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ChemicalBook >> CAS DataBase List >> NUTLIN-3

NUTLIN-3

$35.24 - $3205
Product name: NUTLIN-3
CAS: 548472-68-0
MF: C30H30Cl2N4O4
MW: 581.49
EINECS:200-258-5
MDL Number:MFCD07784509
Synonyms:(+/-)-4-[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE;NUTLIN-3;2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-;4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one;Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-;4-[4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-Methoxy-phenyl)-4,5-dihydro-iMidazole-1-carbonyl]-piperazin-2-one;Nutlin-3, >=98%;NUTLIN-3 (Free base)

Price87 Properties Safety Information Description

87 prices

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Brand

aablocks
ACHEMBLOCK
AK Scientific
American Custom Chemicals Corporation
ApexBio Technology
Arctom
AvaChem
Axon Medchem
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Iris Biotech GmbH
Matrix Scientific
Sigma-Aldrich
Synthonix
TCI Chemical
Tocris
TRC
Usbiological

Package

1mg
5.00mg
5mg
10.00mg
0.01g
10mg
2x5mg
0.025g
25mg
50.00mg
50mg
0.05g
100mg
10
200mg
0.1g
50
10mM*1mLinDMSO(Solid+Solvent)
1G
5g
250mg
0.25g
10mM*1mLinDMSO(Solution)

Manufactureraablocks
Product numberAA00DED9
Product description2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel- 98%
Packaging5mg
Price$48
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00DED9
Product description2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel- 98%
Packaging1mg
Price$36
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00DED9
Product description2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel- 98%
Packaging10mg
Price$71
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00DED9
Product description2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel- 98%
Packaging50mg
Price$162
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00DED9
Product description2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel- >98%
Packaging100mg
Price$180
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00DED9
Product description2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel- 98%
Packaging250mg
Price$314
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberV143533
Product description4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one 98%
Packaging250MG
Price$405
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberV143533
Product description4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one 98%
Packaging1G
Price$1105
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product number1959AH
Product descriptionNutlin-3
Packaging25mg
Price$248
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0008268
Product descriptionNUTLIN-3 95.00%
Packaging1MG
Price$579.69
Updated2021-12-16
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ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0008268
Product descriptionNUTLIN-3 95.00%
Packaging10MG
Price$817.39
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB6058
Product description(±)-Nutlin-3
Packaging50mg
Price$328
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberB6058
Product description(±)-Nutlin-3
Packaging10mg
Price$121
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberB6058
Product description(±)-Nutlin-3
Packaging5mg
Price$72
Updated2026-05-06
Buy

ManufacturerArctom
Product numberBD-A140511
Product descriptionNutlin-3 98%
Packaging10mg
Price$73
Updated2026-05-26
Buy

ManufacturerArctom
Product numberBD-A140511
Product descriptionNutlin-3 98%
Packaging1mg
Price$37
Updated2026-05-26
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA00DED9	2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel- 98%	5mg	$48	2026-05-28	Buy
aablocks	AA00DED9	2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel- 98%	1mg	$36	2026-05-28	Buy
aablocks	AA00DED9	2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel- 98%	10mg	$71	2026-05-28	Buy
aablocks	AA00DED9	2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel- 98%	50mg	$162	2026-05-28	Buy
aablocks	AA00DED9	2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel- >98%	100mg	$180	2026-05-28	Buy
aablocks	AA00DED9	2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel- 98%	250mg	$314	2026-05-28	Buy
ACHEMBLOCK	V143533	4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one 98%	250MG	$405	2026-05-27	Buy
ACHEMBLOCK	V143533	4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one 98%	1G	$1105	2026-05-27	Buy
AK Scientific	1959AH	Nutlin-3	25mg	$248	2021-12-16	Buy
American Custom Chemicals Corporation	API0008268	NUTLIN-3 95.00%	1MG	$579.69	2021-12-16	Buy
American Custom Chemicals Corporation	API0008268	NUTLIN-3 95.00%	10MG	$817.39	2021-12-16	Buy
ApexBio Technology	B6058	(±)-Nutlin-3	50mg	$328	2026-05-06	Buy
ApexBio Technology	B6058	(±)-Nutlin-3	10mg	$121	2026-05-06	Buy
ApexBio Technology	B6058	(±)-Nutlin-3	5mg	$72	2026-05-06	Buy
Arctom	BD-A140511	Nutlin-3 98%	10mg	$73	2026-05-26	Buy
Arctom	BD-A140511	Nutlin-3 98%	1mg	$37	2026-05-26	Buy

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Properties

Melting point :>132oC (dec.)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: 20 mg/mL, soluble
form :solid
pka :14.35±0.20(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey :BDUHCSBCVGXTJM-UHFFFAOYSA-N
SMILES :N1CCN(C(N2C(C3=CC=C(OC)C=C3OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]2C2=CC=C(Cl)C=C2)=O)CC1=O |&1:20,28,r|

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

(+)-Nutlin-3 is a potent inhibitor of p53-Mdm2 interaction.3 (+)-Nutlin-3 is arbitrarily referred to as enantiomer b because it appears as the second peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. It is 150-fold less potent as an inhibitor of p53-Mdm2 interaction than ()-nutlin-3, demonstrating an IC50 value of 13.6 M. This inactive enantiomer can serve as a useful control for non-MDM2 related cellular activities.

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Suppliers and manufacturers

Shanghai Boyle Chemical Co., Ltd. Chembest Research Laboratories Limited Goodee Pharma Co., Ltd. Shanghai civi chemical technology co.,Ltd NCE Biomedical Co.,Ltd. Shanghai Jian Chao Chemical Technology Co., Ltd. Haoyuan Chemexpress Co., Ltd. Shanghai Aladdin Bio-Chem Technology Co.,LTD MedChemexpress LLC AdooQ BioScience, LLC

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NUTLIN-3

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