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ChemicalBook >> CAS DataBase List >> Onalespib

Onalespib

Onalespib price.
  • $33 - $2841
  • Product name: Onalespib
  • CAS: 912999-49-6
  • MF: C24H31N3O3
  • MW: 409.52
  • EINECS:
  • MDL Number:MFCD18633198
  • Synonyms:(2,4-dihydroxy-5-isopropylphenyl)(5-((4-Methylpiperazin-1-yl)Methyl)isoindolin-2-yl)Methanone;4-({5-[(4-Methylpiperazin-1-yl)Methyl]-2,3-dihydro-1H-isoindol-2-yl}carbonyl)-6-(propan-2-yl)benzene-1,3-diol;[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone;Onalespib;Onalespib (AT13387);[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone AT13387;AT13387, >=98%;Onalespib Lactate
Price62 Properties Safety Information Description
62 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10mM(1mLinDMSO)
  • 10mM*1mLinDMSO(Solution)
  • 2mg
  • 10mM*1mLinDMSO
  • 200mg
  • 500mg
  • 10g
  • 10mM(in1mLDMSO)
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • Manufactureraablocks
  • Product numberAA00GTYA
  • Product description[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone ≥98%
  • Packaging1mg
  • Price$49
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00GTYA
  • Product description[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98%
  • Packaging5mg
  • Price$58
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00GTYA
  • Product description[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98%
  • Packaging25mg
  • Price$128
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00GTYA
  • Product description[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98%
  • Packaging50mg
  • Price$203
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00GTYA
  • Product description[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98%
  • Packaging100mg
  • Price$324
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00GTYA
  • Product description[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone ≥98%
  • Packaging250mg
  • Price$693
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberX212395
  • Product descriptionOnalespib (AT13387) 97%
  • Packaging50MG
  • Price$220
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberX212395
  • Product descriptionOnalespib (AT13387) 97%
  • Packaging100MG
  • Price$350
  • Updated2026-05-27
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging100mg
  • Price$251
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging50mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging25mg
  • Price$111
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging5mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging1mg
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging250mg
  • Price$501
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging1g
  • Price$1503
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00GTYA [1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone ≥98% 1mg $49 2026-05-28 Buy
aablocks AA00GTYA [1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98% 5mg $58 2026-05-28 Buy
aablocks AA00GTYA [1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98% 25mg $128 2026-05-28 Buy
aablocks AA00GTYA [1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98% 50mg $203 2026-05-28 Buy
aablocks AA00GTYA [1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone 98% 100mg $324 2026-05-28 Buy
aablocks AA00GTYA [1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone ≥98% 250mg $693 2026-05-28 Buy
ACHEMBLOCK X212395 Onalespib (AT13387) 97% 50MG $220 2026-05-27 Buy
ACHEMBLOCK X212395 Onalespib (AT13387) 97% 100MG $350 2026-05-27 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 100mg $251 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 50mg $144 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 25mg $111 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 5mg $65 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 1mg $33 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 10mg $85 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 250mg $501 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 1g $1503 2021-12-16 Buy
Next Last

Properties

Boiling point :605.7±55.0 °C(Predicted)
Density :1.237
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥13.25 mg/mL in DMSO; ≥47.7 mg/mL in EtOH with ultrasonic
form :solid
pka :8.50±0.48(Predicted)
color :White to off-white
InChI :InChI=1S/C24H31N3O3/c1-16(2)20-11-21(23(29)12-22(20)28)24(30)27-14-18-5-4-17(10-19(18)15-27)13-26-8-6-25(3)7-9-26/h4-5,10-12,16,28-29H,6-9,13-15H2,1-3H3
InChIKey :IFRGXKKQHBVPCQ-UHFFFAOYSA-N
SMILES :C(N1CC2=C(C1)C=CC(CN1CCN(C)CC1)=C2)(C1=CC(C(C)C)=C(O)C=C1O)=O

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Onalespib, also known as AT13387, is a selective inhibitor of Hsp90 (IC50 = 18 nM). It induces the degradation of specific Hsp90 client proteins, including mutant EGFR, for up to seven days in tumor cell lines in vitro and up to three days in vivo. Onalespib is retained in tumor xenografts and is efficacious in a range of xenograft models. It differs from other HSP90 inhibitors in its longer duration of target inhibition and its favorable toxicity profile in phase I studies in patients with refractory solid tumors.

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Suppliers and manufacturers

Shanghai Changyu Medical Technology Co. Ltd. Shanghai SuperLan Chemcial Technique Centre Shanghai Boyle Chemical Co., Ltd. Jinan Trio PharmaTech Co., Ltd. Dalian Meilun Biotech Co., Ltd. NCE Biomedical Co.,Ltd. Haoyuan Chemexpress Co., Ltd. Shanghai Aladdin Bio-Chem Technology Co.,LTD Shanghai Witofly Chemical Co.,Ltd AdooQ BioScience, LLC