Welcome to chemicalbook!
China English Japan Germany
010-86108875
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structure Search
RFQ
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook Sign in

Welcome back!

RFQ
skype
MY Account
Top
ChemicalBook >> CAS DataBase List >> Entacapone

Entacapone

Entacapone price.
  • $5 - $1957.73
  • Product name: Entacapone
  • CAS: 130929-57-6
  • MF: C14H15N3O5
  • MW: 305.29
  • EINECS:212-686-0
  • MDL Number:MFCD00866580
  • Synonyms:(E)-2-Cyano-3-(3，4-dihydroxy-5-nitrophenyl)-N，N-diethyl-2-pmpenamide;Entacapone (150 mg);(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enaMide;2-PropenaMide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-;Entacapone (isomer E);(E)-2-cyano-3-(5-(dihydroxyamino)-3,4-dioxocyclohexa-1,5-dienyl)-N,N-diethylacrylamide;ENTACAPONE;2-cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-n,n-diethyl-prop-2-enamide
Price91 Properties Safety Information Description
91 prices
Selected condition：
Brand
  • aablocks
  • AccelPharmtech
  • Adipogen Life Sciences
  • AHH
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Thermo Scientific Chemicals
  • Tocris
  • TRC
  • Usbiological
Package
  • 10mM*1mLinDMSO
  • 10g
  • 50g
  • 100g
  • 250g
  • 500g
  • y0001249
  • 10
  • 200mg
  • 1 g
  • 160 mg
  • 50
  • 250 mg
  • 5mg
  • 10mg
  • 10mM(in1mLDMSO)
  • 25mg
  • 50mg
  • 100mg
  • 0.1g
  • 250mg
  • 10mM(in 1mL DMSO)
  • 1g
  • 5g
  • 25g
  • 10mM(1mLinDMSO)
  • Manufactureraablocks
  • Product numberAA000C3Q
  • Product description(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 95%
  • Packaging10mg
  • Price$8
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000C3Q
  • Product description(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 95%
  • Packaging25mg
  • Price$10
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000C3Q
  • Product description(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide ≥98%
  • Packaging50mg
  • Price$10
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000C3Q
  • Product description(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 95%
  • Packaging100mg
  • Price$15
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000C3Q
  • Product description(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide ≥98%
  • Packaging250mg
  • Price$16
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000C3Q
  • Product description(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 95%
  • Packaging1g
  • Price$30
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000C3Q
  • Product description(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 95%
  • Packaging5g
  • Price$98
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000C3Q
  • Product description(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 98%
  • Packaging25g
  • Price$363
  • Updated2026-05-25
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberAT6629
  • Product descriptionentacapone 99.00%
  • Packaging1G
  • Price$270
  • Updated2026-05-21
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3708-M025
  • Product descriptionEntacapone ≥98%(HPLC)
  • Packaging25mg
  • Price$60
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3708-M005
  • Product descriptionEntacapone ≥98%(HPLC)
  • Packaging5mg
  • Price$25
  • Updated2026-05-06
  • Buy
  • ManufacturerAHH
  • Product numberMT-50794
  • Product descriptionEntacapone 97%
  • Packaging0.1g
  • Price$330
  • Updated2026-05-26
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ90011
  • Product descriptionEntacapone 95%
  • Packaging1g
  • Price$495
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberG843
  • Product descriptionEntacapone 98%(HPLC)
  • Packaging25g
  • Price$518
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberG843
  • Product descriptionEntacapone 98%(HPLC)
  • Packaging100mg
  • Price$25
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberG843
  • Product descriptionEntacapone 98%(HPLC)
  • Packaging250mg
  • Price$30
  • Updated2026-06-04
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA000C3Q (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 95% 10mg $8 2026-05-25 Buy
aablocks AA000C3Q (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 95% 25mg $10 2026-05-25 Buy
aablocks AA000C3Q (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide ≥98% 50mg $10 2026-05-25 Buy
aablocks AA000C3Q (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 95% 100mg $15 2026-05-25 Buy
aablocks AA000C3Q (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide ≥98% 250mg $16 2026-05-25 Buy
aablocks AA000C3Q (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 95% 1g $30 2026-05-25 Buy
aablocks AA000C3Q (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 95% 5g $98 2026-05-25 Buy
aablocks AA000C3Q (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 98% 25g $363 2026-05-25 Buy
AccelPharmtech AT6629 entacapone 99.00% 1G $270 2026-05-21 Buy
Adipogen Life Sciences AG-CR1-3708-M025 Entacapone ≥98%(HPLC) 25mg $60 2026-05-06 Buy
Adipogen Life Sciences AG-CR1-3708-M005 Entacapone ≥98%(HPLC) 5mg $25 2026-05-06 Buy
AHH MT-50794 Entacapone 97% 0.1g $330 2026-05-26 Buy
AK Scientific J90011 Entacapone 95% 1g $495 2026-06-04 Buy
AK Scientific G843 Entacapone 98%(HPLC) 25g $518 2026-06-04 Buy
AK Scientific G843 Entacapone 98%(HPLC) 100mg $25 2026-06-04 Buy
AK Scientific G843 Entacapone 98%(HPLC) 250mg $30 2026-06-04 Buy
Next Last

Properties

Melting point :162-1630C
Boiling point :526.6±50.0 °C(Predicted)
Density :1.392±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
pka :pKa ~4.5(at 25℃)
form :powder
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChI :InChI=1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+
InChIKey :JRURYQJSLYLRLN-BJMVGYQFSA-N
SMILES :C(N(CC)CC)(=O)/C(/C#N)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1
CAS DataBase Reference :130929-57-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Catechol O-methyltransferase (COMT) is a key enzyme involved in the degradation of catecholamines including dopamine, epinephrine, and norepinephrine. COMPT metabolizes L-3,4-dihydroxyphenylalanine (L-DOPA) to 3-O-methyldopa (3-OMD), and then further to vanillactic acid, which is excreted in urine. Entacapone is a peripherally acting, selective and reversible COMT inhibitor with IC50 values of 150-300 nM in rat liver (Ki = 145 nM) and 10-20 nM in rat brain tissues. It was designed as an adjuvant to L-DOPA/dopa decarboxylase inhibitor treatment for Parkinson’s disease. Peripheral COMT inhibition with entacapone can decrease 3-OMD levels in the rat brain by 16-52% and prolong the bioavailability of L-DOPA in patients with Parkinson’s disease.

More related product prices

2809-21-4 Ethylene glycol diethyl ether Mefenpyr-diethyl Sodium 3-nitrobenzenesulphonate p-Nitrobenzoic acid Entecavir Entecavir hydrate Diethyl oxalate Diethyl malonate 3,5-DINITROCATECHOL 116313-85-0 CIS-ENTACAPONE Nitrobenzene 1,3-Dinitrobenzene Acrylamide Diethyl ether Entacapone Tolcapone

Related product price

Suppliers and manufacturers

Hunan Kaimir Biotechnology Co., Ltd. J & K SCIENTIFIC LTD. 3B Pharmachem (Wuhan) International Co.,Ltd. Chembest Research Laboratories Limited Beijing dtftchem Technology Co., Ltd. Jia Xing Isenchem Co.,Ltd Pure Chemistry Scientific Inc. Zhejiang Jianfeng Haizhou Pharmaceutical Co., Ltd. Adamas Reagent, Ltd. LGM Pharma