NS 3694
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- $65 - $611
- Product name: NS 3694
- CAS: 426834-38-0
- MF: C15H10ClF3N2O3
- MW: 358.7
- EINECS:
- MDL Number:MFCD00249000
- Synonyms:Apoptosis Inhibitor II, NS3694;Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem;Benzoic acid, 4-chloro-2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-;NS 3694,Inhibitor,Apaf-1,Apoptosis,inhibit,caspase-9,NS-3694,apoptosome inhibitor,NS3694,cytochrome c;NS3694, 10 mM in DMSO
23 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- Sigma-Aldrich
- TRC
Package
- 5mg
- 10mg
- 25mg
- 50mg
- 2x50mg
- ManufacturerAK Scientific
- Product number5674CR
- Product descriptionApoptosis Inhibitor II, NS3694
- Packaging5mg
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPO0001333
- Product descriptionNS3694 95.00%
- Packaging5MG
- Price$408
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4468
- Product descriptionNS3694
- Packaging25mg
- Price$422
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC4468
- Product descriptionNS3694
- Packaging10mg
- Price$204
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC4468
- Product descriptionNS3694
- Packaging10mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4468
- Product descriptionNS3694
- Packaging5mg
- Price$71
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4468
- Product descriptionNS3694
- Packaging5mg
- Price$115
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC4468
- Product descriptionNS3694
- Packaging50mg
- Price$541
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4468
- Product descriptionNS3694
- Packaging50mg
- Price$611
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC4468
- Product descriptionNS3694
- Packaging25mg
- Price$324
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1883
- Product descriptionNS3694 99%
- Packaging2x50mg
- Price$484
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19190
- Product descriptionNS 3694 ≥98%
- Packaging50mg
- Price$523
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number19190
- Product descriptionNS3694 ≥98%
- Packaging50mg
- Price$475
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19190
- Product descriptionNS3694 ≥98%
- Packaging25mg
- Price$286
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19190
- Product descriptionNS 3694 ≥98%
- Packaging25mg
- Price$315
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number19190
- Product descriptionNS3694 ≥98%
- Packaging10mg
- Price$121
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 5674CR | Apoptosis Inhibitor II, NS3694 | 5mg | $170 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | APO0001333 | NS3694 95.00% | 5MG | $408 | 2021-12-16 | Buy |
| ApexBio Technology | C4468 | NS3694 | 25mg | $422 | 2026-05-06 | Buy |
| ApexBio Technology | C4468 | NS3694 | 10mg | $204 | 2026-05-06 | Buy |
| ApexBio Technology | C4468 | NS3694 | 10mg | $138 | 2021-12-16 | Buy |
| ApexBio Technology | C4468 | NS3694 | 5mg | $71 | 2021-12-16 | Buy |
| ApexBio Technology | C4468 | NS3694 | 5mg | $115 | 2026-05-06 | Buy |
| ApexBio Technology | C4468 | NS3694 | 50mg | $541 | 2021-12-16 | Buy |
| ApexBio Technology | C4468 | NS3694 | 50mg | $611 | 2026-05-06 | Buy |
| ApexBio Technology | C4468 | NS3694 | 25mg | $324 | 2021-12-16 | Buy |
| Axon Medchem | Axon1883 | NS3694 99% | 2x50mg | $484 | 2021-12-16 | Buy |
| Cayman Chemical | 19190 | NS 3694 ≥98% | 50mg | $523 | 2026-04-30 | Buy |
| Cayman Chemical | 19190 | NS3694 ≥98% | 50mg | $475 | 2024-03-01 | Buy |
| Cayman Chemical | 19190 | NS3694 ≥98% | 25mg | $286 | 2024-03-01 | Buy |
| Cayman Chemical | 19190 | NS 3694 ≥98% | 25mg | $315 | 2026-04-30 | Buy |
| Cayman Chemical | 19190 | NS3694 ≥98% | 10mg | $121 | 2024-03-01 | Buy |
Properties
storage temp. :2-8°C
solubility :DMSO: 22 mg/mL, soluble
form :solid
color :Off-white to light yellow
InChI :1S/C15H10ClF3N2O3/c16-9-4-5-11(13(22)23)12(7-9)21-14(24)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,22,23)(H2,20,21,24)
InChIKey :GNCZTZCPXFDPLI-UHFFFAOYSA-N
SMILES :FC(F)(F)c1cc(ccc1)NC(=O)Nc2c(ccc(c2)Cl)C(=O)O
solubility :DMSO: 22 mg/mL, soluble
form :solid
color :Off-white to light yellow
InChI :1S/C15H10ClF3N2O3/c16-9-4-5-11(13(22)23)12(7-9)21-14(24)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,22,23)(H2,20,21,24)
InChIKey :GNCZTZCPXFDPLI-UHFFFAOYSA-N
SMILES :FC(F)(F)c1cc(ccc1)NC(=O)Nc2c(ccc(c2)Cl)C(=O)O
Safety Information
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Description
Cytochrome c, which leaks from the mitochondrial intermembrane space into the cytosol, causes oligomerization of apoptotic protease-activating factor 1 (Apaf-1), forming a caspase activation complex known as the apoptosome. NS3694 is a cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation. It blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC50 value of approximately 50 μM. NS3694 prevents the formation of apoptosomes, which prevents the association of procaspases with Apaf-1. It suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine . NS3694 is used to examine the role of apoptosome-mediated caspase activation in cell death.Related product price
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