NONACTIN
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- $49 - $1780
- Product name: NONACTIN
- CAS: 6833-84-7
- MF: C40H64O12
- MW: 736.93
- EINECS:229-911-3
- MDL Number:MFCD00043039
- Synonyms:ta-25-m-i ;NONACTIN;NONACTIN, STREPTOMYCES GRISEUS;POLYNACTIN;NONACTIN FROM STREPTOMYCES GRISEUS;NONACTINE, FROM STREPTOMYCES SP.;NONACTIN FROM STREPTOMYCES TSUSIMAENSIS;nonactinfromstreptomycessp.
18 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10MG
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product number8940AJ
- Product descriptionNonactin
- Packaging5mg
- Price$152
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCBL0015615
- Product descriptionNONACTIN 95.00%
- Packaging10MG
- Price$672.09
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7082
- Product descriptionNonactin
- Packaging1mg
- Price$260
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7082
- Product descriptionNonactin
- Packaging5mg
- Price$621
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19468
- Product descriptionNonactin ≥95%
- Packaging5mg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19468
- Product descriptionNonactin ≥95%
- Packaging10mg
- Price$87
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19468
- Product descriptionNonactin ≥95%
- Packaging25mg
- Price$190
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0029218
- Product descriptionNonactin >99.0%
- Packaging1mg
- Price$165
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0029218
- Product descriptionNonactin >99.0%
- Packaging5mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberN2286
- Product descriptionNonactin ≥98% (function tested, HPLC)
- Packaging10mg
- Price$188
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number09877
- Product descriptionAmmonium ionophore I Selectophore
- Packaging50mg
- Price$389
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberN2286
- Product descriptionNonactin ≥98% (function tested, HPLC)
- Packaging100mg
- Price$1110
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number09877
- Product descriptionAmmonium ionophore I Selectophore
- Packaging250mg
- Price$1780
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberN648968
- Product descriptionNonactin(MixturecontainsMonactinandDinactin)(TechnicalGrade)
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number460844
- Product descriptionNonactin
- Packaging1mg
- Price$319
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number256013
- Product descriptionNonactin
- Packaging10mg
- Price$389
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8940AJ | Nonactin | 5mg | $152 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CBL0015615 | NONACTIN 95.00% | 10MG | $672.09 | 2021-12-16 | Buy |
| ApexBio Technology | B7082 | Nonactin | 1mg | $260 | 2021-12-16 | Buy |
| ApexBio Technology | B7082 | Nonactin | 5mg | $621 | 2021-12-16 | Buy |
| Cayman Chemical | 19468 | Nonactin ≥95% | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 19468 | Nonactin ≥95% | 10mg | $87 | 2024-03-01 | Buy |
| Cayman Chemical | 19468 | Nonactin ≥95% | 25mg | $190 | 2024-03-01 | Buy |
| ChemScene | CS-0029218 | Nonactin >99.0% | 1mg | $165 | 2021-12-16 | Buy |
| ChemScene | CS-0029218 | Nonactin >99.0% | 5mg | $450 | 2021-12-16 | Buy |
| Sigma-Aldrich | N2286 | Nonactin ≥98% (function tested, HPLC) | 10mg | $188 | 2024-03-01 | Buy |
| Sigma-Aldrich | 09877 | Ammonium ionophore I Selectophore | 50mg | $389 | 2024-03-01 | Buy |
| Sigma-Aldrich | N2286 | Nonactin ≥98% (function tested, HPLC) | 100mg | $1110 | 2024-03-01 | Buy |
| Sigma-Aldrich | 09877 | Ammonium ionophore I Selectophore | 250mg | $1780 | 2024-03-01 | Buy |
| TRC | N648968 | Nonactin(MixturecontainsMonactinandDinactin)(TechnicalGrade) | 5mg | $110 | 2021-12-16 | Buy |
| Usbiological | 460844 | Nonactin | 1mg | $319 | 2021-12-16 | Buy |
| Usbiological | 256013 | Nonactin | 10mg | $389 | 2021-12-16 | Buy |
Properties
Melting point :147-148°
Boiling point :890.6±65.0 °C(Predicted)
Density :1.11-1.15 g/cm3
storage temp. :2-8°C
solubility :chloroform: soluble10mg/mL
form :White to off-white crystalline solid.
color :white to faint yellow
Sensitive :Moisture Sensitive
Merck :13,6709
BRN :76434
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Boiling point :890.6±65.0 °C(Predicted)
Density :1.11-1.15 g/cm3
storage temp. :2-8°C
solubility :chloroform: soluble10mg/mL
form :White to off-white crystalline solid.
color :white to faint yellow
Sensitive :Moisture Sensitive
Merck :13,6709
BRN :76434
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Safety Information
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Description
Nonactin is a cyclic ionophore and part of the macrotetrolide antibiotics family. The ionophore is commonly produced by several species of Streptomyces which selectively binds K+ and NH4+. Nonactin has been recorded to function by binding a metal ionophore and transporting it across cell membranes for release. The compound can functionally perform this transport due to its conformational flexibility and hydrophobic exterior. The compound forms a natural diastereomer which is required for its antibacterial and binding capacities.At a concentration of 1x10-7 M Nonactin uncoupled oxidative phosphorylation and induced ATP hydrolysis. The compound has been observed to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. In the presence of Thallus acetate, Nonactin has further stimulated the swelling of rat liver mitochondria than thallus acetate alone. It also has inhibited the effects on P170 glycoprotein-mediated efflux of chemotherapeutic agents in MDR cancer cells. Nonactin has been shown to inhibit the production and gene transcription of IL-5 but not of IL-2 or IL-4. Nonactin has also been used as an ammonium ionophore for ammonium ion determination in a potentiometric electrode for biosensor construction as well as in a fluorescent immuno assay to detect K+ ions in pharmaceutical samples.
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