ML-323
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- $60 - $2841
- Product name: ML-323
- CAS: 1572414-83-5
- MF: C23H24N6
- MW: 384.48
- EINECS:
- MDL Number:MFCD28099817
- Synonyms:ML-323;5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine;4-Pyrimidinamine, 5-methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-;5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine ML323;ML323, >=98%;N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine;ML323, 99%, an USP1-UAF1 inhibitor;5-Methyl-2-(2-propan-2-ylphenyl)-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine
61 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Synthonix
- Tocris
- TRC
Package
- 10mg
- 10mM*1mLinDMSO
- 5MG
- 25mg
- 50mg
- 100mg
- 250mg
- 25
- 5
- 10mM(in1mLDMSO)
- 500mg
- 1g
- 1000mg
- 5 mg
- 10 mg
- 10mM(1mLinDMSO)
- 25 mg
- ManufacturerAK Scientific
- Product number2555AH
- Product description5-Methyl-2-(2-propan-2-ylphenyl)-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine
- Packaging25mg
- Price$259
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004713
- Product descriptionML-323 95.00%
- Packaging5MG
- Price$495.44
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1317
- Product descriptionML-323
- Packaging25mg
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1317
- Product descriptionML-323
- Packaging25mg
- Price$308
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1317
- Product descriptionML-323
- Packaging5mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1317
- Product descriptionML-323
- Packaging5mg
- Price$72
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1317
- Product descriptionML-323
- Packaging10mM(in1mLDMSO)
- Price$77
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberSLK-S7529
- Product descriptionML323 99.99%
- Packaging5mg
- Price$140
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S7529
- Product descriptionML323 99.99%
- Packaging10mM(1mLinDMSO)
- Price$188
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S7529
- Product descriptionML323 99.99%
- Packaging25mg
- Price$559
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S7529
- Product descriptionML323 99.99%
- Packaging100mg
- Price$1577
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S7529
- Product descriptionML323 99.99%
- Packaging1g
- Price$2841
- Updated2026-05-26
- Buy
- ManufacturerAvaChem
- Product number6546
- Product descriptionML-323 98%
- Packaging5mg
- Price$80
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number6546
- Product descriptionML-323 98%
- Packaging25mg
- Price$320
- Updated2026-05-22
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2309
- Product descriptionML323 100%
- Packaging25mg
- Price$335.5
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2309
- Product descriptionML 323
- Packaging25mg
- Price$335.5
- Updated2026-05-19
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2555AH | 5-Methyl-2-(2-propan-2-ylphenyl)-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine | 25mg | $259 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004713 | ML-323 95.00% | 5MG | $495.44 | 2021-12-16 | Buy |
| ApexBio Technology | B1317 | ML-323 | 25mg | $280 | 2021-12-16 | Buy |
| ApexBio Technology | B1317 | ML-323 | 25mg | $308 | 2026-05-06 | Buy |
| ApexBio Technology | B1317 | ML-323 | 5mg | $65 | 2021-12-16 | Buy |
| ApexBio Technology | B1317 | ML-323 | 5mg | $72 | 2026-05-06 | Buy |
| ApexBio Technology | B1317 | ML-323 | 10mM(in1mLDMSO) | $77 | 2026-05-06 | Buy |
| Arctom | SLK-S7529 | ML323 99.99% | 5mg | $140 | 2026-05-26 | Buy |
| Arctom | SLK-S7529 | ML323 99.99% | 10mM(1mLinDMSO) | $188 | 2026-05-26 | Buy |
| Arctom | SLK-S7529 | ML323 99.99% | 25mg | $559 | 2026-05-26 | Buy |
| Arctom | SLK-S7529 | ML323 99.99% | 100mg | $1577 | 2026-05-26 | Buy |
| Arctom | SLK-S7529 | ML323 99.99% | 1g | $2841 | 2026-05-26 | Buy |
| AvaChem | 6546 | ML-323 98% | 5mg | $80 | 2026-05-22 | Buy |
| AvaChem | 6546 | ML-323 98% | 25mg | $320 | 2026-05-22 | Buy |
| Axon Medchem | Axon2309 | ML323 100% | 25mg | $335.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon2309 | ML 323 | 25mg | $335.5 | 2026-05-19 | Buy |
Properties
Boiling point :515.4±60.0 °C(Predicted)
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 40 mg/ml), or in Ethanol (up to 20 mg/ml)
pka :5.37±0.10(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :1S/C23H24N6/c1-16(2)20-6-4-5-7-21(20)23-24-14-17(3)22(27-23)25-15-18-8-10-19(11-9-18)29-13-12-26-28-29/h4-14,16H,15H2,1-3H3,(H,24,25,27)
InChIKey :VUIRVWPJNKZOSS-UHFFFAOYSA-N
SMILES :[n]4(nncc4)c1ccc(cc1)CNc2nc(ncc2C)c3c(cccc3)C(C)C
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 40 mg/ml), or in Ethanol (up to 20 mg/ml)
pka :5.37±0.10(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :1S/C23H24N6/c1-16(2)20-6-4-5-7-21(20)23-24-14-17(3)22(27-23)25-15-18-8-10-19(11-9-18)29-13-12-26-28-29/h4-14,16H,15H2,1-3H3,(H,24,25,27)
InChIKey :VUIRVWPJNKZOSS-UHFFFAOYSA-N
SMILES :[n]4(nncc4)c1ccc(cc1)CNc2nc(ncc2C)c3c(cccc3)C(C)C
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
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Description
The USP1 deubiquitinating enzyme, which regulates the DNA translesion synthesis (TLS) and Fanconi anemia (FA) DNA damage response pathways by deubiquitinating the central players of these pathways, is activated by the WD40-repeat containing UAF1 protein through formation of a stable USP1-UAF1 protein complex. ML-323 is an inhibitor of the USP1-UAF1 deubiquitinase complex with an IC50 value of 76 nM. It demonstrates excellent selectivity against other human deubiquitinases, deSUMOylase, deneddylase, and unrelated proteases. ML-323 has been shown to inhibit the deubiquitination of proliferating cell nuclear antigen and FA complementation group D2 by inhibiting USP1-UAF1 activity in H596 cells. ML-323 potentiates cisplatin cytotoxicity in NSCLC H596 cells and U2OS osteosarcoma cells by targeting the TLS and FA DNA damage response pathways.More related product prices
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