NSC 600157
|
- $31 - $1700
- Product name: NSC 600157
- CAS: 31083-55-3
- MF: C15H9NO2
- MW: 235.24
- EINECS:
- MDL Number:MFCD00435709
- Synonyms:2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione;2-(3-Pyridylmethylene)-1,3-indandione;NSC 600157;PRT 4165(NSC 600157);PRT 4165; PRT-4165; NSC600157; NSC-600157; NSC 600157; 2-(pyridin-3-ylmethylidene)indene-1,3-dione;1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)-;PRT4165 >=98% (HPLC)
52 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- Usbiological
Package
- 10mg
- 25mg
- 50mg
- 10mM*1mLinDMSO
- 5mg
- 10
- 50
- 100mg
- 250.00mg
- 250mg
- 1g
- 1.00g
- 2.5g
- 5.00g
- 5G
- Manufactureraablocks
- Product numberAA0031ZN
- Product description2-(3-PYRIDINYLMETHYLENE)-1H-INDENE-1,3(2H)-DIONE 98%
- Packaging100mg
- Price$31
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0031ZN
- Product description2-(3-PYRIDINYLMETHYLENE)-1H-INDENE-1,3(2H)-DIONE 98%
- Packaging250mg
- Price$49
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0031ZN
- Product description2-(3-PYRIDINYLMETHYLENE)-1H-INDENE-1,3(2H)-DIONE 98%
- Packaging1g
- Price$192
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15361
- Product descriptionNSC 600157 98%
- Packaging1G
- Price$345
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15361
- Product descriptionNSC 600157 98%
- Packaging5G
- Price$1030
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberSYN5089
- Product descriptionPRT4165
- Packaging50mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2917CB
- Product description1,3-Indandione,2-(3-pyridylmethylene)-
- Packaging100mg
- Price$143
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA295342
- Product descriptionPRT4165 98+%
- Packaging25mg
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA295342
- Product descriptionPRT4165 98+%
- Packaging50mg
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA295342
- Product descriptionPRT4165 98+%
- Packaging100mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA295342
- Product descriptionPRT4165 98+%
- Packaging5mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA295342
- Product descriptionPRT4165 98+%
- Packaging10mg
- Price$59
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA295342
- Product descriptionPRT4165 98+%
- Packaging1g
- Price$1700
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5797
- Product descriptionPRT 4165
- Packaging50mg
- Price$180
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5797
- Product descriptionPRT 4165
- Packaging10mg
- Price$60
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-19817
- Product descriptionPRT4165 98.0%
- Packaging5mg
- Price$48
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0031ZN | 2-(3-PYRIDINYLMETHYLENE)-1H-INDENE-1,3(2H)-DIONE 98% | 100mg | $31 | 2026-05-28 | Buy |
| aablocks | AA0031ZN | 2-(3-PYRIDINYLMETHYLENE)-1H-INDENE-1,3(2H)-DIONE 98% | 250mg | $49 | 2026-05-28 | Buy |
| aablocks | AA0031ZN | 2-(3-PYRIDINYLMETHYLENE)-1H-INDENE-1,3(2H)-DIONE 98% | 1g | $192 | 2026-05-28 | Buy |
| ACHEMBLOCK | M15361 | NSC 600157 98% | 1G | $345 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15361 | NSC 600157 98% | 5G | $1030 | 2026-05-27 | Buy |
| AK Scientific | SYN5089 | PRT4165 | 50mg | $400 | 2021-12-16 | Buy |
| AK Scientific | 2917CB | 1,3-Indandione,2-(3-pyridylmethylene)- | 100mg | $143 | 2021-12-16 | Buy |
| Ambeed | A295342 | PRT4165 98+% | 25mg | $119 | 2021-12-16 | Buy |
| Ambeed | A295342 | PRT4165 98+% | 50mg | $154 | 2021-12-16 | Buy |
| Ambeed | A295342 | PRT4165 98+% | 100mg | $200 | 2021-12-16 | Buy |
| Ambeed | A295342 | PRT4165 98+% | 5mg | $35 | 2021-12-16 | Buy |
| Ambeed | A295342 | PRT4165 98+% | 10mg | $59 | 2021-12-16 | Buy |
| Ambeed | A295342 | PRT4165 98+% | 1g | $1700 | 2021-12-16 | Buy |
| ApexBio Technology | B5797 | PRT 4165 | 50mg | $180 | 2026-05-06 | Buy |
| ApexBio Technology | B5797 | PRT 4165 | 10mg | $60 | 2026-05-06 | Buy |
| Arctom | HY-19817 | PRT4165 98.0% | 5mg | $48 | 2026-05-26 | Buy |
Properties
Melting point :154-161 °C(Solv: ethanol (64-17-5))
Boiling point :377.63°C (rough estimate)
Density :1.1757 (rough estimate)
refractive index :1.6231 (estimate)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :3.24±0.12(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H
InChIKey :OMHZFEWYVFWVLI-UHFFFAOYSA-N
SMILES :C1(=O)C2=C(C=CC=C2)C(=O)/C/1=C/C1=CC=CN=C1
Boiling point :377.63°C (rough estimate)
Density :1.1757 (rough estimate)
refractive index :1.6231 (estimate)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :3.24±0.12(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H
InChIKey :OMHZFEWYVFWVLI-UHFFFAOYSA-N
SMILES :C1(=O)C2=C(C=CC=C2)C(=O)/C/1=C/C1=CC=CN=C1
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
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Description
BMI1/RING1A and BMI1/RNF2 are E3 ubiquitin ligase complexes that mediate the monoubiquitination of histone 2A (H2A). This is an essential function of polycomb repressive complex 1 (PRC1). PRT4165 is an inhibitor of the ubiquitin ligase activity of PRC1. It blocks BMI1/RING1A self-ubiquitination (IC50 = 3.9 μM), as well as polyubiquitination of topoisomerase 2α in cells. PRT4165 inhibits ubiquitination of H2A by either RNF2 or RING1. Through these actions, PRT4165 prevents the accumulation of detectable ubiquitin at DNA double-strand breaks, the retention of response proteins around breaks, and the repair of breaks.Related product price
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