Entacapone
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- $5 - $1957.73
- Product name: Entacapone
- CAS: 130929-57-6
- MF: C14H15N3O5
- MW: 305.29
- EINECS:212-686-0
- MDL Number:MFCD00866580
- Synonyms:(E)-2-Cyano-3-(3，4-dihydroxy-5-nitrophenyl)-N，N-diethyl-2-pmpenamide;Entacapone (150 mg);(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enaMide;2-PropenaMide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-;Entacapone (isomer E);(E)-2-cyano-3-(5-(dihydroxyamino)-3,4-dioxocyclohexa-1,5-dienyl)-N,N-diethylacrylamide;ENTACAPONE;2-cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-n,n-diethyl-prop-2-enamide
40 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- y0001249
- 10mM(in 1mL DMSO)
- 10mg
- 5mg
- 50
- 10
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1G
- 5g
- 10g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3708-M005
- Product descriptionEntacapone ≥98%(HPLC)
- Packaging5mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ90011
- Product descriptionEntacapone
- Packaging100mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberG843
- Product descriptionEntacapone
- Packaging250mg
- Price$201
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA102154
- Product description(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide 95%
- Packaging50mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA102154
- Product description(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide 95%
- Packaging5g
- Price$107
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002552
- Product descriptionENTACAPONE 95.00%
- Packaging1G
- Price$1957.73
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4168
- Product descriptionEntacapone
- Packaging10mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4168
- Product descriptionEntacapone
- Packaging10mM(in 1mL DMSO)
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4168
- Product descriptionEntacapone
- Packaging100mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2442
- Product descriptionEntacapone
- Packaging25mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2442
- Product descriptionEntacapone
- Packaging100mg
- Price$129
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2442
- Product descriptionEntacapone
- Packaging1g
- Price$279
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2442
- Product descriptionEntacapone
- Packaging10g
- Price$875
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon3389
- Product descriptionEntacapone-OR611 98%
- Packaging10mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon3389
- Product descriptionEntacapone-OR611 98%
- Packaging50mg
- Price$165
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545948
- Product descriptionEntacapone >98%
- Packaging10mg
- Price$136
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3708-M005 | Entacapone ≥98%(HPLC) | 5mg | $25 | 2021-12-16 | Buy |
| AK Scientific | J90011 | Entacapone | 100mg | $75 | 2021-12-16 | Buy |
| AK Scientific | G843 | Entacapone | 250mg | $201 | 2021-12-16 | Buy |
| Ambeed | A102154 | (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide 95% | 50mg | $5 | 2021-12-16 | Buy |
| Ambeed | A102154 | (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide 95% | 5g | $107 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002552 | ENTACAPONE 95.00% | 1G | $1957.73 | 2021-12-16 | Buy |
| ApexBio Technology | A4168 | Entacapone | 10mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A4168 | Entacapone | 10mM(in 1mL DMSO) | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A4168 | Entacapone | 100mg | $150 | 2021-12-16 | Buy |
| AvaChem | 2442 | Entacapone | 25mg | $45 | 2021-12-16 | Buy |
| AvaChem | 2442 | Entacapone | 100mg | $129 | 2021-12-16 | Buy |
| AvaChem | 2442 | Entacapone | 1g | $279 | 2021-12-16 | Buy |
| AvaChem | 2442 | Entacapone | 10g | $875 | 2021-12-16 | Buy |
| Axon Medchem | Axon3389 | Entacapone-OR611 98% | 10mg | $55 | 2021-12-16 | Buy |
| Axon Medchem | Axon3389 | Entacapone-OR611 98% | 50mg | $165 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545948 | Entacapone >98% | 10mg | $136 | 2021-12-16 | Buy |
Properties
Melting point :162-1630C
Boiling point :526.6±50.0 °C(Predicted)
Density :1.392±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :pKa ~4.5(at 25℃)
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :JRURYQJSLYLRLN-BJMVGYQFSA-N
CAS DataBase Reference :130929-57-6(CAS DataBase Reference)
Boiling point :526.6±50.0 °C(Predicted)
Density :1.392±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :pKa ~4.5(at 25℃)
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :JRURYQJSLYLRLN-BJMVGYQFSA-N
CAS DataBase Reference :130929-57-6(CAS DataBase Reference)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Catechol O-methyltransferase (COMT) is a key enzyme involved in the degradation of catecholamines including dopamine, epinephrine, and norepinephrine. COMPT metabolizes L-3,4-dihydroxyphenylalanine (L-DOPA) to 3-O-methyldopa (3-OMD), and then further to vanillactic acid, which is excreted in urine. Entacapone is a peripherally acting, selective and reversible COMT inhibitor with IC50 values of 150-300 nM in rat liver (Ki = 145 nM) and 10-20 nM in rat brain tissues. It was designed as an adjuvant to L-DOPA/dopa decarboxylase inhibitor treatment for Parkinson’s disease. Peripheral COMT inhibition with entacapone can decrease 3-OMD levels in the rat brain by 16-52% and prolong the bioavailability of L-DOPA in patients with Parkinson’s disease.More related product prices
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