PeraMpanel
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- $81 - $2990
- Product name: PeraMpanel
- CAS: 380917-97-5
- MF: C23H15N3O
- MW: 349.38
- EINECS:691-969-4
- MDL Number:MFCD19443693
- Synonyms:3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one;2-(6'-Oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile;Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)-;ER 155055-90 Perampanel;2-(2-oxo-1-phenyl-5-pyridin-2- ylpyridin-3-yl)benzonitrile;Perampane,Perampanel Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl);PeraMpanel;E 2007
9 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- Biosynth Carbosynth
- Cayman Chemical
- Chemtos
- DC Chemicals
- Medical Isotopes, Inc.
Package
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberRDL0017883
- Product descriptionPERAMPANEL-D5 95.00%
- Packaging5MG
- Price$498
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFP65127
- Product descriptionPerampanel
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFP65127
- Product descriptionPerampanel
- Packaging50mg
- Price$437.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number23003
- Product descriptionPerampanel
- Packaging5mg
- Price$81
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23003
- Product descriptionPerampanel ≥98%
- Packaging10mg
- Price$152
- Updated2024-03-01
- Buy
- ManufacturerChemtos
- Product numberP-5279
- Product descriptionPerampanellabeled13C6(C-III)
- Packaging25mg
- Price$2990
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7226
- Product descriptionPerampanel(E2007） >98%
- Packaging100mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7226
- Product descriptionPerampanel(E2007） >98%
- Packaging250mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number61029
- Product descriptionPerampanel
- Packaging100mg
- Price$2120
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | RDL0017883 | PERAMPANEL-D5 95.00% | 5MG | $498 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FP65127 | Perampanel | 10mg | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FP65127 | Perampanel | 50mg | $437.5 | 2021-12-16 | Buy |
| Cayman Chemical | 23003 | Perampanel | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 23003 | Perampanel ≥98% | 10mg | $152 | 2024-03-01 | Buy |
| Chemtos | P-5279 | Perampanellabeled13C6(C-III) | 25mg | $2990 | 2021-12-16 | Buy |
| DC Chemicals | DC7226 | Perampanel(E2007） >98% | 100mg | $400 | 2021-12-16 | Buy |
| DC Chemicals | DC7226 | Perampanel(E2007） >98% | 250mg | $700 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 61029 | Perampanel | 100mg | $2120 | 2021-12-16 | Buy |
Properties
Boiling point :619.1±55.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
solubility :Soluble in DMSO
form :Powder
pka :4.73±0.19(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
solubility :Soluble in DMSO
form :Powder
pka :4.73±0.19(Predicted)
Safety Information
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Description
In October 2012, the US FDA approved perampanel for the treatment of partial onset seizures in epileptic patients who are at least 12 years old. Perampanel is the first AMPA receptor antagonist to receive FDA approval as an AED. AMPA glutamate receptors are found primarily on postsynaptic neurons in the brain. As a selective, noncompetitive antagonist of AMPA, parampanel prevents ion channel opening and reduces propagation of action potential. Parampanel was discovered through lead optimization of a commercially available compound, 2,4-diphenyl-4H-[1,3,4]oxadiazin-5-one, which was identified by high-throughput screening of a compound collection employing a rat cortical neuron AMPA-induced cell-death assay. Modifications of aromatic rings at positions 1, 3, and 5 while changing the core to pyridone led to parampanel which inhibited AMPA-induced calcium influx (IC50=60 nM). Parampanel had a minimum effective oral dose of 2 mg/kg in an AMPA-induced mouse seizure model. The synthesis of parampanel was accomplished via a 6-step route utilizing Suzuki–Miyaura couplings and modified Ullmann reactions for incorporation of aryl groups.More related product prices
Levetiracetam Unii-4bmh7izt98 Entacapone Tafluprost 381725-49-1 3,5-Dibromopyridine 2-Cyanophenylboronic acid Phenylboronic acid 3,5-Dimethoxypyridine 1-Phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-2-one 2-Bromobenzonitrile 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE 4406-77-3 2,5-Dibromopyridine 5-Bromo-2-methoxypyridine 172732-52-4 2,5-Dimethoxy PyridineRelated product price
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