NDI-010976
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- $270 - $2301.75
- Product name: NDI-010976
- CAS: 1434635-54-7
- MF: C28H31N3O8S
- MW: 569.63
- EINECS:-0
- MDL Number:MFCD28963986
- Synonyms:NDI-010976;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoicacid;ND-630;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid;EOS-61252;GS0976;CPDB5078;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-
13 prices
Selected condition：
Brand
- AK Scientific
- Alichem
- American Custom Chemicals Corporation
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number9222DU
- Product descriptionFirsocostat
- Packaging5mg
- Price$1412
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number1434635547
- Product description(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2h-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2h)-yl)-2-methylpropanoicacid
- Packaging250mg
- Price$995.1
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number1434635547
- Product description(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2h-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2h)-yl)-2-methylpropanoicacid
- Packaging1g
- Price$2301.75
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005695
- Product description(R)-2-(1-(2-(2-METHOXYPHENYL)-2-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)ETHYL)-5-METHYL-6-(OXAZOL-2-YL)-2,4-DIOXO-1,2-DIHYDROTHIENO[2,3-D]PYRIMIDIN-3(4H)-YL)-2-METHYLPROPANOIC ACID 95.00%
- Packaging5MG
- Price$497.67
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number23961
- Product descriptionND-630 ≥98%
- Packaging1mg
- Price$364
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23961
- Product descriptionND-630 ≥98%
- Packaging5mg
- Price$1181
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-6509
- Product descriptionFirsocostat 99.48%
- Packaging5mg
- Price$270
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6509
- Product descriptionFirsocostat 99.48%
- Packaging10mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6509
- Product descriptionFirsocostat 99.48%
- Packaging25mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6509
- Product descriptionFirsocostat 99.48%
- Packaging50mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6509
- Product descriptionFirsocostat 99.48%
- Packaging100mg
- Price$1150
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10173
- Product descriptionFirsocostat(ND-630,GS-0976) >98%
- Packaging100mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10173
- Product descriptionFirsocostat(ND-630,GS-0976) >98%
- Packaging250mg
- Price$1300
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 9222DU | Firsocostat | 5mg | $1412 | 2021-12-16 | Buy |
| Alichem | 1434635547 | (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2h-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2h)-yl)-2-methylpropanoicacid | 250mg | $995.1 | 2021-12-16 | Buy |
| Alichem | 1434635547 | (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2h-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2h)-yl)-2-methylpropanoicacid | 1g | $2301.75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005695 | (R)-2-(1-(2-(2-METHOXYPHENYL)-2-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)ETHYL)-5-METHYL-6-(OXAZOL-2-YL)-2,4-DIOXO-1,2-DIHYDROTHIENO[2,3-D]PYRIMIDIN-3(4H)-YL)-2-METHYLPROPANOIC ACID 95.00% | 5MG | $497.67 | 2021-12-16 | Buy |
| Cayman Chemical | 23961 | ND-630 ≥98% | 1mg | $364 | 2024-03-01 | Buy |
| Cayman Chemical | 23961 | ND-630 ≥98% | 5mg | $1181 | 2024-03-01 | Buy |
| ChemScene | CS-6509 | Firsocostat 99.48% | 5mg | $270 | 2021-12-16 | Buy |
| ChemScene | CS-6509 | Firsocostat 99.48% | 10mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-6509 | Firsocostat 99.48% | 25mg | $650 | 2021-12-16 | Buy |
| ChemScene | CS-6509 | Firsocostat 99.48% | 50mg | $850 | 2021-12-16 | Buy |
| ChemScene | CS-6509 | Firsocostat 99.48% | 100mg | $1150 | 2021-12-16 | Buy |
| DC Chemicals | DC10173 | Firsocostat(ND-630,GS-0976) >98% | 100mg | $750 | 2021-12-16 | Buy |
| DC Chemicals | DC10173 | Firsocostat(ND-630,GS-0976) >98% | 250mg | $1300 | 2021-12-16 | Buy |
Properties
Boiling point :779.0±70.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:75.0(Max Conc. mg/mL);131.66(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);17.56(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);5.27(Max Conc. mM) form :A crystalline solid
pka :3.66±0.10(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:75.0(Max Conc. mg/mL);131.66(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);17.56(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);5.27(Max Conc. mM) form :A crystalline solid
pka :3.66±0.10(Predicted)
Safety Information
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Description
ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 μM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC50s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.Related product price
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
Chemia Biotechnology（Shanghai） Co., Ltd
Finetech Industry Limited
Zhejiang J&C Biological Technology Co.,Limited
CR Corporation Lomited
