI :1S/C25H29N3O3/c1-17-22(19-14-23(29-2)25(31-4)24(15-19)30-3)13-20(16-27-17)18-5-7-21(8-6-18)28-11-9-26-10-12-28/h5-8,13-16,26H,9-12H2,1-4H3
InChIKey :BHUXVRVMMYAXKN-UHFFFAOYSA-N
SMILES :CC(C(C1=CC(OC)=C(OC)C(OC)=C1)=C2)=NC=C2C(C=C3)=CC=C3N4CCNCC4
Density :1.134±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF:30.0(Max Conc. mg/mL);71.51(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.19(Max Conc. mM)
DMSO:42.67(Max Conc. mg/mL);101.7(Max Conc. mM)
Ethanol:54.0(Max Conc. mg/mL);128.72(Max Conc. mM) pka :8.86±0.10(Predicted)
form :Powder
color :Light yellow to yellow
InChI :1S/C25H29N3O3/c1-17-22(19-14-23(29-2)25(31-4)24(15-19)30-3)13-20(16-27-17)18-5-7-21(8-6-18)28-11-9-26-10-12-28/h5-8,13-16,26H,9-12H2,1-4H3
InChIKey :BHUXVRVMMYAXKN-UHFFFAOYSA-N
SMILES :CC(C(C1=CC(OC)=C(OC)C(OC)=C1)=C2)=NC=C2C(C=C3)=CC=C3N4CCNCC4
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Bone morphogenetic proteins (BMPs) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation. Activation of BMP type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. LDN-214117 is a selective BMP type I receptor kinase ALK1 and ALK2 inhibitor (IC50s = 24 nM for each). It demonstrates preference for ALK1 and ALK2 over ALK3 (IC50 = 1.17 μM) and other related activin and TGF-β type I receptors (IC50s = 3, 0.1, and 16 μM for ALK5, BMP6, and TGF-β, respectively).More related product prices
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Suppliers and manufacturers
Dideu Industries Group Limited
Aladdin Scientific
Chembest Research Laboratories Limited
BOC Sciences
ShangHai Caerulum Pharma Discovery Co., Ltd.
Bide Pharmatech Ltd.
Shanghai Lollane Biological Technology Co.,Ltd.
YouCoChem (Beijing) Chemical Technology Co., Ltd.
Shanghai EFE Biological Technology Co., Ltd.
