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ChemicalBook >> CAS DataBase List >> Mubritinib

Mubritinib

Mubritinib price.
  • $24 - $2023
  • Product name: Mubritinib
  • CAS: 366017-09-6
  • MF: C25H23F3N4O2
  • MW: 468.47
  • EINECS:
  • MDL Number:MFCD09954135
  • Synonyms:MUBRITINIB;1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole;TAK 165;Mubritinib(TAK 165);(E)-1-(4-(4-((2-(4-(trifluoromethyl)styryl)oxazol-4-yl)methoxy)phenyl)butyl)-1H-1,2,3-triazole;1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole Mubritinib (TAK 165);Mubritinib 1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole;(E)-4-((4-(4-(1H-1,2,3-Triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole
Price62 Properties Safety Information Description
62 prices
Selected condition：
Brand
  • aablocks
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 10mM(1mLinDMSO)
  • 1MG
  • 5mg
  • 10mM*1mLinDMSO
  • 1unit
  • 10
  • 50
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 1g
  • 1000mg
  • Manufactureraablocks
  • Product numberAA0078QG
  • Product description1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole 98%
  • Packaging5mg
  • Price$24
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0078QG
  • Product description1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole 98%
  • Packaging10mg
  • Price$38
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0078QG
  • Product description1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole 98
  • Packaging50mg
  • Price$167
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0078QG
  • Product description1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole 98
  • Packaging100mg
  • Price$299
  • Updated2026-05-28
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3755-M005
  • Product descriptionMubritinib ≥95%
  • Packaging5mg
  • Price$30
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3755-M025
  • Product descriptionMubritinib ≥95%
  • Packaging25mg
  • Price$120
  • Updated2026-05-06
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1112
  • Product descriptionMubritinib
  • Packaging5mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1112
  • Product descriptionMubritinib
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000892
  • Product descriptionMUBRITINIB 95.00%
  • Packaging1MG
  • Price$166.95
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000892
  • Product descriptionMUBRITINIB 95.00%
  • Packaging10MG
  • Price$726.44
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000892
  • Product descriptionMUBRITINIB 95.00%
  • Packaging50MG
  • Price$1352.22
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1543
  • Product descriptionMubritinib(TAK165)
  • Packaging200mg
  • Price$610
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1543
  • Product descriptionMubritinib (TAK 165)
  • Packaging100mg
  • Price$412
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1543
  • Product descriptionMubritinib (TAK 165)
  • Packaging50mg
  • Price$219
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1543
  • Product descriptionMubritinib (TAK 165)
  • Packaging25mg
  • Price$145
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1543
  • Product descriptionMubritinib(TAK165)
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA0078QG 1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole 98% 5mg $24 2026-05-28 Buy
aablocks AA0078QG 1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole 98% 10mg $38 2026-05-28 Buy
aablocks AA0078QG 1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole 98 50mg $167 2026-05-28 Buy
aablocks AA0078QG 1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole 98 100mg $299 2026-05-28 Buy
Adipogen Life Sciences AG-CR1-3755-M005 Mubritinib ≥95% 5mg $30 2026-05-06 Buy
Adipogen Life Sciences AG-CR1-3755-M025 Mubritinib ≥95% 25mg $120 2026-05-06 Buy
AK Scientific SYN1112 Mubritinib 5mg $85 2021-12-16 Buy
AK Scientific SYN1112 Mubritinib 10mg $90 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000892 MUBRITINIB 95.00% 1MG $166.95 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000892 MUBRITINIB 95.00% 10MG $726.44 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000892 MUBRITINIB 95.00% 50MG $1352.22 2021-12-16 Buy
ApexBio Technology B1543 Mubritinib(TAK165) 200mg $610 2021-12-16 Buy
ApexBio Technology B1543 Mubritinib (TAK 165) 100mg $412 2026-05-06 Buy
ApexBio Technology B1543 Mubritinib (TAK 165) 50mg $219 2026-05-06 Buy
ApexBio Technology B1543 Mubritinib (TAK 165) 25mg $145 2026-05-06 Buy
ApexBio Technology B1543 Mubritinib(TAK165) 1unit $28 2021-12-16 Buy
Next Last

Properties

Melting point :158.0 to 162.0 °C
Boiling point :620.9±65.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :DMSO : 50 mg/mL (106.73 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
pka :1.45±0.10(Predicted)
form :powder to crystal
color :White to Gray to Brown
InChI :InChI=1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+
InChIKey :ZTFBIUXIQYRUNT-MDWZMJQESA-N
SMILES :N1(CCCCC2=CC=C(OCC3=COC(/C=C/C4=CC=C(C(F)(F)F)C=C4)=N3)C=C2)C=CN=N1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Mubritinib is a selective inhibitor of the human epidermal growth factor receptor 2 (HER2), inhibiting HER2 phosphorylation with an IC50 value of 6 nM. It is without effect on EGFR, FGFR, PDGFR, JAK1, Src, and Blk (IC50 > 25 μM). Mubritinib inhibits the proliferation of breast, bladder, kidney, and prostate cancer cells in vitro and in vivo.

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Suppliers and manufacturers

Guangzhou Tomums Life Science Co., Ltd. Shanghai Boyle Chemical Co., Ltd. 3B Pharmachem (Wuhan) International Co.,Ltd. Chembest Research Laboratories Limited TCI (Shanghai) Development Co., Ltd. LGM Pharma Shanghai Longsheng chemical Co.,Ltd. China DongFan Chemical Co.,LTD Jinan Trio PharmaTech Co., Ltd. Dalian Meilun Biotech Co., Ltd.