PFK-158
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- $37 - $1470
- Product name: PFK-158
- CAS: 1462249-75-7
- MF: C18H11F3N2O
- MW: 328.29
- EINECS:
- MDL Number:
- Synonyms:PFK-158;PFK-158, ACT-PFK-158;(2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one;PFK-158;PFK 158;PFK-158 free base;2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-;(E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one;p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
39 prices
Selected condition：
Brand
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- Crysdot
- DC Chemicals
- Sigma-Aldrich
Package
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 250mg
- 10mM*1mLinDMSO
- 10mg
- 5mg
- 25mg
- 50mg
- 100MG
- 1G
- 1mL(10mMinDMSO)
- ManufacturerACHEMBLOCK
- Product numberP51264
- Product descriptionPFK-158 95%
- Packaging100MG
- Price$210
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51264
- Product descriptionPFK-158 95%
- Packaging1G
- Price$1260
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2917DV
- Product descriptionCID71730058
- Packaging25mg
- Price$343
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberBA2774
- Product descriptionPFK-158
- Packaging50mg
- Price$315
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberBA2774
- Product descriptionPFK-158
- Packaging100mg
- Price$495
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberBA2774
- Product descriptionPFK-158
- Packaging5mg
- Price$72
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberBA2774
- Product descriptionPFK-158
- Packaging1mL(10mMinDMSO)
- Price$79
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberBA2774
- Product descriptionPFK-158
- Packaging10mg
- Price$117
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-12203
- Product descriptionPFK-158 98.95%
- Packaging10mg
- Price$124
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12203
- Product descriptionPFK-158 98.95%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$80
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12203
- Product descriptionPFK-158 98.95%
- Packaging10mM*1mLinDMSO(Solution)
- Price$84
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12203
- Product descriptionPFK-158 98.95%
- Packaging5mg
- Price$76
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12203
- Product descriptionPFK-158 98.95%
- Packaging1mg
- Price$37
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12203
- Product descriptionPFK-158 98.95%
- Packaging100mg
- Price$523
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12203
- Product descriptionPFK-158 98.95%
- Packaging50mg
- Price$333
- Updated2026-05-26
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2542
- Product descriptionPFK158
- Packaging50mg
- Price$297
- Updated2026-05-19
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | P51264 | PFK-158 95% | 100MG | $210 | 2026-05-27 | Buy |
| ACHEMBLOCK | P51264 | PFK-158 95% | 1G | $1260 | 2026-05-27 | Buy |
| AK Scientific | 2917DV | CID71730058 | 25mg | $343 | 2021-12-16 | Buy |
| ApexBio Technology | BA2774 | PFK-158 | 50mg | $315 | 2026-05-06 | Buy |
| ApexBio Technology | BA2774 | PFK-158 | 100mg | $495 | 2026-05-06 | Buy |
| ApexBio Technology | BA2774 | PFK-158 | 5mg | $72 | 2026-05-06 | Buy |
| ApexBio Technology | BA2774 | PFK-158 | 1mL(10mMinDMSO) | $79 | 2026-05-06 | Buy |
| ApexBio Technology | BA2774 | PFK-158 | 10mg | $117 | 2026-05-06 | Buy |
| Arctom | HY-12203 | PFK-158 98.95% | 10mg | $124 | 2026-05-26 | Buy |
| Arctom | HY-12203 | PFK-158 98.95% | 10mM*1mLinDMSO(Solid+Solvent) | $80 | 2026-05-26 | Buy |
| Arctom | HY-12203 | PFK-158 98.95% | 10mM*1mLinDMSO(Solution) | $84 | 2026-05-26 | Buy |
| Arctom | HY-12203 | PFK-158 98.95% | 5mg | $76 | 2026-05-26 | Buy |
| Arctom | HY-12203 | PFK-158 98.95% | 1mg | $37 | 2026-05-26 | Buy |
| Arctom | HY-12203 | PFK-158 98.95% | 100mg | $523 | 2026-05-26 | Buy |
| Arctom | HY-12203 | PFK-158 98.95% | 50mg | $333 | 2026-05-26 | Buy |
| Axon Medchem | Axon2542 | PFK158 | 50mg | $297 | 2026-05-19 | Buy |
Properties
Boiling point :466.3±45.0 °C(Predicted)
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
form :A crystalline solid
pka :2.46±0.10(Predicted)
color :White to light yellow
InChI :1S/C18H11F3N2O/c19-18(20,21)14-3-1-12-2-4-15(23-16(12)11-14)5-6-17(24)13-7-9-22-10-8-13/h1-11H/b6-5+
InChIKey :IAJOMYABKVAZCN-AATRIKPKSA-N
SMILES :O=C(/C=C/C1=NC2=C(C=CC(C(F)(F)F)=C2)C=C1)C3=CC=NC=C3
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
form :A crystalline solid
pka :2.46±0.10(Predicted)
color :White to light yellow
InChI :1S/C18H11F3N2O/c19-18(20,21)14-3-1-12-2-4-15(23-16(12)11-14)5-6-17(24)13-7-9-22-10-8-13/h1-11H/b6-5+
InChIKey :IAJOMYABKVAZCN-AATRIKPKSA-N
SMILES :O=C(/C=C/C1=NC2=C(C=CC(C(F)(F)F)=C2)C=C1)C3=CC=NC=C3
Safety Information
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Description
PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 137 nM for human recombinant PFKFB3). It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.Suppliers and manufacturers
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Shanghai Boyle Chemical Co., Ltd.
