PFK-158
|
- $12 - $1470
- Product name: PFK-158
- CAS: 1462249-75-7
- MF: C18H11F3N2O
- MW: 328.29
- EINECS:
- MDL Number:
- Synonyms:PFK-158;PFK-158, ACT-PFK-158;(2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one;PFK-158;PFK 158;PFK-158 free base;2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-;(E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one;p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
44 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
Package
- 10mM*1mLinDMSO
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 10mM*1mLinDMSO(Solution)
- 1G
- 1mL(10mMinDMSO)
- 10mM*1mLinDMSO(Solid+Solvent)
- Manufactureraablocks
- Product numberAA00ABQ5
- Product descriptionPFK-158 98%
- Packaging1mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABQ5
- Product descriptionPFK-158 98%
- Packaging5mg
- Price$25
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABQ5
- Product descriptionPFK-158 98%
- Packaging10mg
- Price$34
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABQ5
- Product descriptionPFK-158 98%
- Packaging25mg
- Price$55
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABQ5
- Product descriptionPFK-158 98%
- Packaging50mg
- Price$91
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABQ5
- Product descriptionPFK-158 98%
- Packaging100mg
- Price$146
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51264
- Product descriptionPFK-158 95%
- Packaging1G
- Price$1260
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51264
- Product descriptionPFK-158 95%
- Packaging100MG
- Price$210
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2917DV
- Product descriptionCID71730058
- Packaging25mg
- Price$343
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberBA2774
- Product descriptionPFK-158
- Packaging50mg
- Price$315
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberBA2774
- Product descriptionPFK-158
- Packaging100mg
- Price$495
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberBA2774
- Product descriptionPFK-158
- Packaging10mg
- Price$117
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberBA2774
- Product descriptionPFK-158
- Packaging1mL(10mMinDMSO)
- Price$79
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberBA2774
- Product descriptionPFK-158
- Packaging5mg
- Price$72
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-12203
- Product descriptionPFK-158 98.95%
- Packaging5mg
- Price$76
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12203
- Product descriptionPFK-158 98.95%
- Packaging1mg
- Price$37
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00ABQ5 | PFK-158 98% | 1mg | $12 | 2026-05-28 | Buy |
| aablocks | AA00ABQ5 | PFK-158 98% | 5mg | $25 | 2026-05-28 | Buy |
| aablocks | AA00ABQ5 | PFK-158 98% | 10mg | $34 | 2026-05-28 | Buy |
| aablocks | AA00ABQ5 | PFK-158 98% | 25mg | $55 | 2026-05-28 | Buy |
| aablocks | AA00ABQ5 | PFK-158 98% | 50mg | $91 | 2026-05-28 | Buy |
| aablocks | AA00ABQ5 | PFK-158 98% | 100mg | $146 | 2026-05-28 | Buy |
| ACHEMBLOCK | P51264 | PFK-158 95% | 1G | $1260 | 2026-05-27 | Buy |
| ACHEMBLOCK | P51264 | PFK-158 95% | 100MG | $210 | 2026-05-27 | Buy |
| AK Scientific | 2917DV | CID71730058 | 25mg | $343 | 2021-12-16 | Buy |
| ApexBio Technology | BA2774 | PFK-158 | 50mg | $315 | 2026-05-06 | Buy |
| ApexBio Technology | BA2774 | PFK-158 | 100mg | $495 | 2026-05-06 | Buy |
| ApexBio Technology | BA2774 | PFK-158 | 10mg | $117 | 2026-05-06 | Buy |
| ApexBio Technology | BA2774 | PFK-158 | 1mL(10mMinDMSO) | $79 | 2026-05-06 | Buy |
| ApexBio Technology | BA2774 | PFK-158 | 5mg | $72 | 2026-05-06 | Buy |
| Arctom | HY-12203 | PFK-158 98.95% | 5mg | $76 | 2026-05-26 | Buy |
| Arctom | HY-12203 | PFK-158 98.95% | 1mg | $37 | 2026-05-26 | Buy |
Properties
Boiling point :466.3±45.0 °C(Predicted)
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
form :A crystalline solid
pka :2.46±0.10(Predicted)
color :White to light yellow
InChI :1S/C18H11F3N2O/c19-18(20,21)14-3-1-12-2-4-15(23-16(12)11-14)5-6-17(24)13-7-9-22-10-8-13/h1-11H/b6-5+
InChIKey :IAJOMYABKVAZCN-AATRIKPKSA-N
SMILES :O=C(/C=C/C1=NC2=C(C=CC(C(F)(F)F)=C2)C=C1)C3=CC=NC=C3
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
form :A crystalline solid
pka :2.46±0.10(Predicted)
color :White to light yellow
InChI :1S/C18H11F3N2O/c19-18(20,21)14-3-1-12-2-4-15(23-16(12)11-14)5-6-17(24)13-7-9-22-10-8-13/h1-11H/b6-5+
InChIKey :IAJOMYABKVAZCN-AATRIKPKSA-N
SMILES :O=C(/C=C/C1=NC2=C(C=CC(C(F)(F)F)=C2)C=C1)C3=CC=NC=C3
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 137 nM for human recombinant PFKFB3). It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
Bide Pharmatech Ltd.
AdooQ Bioscience CHINA
Shanghai JiYi Biotechnology Co. Ltd.
Hunan Cangood Medical Technology Ltd.
Shanghai Lollane Biological Technology Co.,Ltd.
Shanghaizehan biopharma technology co., Ltd.
Shanghai EFE Biological Technology Co., Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.
Shanghai Chaolan Chemical Technology Center