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ChemicalBook >> CAS DataBase List >> NSC 55712

NSC 55712

NSC 55712 price.
  • $44 - $1428
  • Product name: NSC 55712
  • CAS: 2076-91-7
  • MF: C8H14Cl2N4S3
  • MW: 333.32456
  • EINECS:
  • MDL Number:MFCD25976641
  • Synonyms:NSC 55712;TPT-260 (Dihydrochloride);THIOPHENE-2,5-DIYLBIS(METHYLENE) DICARBAMIMIDOTHIOATE.2HCL;TPT-260 (Dihydrochloride), NSC55712;TPT-260 2HCl;Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride;TPT-260 , NSC55712;NSC 55712 Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride
14 prices
Selected condition:
Brand
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberSYN5349
  • Product descriptionR55
  • Packaging10mg
  • Price$217
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5349
  • Product descriptionR55
  • Packaging50mg
  • Price$757
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3385
  • Product descriptionTPT-260Dihydrochloride
  • Packaging100mg
  • Price$1098
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS019301
  • Product descriptionTPT-260Dihydrochloride 98%
  • Packaging100mg
  • Price$381
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS019301
  • Product descriptionTPT-260Dihydrochloride 98%
  • Packaging250mg
  • Price$572
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS019301
  • Product descriptionTPT-260Dihydrochloride 98%
  • Packaging1g
  • Price$1428
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16079
  • Product descriptionTPT-260 (hydrochloride) ≥95%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16079
  • Product descriptionTPT-260 (hydrochloride) ≥95%
  • Packaging5mg
  • Price$140
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16079
  • Product descriptionTPT-260 (hydrochloride) ≥95%
  • Packaging10mg
  • Price$235
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16079
  • Product descriptionTPT-260 (hydrochloride) ≥95%
  • Packaging25mg
  • Price$479
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31002719
  • Product descriptionTPT-260Dihydrochloride 98+%
  • Packaging5mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31002719
  • Product descriptionTPT-260Dihydrochloride 98+%
  • Packaging50mg
  • Price$293
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7713
  • Product descriptionTPT-2602HCl(NSC55712) >98%
  • Packaging100mg
  • Price$375
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7713
  • Product descriptionTPT-2602HCl(NSC55712) >98%
  • Packaging250mg
  • Price$750
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5349 R55 10mg $217 2021-12-16 Buy
AK Scientific SYN5349 R55 50mg $757 2021-12-16 Buy
ApexBio Technology B3385 TPT-260Dihydrochloride 100mg $1098 2021-12-16 Buy
Arctom AS019301 TPT-260Dihydrochloride 98% 100mg $381 2021-12-16 Buy
Arctom AS019301 TPT-260Dihydrochloride 98% 250mg $572 2021-12-16 Buy
Arctom AS019301 TPT-260Dihydrochloride 98% 1g $1428 2021-12-16 Buy
Cayman Chemical 16079 TPT-260 (hydrochloride) ≥95% 1mg $44 2024-03-01 Buy
Cayman Chemical 16079 TPT-260 (hydrochloride) ≥95% 5mg $140 2024-03-01 Buy
Cayman Chemical 16079 TPT-260 (hydrochloride) ≥95% 10mg $235 2024-03-01 Buy
Cayman Chemical 16079 TPT-260 (hydrochloride) ≥95% 25mg $479 2024-03-01 Buy
Crysdot CD31002719 TPT-260Dihydrochloride 98+% 5mg $59 2021-12-16 Buy
Crysdot CD31002719 TPT-260Dihydrochloride 98+% 50mg $293 2021-12-16 Buy
DC Chemicals DC7713 TPT-2602HCl(NSC55712) >98% 100mg $375 2021-12-16 Buy
DC Chemicals DC7713 TPT-2602HCl(NSC55712) >98% 250mg $750 2021-12-16 Buy

Properties

Melting point :210℃ (Decomposition)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO:62.5(Max Conc. mg/mL);240.02(Max Conc. mM)
form :A crystalline solid

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 μM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.