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ChemicalBook >> CAS DataBase List >> NDI-010976

NDI-010976

NDI-010976 price.
  • $29 - $5691
  • Product name: NDI-010976
  • CAS: 1434635-54-7
  • MF: C28H31N3O8S
  • MW: 569.63
  • EINECS:-0
  • MDL Number:MFCD28963986
  • Synonyms:NDI-010976;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoicacid;ND-630;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid;EOS-61252;GS0976;CPDB5078;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-
Price46 Properties Safety Information Description
46 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Alichem
  • American Custom Chemicals Corporation
  • Arctom
  • AvaChem
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
Package
  • 10mM(1mLinDMSO)
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 10mM*1mLinDMSO
  • 50mg
  • 100mg
  • 10mM*1mLinDMSO(Solution)
  • 250mg
  • 1G
  • 10mM*1mLinDMSO(Solid+Solvent)
  • Manufactureraablocks
  • Product numberAA01EN26
  • Product description1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid ≥98%
  • Packaging2mg
  • Price$29
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN26
  • Product description1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid 97%
  • Packaging5mg
  • Price$48
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN26
  • Product description1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid 97%
  • Packaging25mg
  • Price$120
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN26
  • Product description1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid 97%
  • Packaging10mg
  • Price$72
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN26
  • Product description1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid 97%
  • Packaging50mg
  • Price$183
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN26
  • Product description1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid 95%
  • Packaging100mg
  • Price$300
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN26
  • Product description1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid 95%
  • Packaging250mg
  • Price$484
  • Updated2026-05-30
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberQ65419
  • Product description(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoic acid 98%
  • Packaging100MG
  • Price$260
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberQ65419
  • Product description(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoic acid 98%
  • Packaging25MG
  • Price$104
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberQ65419
  • Product description(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoic acid 98%
  • Packaging5MG
  • Price$40
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberQ65419
  • Product description(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoic acid 98%
  • Packaging1G
  • Price$1180
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number9222DU
  • Product descriptionFirsocostat
  • Packaging5mg
  • Price$1412
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number1434635547
  • Product description(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2h-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2h)-yl)-2-methylpropanoicacid
  • Packaging1g
  • Price$2301.75
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number1434635547
  • Product description(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2h-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2h)-yl)-2-methylpropanoicacid
  • Packaging250mg
  • Price$995.1
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0005695
  • Product description(R)-2-(1-(2-(2-METHOXYPHENYL)-2-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)ETHYL)-5-METHYL-6-(OXAZOL-2-YL)-2,4-DIOXO-1,2-DIHYDROTHIENO[2,3-D]PYRIMIDIN-3(4H)-YL)-2-METHYLPROPANOIC ACID 95.00%
  • Packaging5MG
  • Price$497.67
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberHY-16901
  • Product descriptionFirsocostat 99.96%
  • Packaging25mg
  • Price$618
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA01EN26 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid ≥98% 2mg $29 2026-05-30 Buy
aablocks AA01EN26 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid 97% 5mg $48 2026-05-30 Buy
aablocks AA01EN26 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid 97% 25mg $120 2026-05-30 Buy
aablocks AA01EN26 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid 97% 10mg $72 2026-05-30 Buy
aablocks AA01EN26 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid 97% 50mg $183 2026-05-30 Buy
aablocks AA01EN26 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid 95% 100mg $300 2026-05-30 Buy
aablocks AA01EN26 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid 95% 250mg $484 2026-05-30 Buy
ACHEMBLOCK Q65419 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoic acid 98% 100MG $260 2026-05-27 Buy
ACHEMBLOCK Q65419 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoic acid 98% 25MG $104 2026-05-27 Buy
ACHEMBLOCK Q65419 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoic acid 98% 5MG $40 2026-05-27 Buy
ACHEMBLOCK Q65419 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoic acid 98% 1G $1180 2026-05-27 Buy
AK Scientific 9222DU Firsocostat 5mg $1412 2021-12-16 Buy
Alichem 1434635547 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2h-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2h)-yl)-2-methylpropanoicacid 1g $2301.75 2021-12-16 Buy
Alichem 1434635547 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2h-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2h)-yl)-2-methylpropanoicacid 250mg $995.1 2021-12-16 Buy
American Custom Chemicals Corporation INB0005695 (R)-2-(1-(2-(2-METHOXYPHENYL)-2-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)ETHYL)-5-METHYL-6-(OXAZOL-2-YL)-2,4-DIOXO-1,2-DIHYDROTHIENO[2,3-D]PYRIMIDIN-3(4H)-YL)-2-METHYLPROPANOIC ACID 95.00% 5MG $497.67 2021-12-16 Buy
Arctom HY-16901 Firsocostat 99.96% 25mg $618 2026-05-26 Buy
Next Last

Properties

Boiling point :779.0±70.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:75.0(Max Conc. mg/mL);131.66(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);17.56(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);5.27(Max Conc. mM) form :A crystalline solid
pka :3.66±0.10(Predicted)
color :White to light yellow
InChIKey :ZZWWXIBKLBMSCS-XKGZFIRZNA-N
SMILES :C(O)(=O)C(N1C(=O)N(C[C@@H](C2=CC=CC=C2OC)OC2CCOCC2)C2SC(C3=NC=CO3)=C(C)C=2C1=O)(C)C |&1:9,r|

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 μM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC50s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.

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Suppliers and manufacturers

ShangHai Caerulum Pharma Discovery Co., Ltd. Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd Shanghai Boyle Chemical Co., Ltd. Chembest Research Laboratories Limited Nanjing Chemlin Chemical Co., Ltd Shanghai Topbiochem Technology Co., Ltd Syncozymes (Shanghai) Co.,Ltd. MedChemexpress LLC Bide Pharmatech Ltd. Shanghai Lollane Biological Technology Co.,Ltd.