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ChemicalBook >> CAS DataBase List >> NDI-010976

NDI-010976

NDI-010976 price.
  • $270 - $2301.75
  • Product name: NDI-010976
  • CAS: 1434635-54-7
  • MF: C28H31N3O8S
  • MW: 569.63
  • EINECS:-0
  • MDL Number:MFCD28963986
  • Synonyms:NDI-010976;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoicacid;ND-630;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid;EOS-61252;GS0976;CPDB5078;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-
Price13 Properties Safety Information Description
13 prices
Selected condition：
Brand
  • AK Scientific
  • Alichem
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number9222DU
  • Product descriptionFirsocostat
  • Packaging5mg
  • Price$1412
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number1434635547
  • Product description(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2h-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2h)-yl)-2-methylpropanoicacid
  • Packaging250mg
  • Price$995.1
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number1434635547
  • Product description(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2h-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2h)-yl)-2-methylpropanoicacid
  • Packaging1g
  • Price$2301.75
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0005695
  • Product description(R)-2-(1-(2-(2-METHOXYPHENYL)-2-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)ETHYL)-5-METHYL-6-(OXAZOL-2-YL)-2,4-DIOXO-1,2-DIHYDROTHIENO[2,3-D]PYRIMIDIN-3(4H)-YL)-2-METHYLPROPANOIC ACID 95.00%
  • Packaging5MG
  • Price$497.67
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number23961
  • Product descriptionND-630 ≥98%
  • Packaging1mg
  • Price$364
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23961
  • Product descriptionND-630 ≥98%
  • Packaging5mg
  • Price$1181
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6509
  • Product descriptionFirsocostat 99.48%
  • Packaging5mg
  • Price$270
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6509
  • Product descriptionFirsocostat 99.48%
  • Packaging10mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6509
  • Product descriptionFirsocostat 99.48%
  • Packaging25mg
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6509
  • Product descriptionFirsocostat 99.48%
  • Packaging50mg
  • Price$850
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6509
  • Product descriptionFirsocostat 99.48%
  • Packaging100mg
  • Price$1150
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10173
  • Product descriptionFirsocostat(ND-630,GS-0976) >98%
  • Packaging100mg
  • Price$750
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10173
  • Product descriptionFirsocostat(ND-630,GS-0976) >98%
  • Packaging250mg
  • Price$1300
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9222DU Firsocostat 5mg $1412 2021-12-16 Buy
Alichem 1434635547 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2h-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2h)-yl)-2-methylpropanoicacid 250mg $995.1 2021-12-16 Buy
Alichem 1434635547 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2h-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2h)-yl)-2-methylpropanoicacid 1g $2301.75 2021-12-16 Buy
American Custom Chemicals Corporation INB0005695 (R)-2-(1-(2-(2-METHOXYPHENYL)-2-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)ETHYL)-5-METHYL-6-(OXAZOL-2-YL)-2,4-DIOXO-1,2-DIHYDROTHIENO[2,3-D]PYRIMIDIN-3(4H)-YL)-2-METHYLPROPANOIC ACID 95.00% 5MG $497.67 2021-12-16 Buy
Cayman Chemical 23961 ND-630 ≥98% 1mg $364 2024-03-01 Buy
Cayman Chemical 23961 ND-630 ≥98% 5mg $1181 2024-03-01 Buy
ChemScene CS-6509 Firsocostat 99.48% 5mg $270 2021-12-16 Buy
ChemScene CS-6509 Firsocostat 99.48% 10mg $450 2021-12-16 Buy
ChemScene CS-6509 Firsocostat 99.48% 25mg $650 2021-12-16 Buy
ChemScene CS-6509 Firsocostat 99.48% 50mg $850 2021-12-16 Buy
ChemScene CS-6509 Firsocostat 99.48% 100mg $1150 2021-12-16 Buy
DC Chemicals DC10173 Firsocostat(ND-630,GS-0976) >98% 100mg $750 2021-12-16 Buy
DC Chemicals DC10173 Firsocostat(ND-630,GS-0976) >98% 250mg $1300 2021-12-16 Buy

Properties

Boiling point :779.0±70.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:75.0(Max Conc. mg/mL);131.66(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);17.56(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);5.27(Max Conc. mM) form :A crystalline solid
pka :3.66±0.10(Predicted)
color :White to light yellow
InChIKey :ZZWWXIBKLBMSCS-XKGZFIRZNA-N
SMILES :C(O)(=O)C(N1C(=O)N(C[C@@H](C2=CC=CC=C2OC)OC2CCOCC2)C2SC(C3=NC=CO3)=C(C)C=2C1=O)(C)C |&1:9,r|

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 μM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC50s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.

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Suppliers and manufacturers

career henan chemical co
NDI-010976
$7.00 /1KG
NDI-010976 CAS:1434635-54-7
TargetMol Chemicals Inc.
Firsocostat
$88.00 /1mg
Firsocostat CAS:1434635-54-7
ATK CHEMICAL COMPANY LIMITED
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