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ChemicalBook >> CAS DataBase List >> R-406

R-406

$13 - $5180
Product name: R-406
CAS: 841290-80-0
MF: C22H23FN6O5
MW: 470.45
EINECS:617-533-5
MDL Number:MFCD09970820
Synonyms:R-406;6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one ;6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one;6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;R406(free base);R-406 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one;R406 (free base), >=98%;R406 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

Price80 Properties Safety Information Description

80 prices

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Brand

aablocks
ACHEMBLOCK
Adipogen Life Sciences
American Custom Chemicals Corporation
ApexBio Technology
Arctom
Axon Medchem
Biorbyt Ltd
Cayman Chemical
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
Sigma-Aldrich
TRC
Usbiological

Package

25mg
10mM*1mLinDMSO(Solid+Solvent)
EvaluationSample
10mM(in1mLDMSO)
1unit
10mM*1mLinDMSO(Solution)
2x25mg
250.00mg
1.00g
5.00g
10mM*1mLinDMSO
1mg
2mg
5mg
10mg
100mg
500MG
50mg
250mg
5g
10mM(in 1mL DMSO)
1g

Manufactureraablocks
Product numberAA008GUJ
Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%
Packaging1mg
Price$13
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008GUJ
Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%
Packaging2mg
Price$16
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008GUJ
Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%
Packaging5mg
Price$19
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008GUJ
Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%
Packaging10mg
Price$23
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008GUJ
Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%
Packaging100mg
Price$34
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008GUJ
Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 95%
Packaging250mg
Price$40
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008GUJ
Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%
Packaging1g
Price$79
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008GUJ
Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 95%
Packaging5g
Price$318
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberA-624
Product description6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 95%
Packaging5G
Price$243
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberA-624
Product description6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 95%
Packaging1G
Price$72
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberA-624
Product description6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 95%
Packaging100MG
Price$36
Updated2026-05-27
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ManufacturerAdipogen Life Sciences
Product numberSYN-1121-M001
Product descriptionR406 ≥95%
Packaging1mg
Price$108
Updated2021-12-16
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ManufacturerAdipogen Life Sciences
Product numberSYN-1121-M001
Product descriptionR406 ≥95%
Packaging1mg
Price$108
Updated2026-05-06
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1121-M005
Product descriptionR406 ≥95%
Packaging5mg
Price$178
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberSYN-1121-M010
Product descriptionR406 ≥95%
Packaging10mg
Price$270
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberSYN-1121-M050
Product descriptionR406 ≥95%
Packaging50mg
Price$918
Updated2026-05-06
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA008GUJ	6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%	1mg	$13	2026-05-28	Buy
aablocks	AA008GUJ	6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%	2mg	$16	2026-05-28	Buy
aablocks	AA008GUJ	6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%	5mg	$19	2026-05-28	Buy
aablocks	AA008GUJ	6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%	10mg	$23	2026-05-28	Buy
aablocks	AA008GUJ	6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%	100mg	$34	2026-05-28	Buy
aablocks	AA008GUJ	6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 95%	250mg	$40	2026-05-28	Buy
aablocks	AA008GUJ	6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%	1g	$79	2026-05-28	Buy
aablocks	AA008GUJ	6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 95%	5g	$318	2026-05-28	Buy
ACHEMBLOCK	A-624	6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 95%	5G	$243	2026-05-27	Buy
ACHEMBLOCK	A-624	6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 95%	1G	$72	2026-05-27	Buy
ACHEMBLOCK	A-624	6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 95%	100MG	$36	2026-05-27	Buy
Adipogen Life Sciences	SYN-1121-M001	R406 ≥95%	1mg	$108	2021-12-16	Buy
Adipogen Life Sciences	SYN-1121-M001	R406 ≥95%	1mg	$108	2026-05-06	Buy
Adipogen Life Sciences	SYN-1121-M005	R406 ≥95%	5mg	$178	2026-05-06	Buy
Adipogen Life Sciences	SYN-1121-M010	R406 ≥95%	10mg	$270	2026-05-06	Buy
Adipogen Life Sciences	SYN-1121-M050	R406 ≥95%	50mg	$918	2026-05-06	Buy

Next Last

Properties

Melting point :182-184°C
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :10.63±0.40(Predicted)
color :Off-White to Light Grey
InChI :1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
InChIKey :NHHQJBCNYHBUSI-UHFFFAOYSA-N
SMILES :CC1(C(NC2=C(O1)C=CC(NC3=NC(NC4=CC(OC)=C(C(OC)=C4)OC)=NC=C3F)=N2)=O)C

Safety Information

Symbol(GHS):

Signal word:

Danger

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H301	Toxic if swalloed	Acute toxicity,oral	Category 3	Danger		P264, P270, P301+P310, P321, P330,P405, P501
H361	Suspected of damaging fertility or the unborn child	Reproductive toxicity	Category 2	Warning		P201, P202, P281, P308+P313, P405,P501

Precautionary statements:

P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P281	Use personal protective equipment as required.
P301+P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313	IF exposed or concerned: Get medical advice/attention.
P321	Specific treatment (see … on this label).
P330	Rinse mouth.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcεRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 μM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce immune complex-mediated inflammation. In cancers characterized by over-expression of Syk, R406 can prevent signaling downstream of Syk and induce apoptosis. R406 also inhibits Syk-dependent signaling through c-Jun N-terminal kinase in rheumatoid arthritis synoviocytes, suggesting a therapeutic intervention in this autoimmune disease.

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Suppliers and manufacturers

Hebei Yanxi Chemical Co., Ltd.

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R-406

Properties

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Description

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