MPI-0479605
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- $25 - $2095
- Product name: MPI-0479605
- CAS: 1246529-32-7
- MF: C22H29N7O
- MW: 407.51
- EINECS:
- MDL Number:MFCD28099811
- Synonyms:MPI-0479605;N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine;MPI0479605 HCl;N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine;MPI-0479605;MPI 0479605;MPI0479605;9H-?Purine-?2,?6-?diamine, N6-?cyclohexyl-?N2-?[2-?methyl-?4-?(4-?morpholinyl)?phenyl]?-;CS-1459;MPI-0479605 USP/EP/BP
60 prices
Selected condition:
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
Package
- 2mg
- 10mM*1mLinDMSO(Solution)
- 1mg
- 10mM*1mLinDMSO
- 5mg
- 10mg
- 50mg
- 10mM(1mLinDMSO)
- 25mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA009CGG
- Product descriptionN6-Cyclohexyl-N2-(2-Methyl-4-Morpholinophenyl)-9H-Purine-2,6-Diamine 98%
- Packaging100mg
- Price$190
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CGG
- Product descriptionN6-Cyclohexyl-N2-(2-Methyl-4-Morpholinophenyl)-9H-Purine-2,6-Diamine 98%
- Packaging250mg
- Price$318
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CGG
- Product descriptionN6-Cyclohexyl-N2-(2-Methyl-4-Morpholinophenyl)-9H-Purine-2,6-Diamine 98%
- Packaging1g
- Price$840
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CGG
- Product descriptionN6-Cyclohexyl-N2-(2-Methyl-4-Morpholinophenyl)-9H-Purine-2,6-Diamine ≥98%
- Packaging50mg
- Price$98
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CGG
- Product descriptionN6-Cyclohexyl-N2-(2-Methyl-4-Morpholinophenyl)-9H-Purine-2,6-Diamine ≥98%
- Packaging25mg
- Price$55
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CGG
- Product descriptionN6-Cyclohexyl-N2-(2-Methyl-4-Morpholinophenyl)-9H-Purine-2,6-Diamine ≥98%
- Packaging10mg
- Price$25
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY227382
- Product descriptionMPI-0479605 97.00%
- Packaging100MG
- Price$545
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY227382
- Product descriptionMPI-0479605 97.00%
- Packaging25MG
- Price$190
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1187-M001
- Product descriptionMPI-0479605hydrochloride ≥95%
- Packaging1mg
- Price$205
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1187-M001
- Product descriptionMPI-0479605 hydrochloride ≥95%
- Packaging1mg
- Price$205
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1187-M005
- Product descriptionMPI-0479605hydrochloride ≥95%
- Packaging5mg
- Price$346
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1187-M005
- Product descriptionMPI-0479605 hydrochloride ≥95%
- Packaging5mg
- Price$346
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1187-M010
- Product descriptionMPI-0479605 hydrochloride ≥95%
- Packaging10mg
- Price$535
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number2574AH
- Product descriptionN6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine
- Packaging1g
- Price$1246
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3706
- Product descriptionMPI-0479605
- Packaging50mg
- Price$1276
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB3706
- Product descriptionMPI-0479605
- Packaging10mg
- Price$612
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009CGG | N6-Cyclohexyl-N2-(2-Methyl-4-Morpholinophenyl)-9H-Purine-2,6-Diamine 98% | 100mg | $190 | 2026-05-28 | Buy |
| aablocks | AA009CGG | N6-Cyclohexyl-N2-(2-Methyl-4-Morpholinophenyl)-9H-Purine-2,6-Diamine 98% | 250mg | $318 | 2026-05-28 | Buy |
| aablocks | AA009CGG | N6-Cyclohexyl-N2-(2-Methyl-4-Morpholinophenyl)-9H-Purine-2,6-Diamine 98% | 1g | $840 | 2026-05-28 | Buy |
| aablocks | AA009CGG | N6-Cyclohexyl-N2-(2-Methyl-4-Morpholinophenyl)-9H-Purine-2,6-Diamine ≥98% | 50mg | $98 | 2026-05-28 | Buy |
| aablocks | AA009CGG | N6-Cyclohexyl-N2-(2-Methyl-4-Morpholinophenyl)-9H-Purine-2,6-Diamine ≥98% | 25mg | $55 | 2026-05-28 | Buy |
| aablocks | AA009CGG | N6-Cyclohexyl-N2-(2-Methyl-4-Morpholinophenyl)-9H-Purine-2,6-Diamine ≥98% | 10mg | $25 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y227382 | MPI-0479605 97.00% | 100MG | $545 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y227382 | MPI-0479605 97.00% | 25MG | $190 | 2026-05-27 | Buy |
| Adipogen Life Sciences | SYN-1187-M001 | MPI-0479605hydrochloride ≥95% | 1mg | $205 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1187-M001 | MPI-0479605 hydrochloride ≥95% | 1mg | $205 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1187-M005 | MPI-0479605hydrochloride ≥95% | 5mg | $346 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1187-M005 | MPI-0479605 hydrochloride ≥95% | 5mg | $346 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1187-M010 | MPI-0479605 hydrochloride ≥95% | 10mg | $535 | 2026-05-06 | Buy |
| AK Scientific | 2574AH | N6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine | 1g | $1246 | 2021-12-16 | Buy |
| ApexBio Technology | B3706 | MPI-0479605 | 50mg | $1276 | 2026-05-06 | Buy |
| ApexBio Technology | B3706 | MPI-0479605 | 10mg | $612 | 2021-12-16 | Buy |
Properties
Boiling point :745.8±70.0 °C(Predicted)
Density :1.318±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in DMSO
form :A crystalline solid
pka :10.52±0.10(Predicted)
color :White to gray
Density :1.318±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in DMSO
form :A crystalline solid
pka :10.52±0.10(Predicted)
color :White to gray
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||
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Description
MPI-0479605 is a potent and ATP-competitive inhibitor of the mitotic kinase MPS1 (IC50 = 1.8 nM). It is selective for MPS1 over a panel of 79 kinases at a concentration of 500 nM. MPI-0479605 induces time-dependent degradation of cyclin B and securin and decreases phosphorylation of BUBR1 resulting in failed cytokinesis in HeLa cells arrested by nocodazole . It also causes misalignment of chromosomes at the anaphase plate and aneuploidy in A549 cells and slows cell cycle progression of HCT116 and COLO 205 cells irrespective of p53 activity. MPI-0479605 (30-150 mg/kg) reduces tumor volume in an HCT116 mouse colon cancer xenograft model in a dose-dependent manner.Related product price
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