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ChemicalBook >> CAS DataBase List >> MRTX1133

MRTX1133

$23 - $3350
Product name: MRTX1133
CAS: 2621928-55-8
MF: C33H31F3N6O2
MW: 600.63
EINECS:
MDL Number:MFCD34567005
Synonyms:2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-;4-(4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol;MRTX1133;4-[4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2S,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol;KRAS,Ras,MRTX 1133,G12D,cells,active,wild-type,phosphorylation,mutant,MRTX1133,inactive,ERK,inhibit,tumor,states,MRTX-1133,Inhibitor;4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-Naphthalenol;4-[4-[3,8-Diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2S,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol;Niraparib (MK-4827) tosylate monohydrate

Price25 Properties Safety Information Description

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Brand

aablocks
ACHEMBLOCK
ApexBio Technology
Axon Medchem
Cayman Chemical
ChemScene
DC Chemicals

Package

1mg
5mg
10mg
25mg
50mg
100mg
250mg
1G
5G

Manufactureraablocks
Product numberAA01X1DK
Product description4-[4-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-naphthalenol 98%LC
Packaging25mg
Price$66
Updated2026-06-01
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Manufactureraablocks
Product numberAA01X1DK
Product description4-[4-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-naphthalenol 98%LC
Packaging5mg
Price$23
Updated2026-06-01
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Manufactureraablocks
Product numberAA01X1DK
Product description4-[4-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-naphthalenol 98%LC
Packaging10mg
Price$35
Updated2026-06-01
Buy

Manufactureraablocks
Product numberAA01X1DK
Product description4-[4-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-naphthalenol 98%LC
Packaging50mg
Price$111
Updated2026-06-01
Buy

Manufactureraablocks
Product numberAA01X1DK
Product description4-[4-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-naphthalenol 98%LC
Packaging100mg
Price$189
Updated2026-06-01
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ManufacturerACHEMBLOCK
Product numberU142723
Product descriptionMRTX1133 98%
Packaging100MG
Price$220
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberU142723
Product descriptionMRTX1133 98%
Packaging25MG
Price$80
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberU142723
Product descriptionMRTX1133 98%
Packaging1G
Price$1050
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberU142723
Product descriptionMRTX1133 98%
Packaging5G
Price$3350
Updated2026-05-27
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ManufacturerApexBio Technology
Product numberB8761
Product descriptionMRTX-1133
Packaging1mg
Price$84
Updated2026-05-06
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ManufacturerApexBio Technology
Product numberB8761
Product descriptionMRTX-1133
Packaging5mg
Price$305
Updated2026-05-06
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ManufacturerApexBio Technology
Product numberB8761
Product descriptionMRTX-1133
Packaging10mg
Price$446
Updated2026-05-06
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ManufacturerAxon Medchem
Product numberAxon3761
Product descriptionMRTX1133 99%
Packaging5mg
Price$242
Updated2026-05-19
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ManufacturerAxon Medchem
Product numberAxon3761
Product descriptionMRTX1133 99%
Packaging25mg
Price$836
Updated2026-05-19
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ManufacturerCayman Chemical
Product number36413
Product descriptionMRTX-1133 ≥98%
Packaging5mg
Price$108
Updated2026-04-30
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ManufacturerCayman Chemical
Product number36413
Product descriptionMRTX-1133 ≥98%
Packaging10mg
Price$162
Updated2026-04-30
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA01X1DK	4-[4-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-naphthalenol 98%LC	25mg	$66	2026-06-01	Buy
aablocks	AA01X1DK	4-[4-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-naphthalenol 98%LC	5mg	$23	2026-06-01	Buy
aablocks	AA01X1DK	4-[4-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-naphthalenol 98%LC	10mg	$35	2026-06-01	Buy
aablocks	AA01X1DK	4-[4-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-naphthalenol 98%LC	50mg	$111	2026-06-01	Buy
aablocks	AA01X1DK	4-[4-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-naphthalenol 98%LC	100mg	$189	2026-06-01	Buy
ACHEMBLOCK	U142723	MRTX1133 98%	100MG	$220	2026-05-27	Buy
ACHEMBLOCK	U142723	MRTX1133 98%	25MG	$80	2026-05-27	Buy
ACHEMBLOCK	U142723	MRTX1133 98%	1G	$1050	2026-05-27	Buy
ACHEMBLOCK	U142723	MRTX1133 98%	5G	$3350	2026-05-27	Buy
ApexBio Technology	B8761	MRTX-1133	1mg	$84	2026-05-06	Buy
ApexBio Technology	B8761	MRTX-1133	5mg	$305	2026-05-06	Buy
ApexBio Technology	B8761	MRTX-1133	10mg	$446	2026-05-06	Buy
Axon Medchem	Axon3761	MRTX1133 99%	5mg	$242	2026-05-19	Buy
Axon Medchem	Axon3761	MRTX1133 99%	25mg	$836	2026-05-19	Buy
Cayman Chemical	36413	MRTX-1133 ≥98%	5mg	$108	2026-04-30	Buy
Cayman Chemical	36413	MRTX-1133 ≥98%	10mg	$162	2026-04-30	Buy

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Properties

Density :1.49±0.1 g/cm3(Predicted)
solubility :DMSO:50.0(Max Conc. mg/mL);83.24(Max Conc. mM)
form :A solid
pka :8.05±0.40(Predicted)
color :Yellow to brown
InChIKey :SCLLZBIBSFTLIN-IFMUVJFISA-N
SMILES :C1=C2C(C(C#C)=C(F)C=C2)=C(C2N=CC3=C(N4CC5NC(CC5)C4)N=C(OC[C@]45C[C@@H](F)CN4CCC5)N=C3C=2F)C=C1O

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning		P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning		P264, P280, P305+P351+P338,P337+P313P

Precautionary statements:

P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321	Specific treatment (see … on this label).
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.

Description

MRTX1133 is an exceptionally potent and selective KRASG12D inhibitor with high affinity.

Suppliers and manufacturers

Nantong Hi-Future Biotechnology Co., Ltd ShangHai Biochempartner Co.,Ltd Changzhou Chenhong Biotechnology Co., Ltd. Changzhou Borl Biotechnology Co.,LTD Wuxi Donghe Pharmaceutical Technology Co., Ltd. ShangHai ChuanQian Chemcial Technique Centre Energy Chemical Beijing Ouhe Technology Co., Ltd ShangHai Caerulum Pharma Discovery Co., Ltd. Suzhou Sino Rare Chemical Co., Ltd.

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