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ChemicalBook >> CAS DataBase List >> RO3280

RO3280

$33 - $5358.4
Product name: RO3280
CAS: 1062243-51-9
MF: C27H35F2N7O3
MW: 543.61
EINECS:
MDL Number:MFCD22665717
Synonyms:RO3280;4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide;Ro5203280;Benzamide, 4-[(9-cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-;4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzam Ro 3280;4-[(9-CYCLOPENTYL-7,7-DIFLUORO-5-METHYL-6-OXO-6,7,8,9-TETRAHYDRO- 5H-PYRIMIDO[4,5-B][1,4]DIAZEPIN-2-YL)AMINO]-3-METHOXY-N-(1-METHYL -4-PIPERIDINYL)BENZAMIDE;4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazep;RO 3280; RO-3280

Price55 Properties Safety Information Description

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aablocks
ACHEMBLOCK
AK Scientific
ApexBio Technology
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Tocris
TRC
Usbiological

Package

2.5mg
100mg
50
250mg
1g
10
1000mg
10mM(in1mLDMSO)
1mg
2mg
5mg
50MG
10mg
25mg
10mM(in 1mL DMSO)

Manufactureraablocks
Product numberAA008TGL
Product description4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide 99%
Packaging1mg
Price$44
Updated2026-05-28
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Manufactureraablocks
Product numberAA008TGL
Product description4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide 99%
Packaging2mg
Price$53
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008TGL
Product description4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide 99%
Packaging5mg
Price$81
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008TGL
Product description4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide 99%
Packaging10mg
Price$117
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008TGL
Product description4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide 99%
Packaging25mg
Price$232
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberY227592
Product descriptionRo3280 97.00%
Packaging50MG
Price$475
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberY227592
Product descriptionRo3280 97.00%
Packaging10MG
Price$140
Updated2026-05-27
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ManufacturerAK Scientific
Product numberX5810
Product description4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Packaging10mg
Price$299
Updated2021-12-16
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ManufacturerApexBio Technology
Product numberA8681
Product descriptionRo3280
Packaging5mg
Price$168
Updated2021-12-16
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ManufacturerApexBio Technology
Product numberA8681
Product descriptionRo3280
Packaging5mg
Price$176
Updated2026-05-06
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ManufacturerApexBio Technology
Product numberA8681
Product descriptionRo3280
Packaging10mM(in 1mL DMSO)
Price$190
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA8681
Product descriptionRo3280
Packaging10mM(in1mLDMSO)
Price$190
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberA8681
Product descriptionRo3280
Packaging50mg
Price$931
Updated2021-12-16
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ManufacturerApexBio Technology
Product numberA8681
Product descriptionRo3280
Packaging50mg
Price$931
Updated2026-05-06
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ManufacturerBiorbyt Ltd
Product numberorb181119
Product descriptionRo3280 >98%
Packaging100mg
Price$1356.6
Updated2021-12-16
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ManufacturerBiorbyt Ltd
Product numberorb181119
Product descriptionRo3280 >98%
Packaging250mg
Price$2691.1
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA008TGL	4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide 99%	1mg	$44	2026-05-28	Buy
aablocks	AA008TGL	4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide 99%	2mg	$53	2026-05-28	Buy
aablocks	AA008TGL	4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide 99%	5mg	$81	2026-05-28	Buy
aablocks	AA008TGL	4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide 99%	10mg	$117	2026-05-28	Buy
aablocks	AA008TGL	4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide 99%	25mg	$232	2026-05-28	Buy
ACHEMBLOCK	Y227592	Ro3280 97.00%	50MG	$475	2026-05-27	Buy
ACHEMBLOCK	Y227592	Ro3280 97.00%	10MG	$140	2026-05-27	Buy
AK Scientific	X5810	4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide	10mg	$299	2021-12-16	Buy
ApexBio Technology	A8681	Ro3280	5mg	$168	2021-12-16	Buy
ApexBio Technology	A8681	Ro3280	5mg	$176	2026-05-06	Buy
ApexBio Technology	A8681	Ro3280	10mM(in 1mL DMSO)	$190	2021-12-16	Buy
ApexBio Technology	A8681	Ro3280	10mM(in1mLDMSO)	$190	2026-05-06	Buy
ApexBio Technology	A8681	Ro3280	50mg	$931	2021-12-16	Buy
ApexBio Technology	A8681	Ro3280	50mg	$931	2026-05-06	Buy
Biorbyt Ltd	orb181119	Ro3280 >98%	100mg	$1356.6	2021-12-16	Buy
Biorbyt Ltd	orb181119	Ro3280 >98%	250mg	$2691.1	2021-12-16	Buy

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Properties

storage temp. :Store at -20°C
solubility :≥27.2 mg/mL in DMSO; insoluble in H2O; ≥24.75 mg/mL in EtOH
form :solid
color :Off-white to yellow
InChIKey :DJNZZLZKAXGMMC-UHFFFAOYSA-N
SMILES :FC1(F)CN(C2CCCC2)C3=NC(NC4=CC=C(C(NC5CCN(C)CC5)=O)C=C4OC)=NC=C3N(C)C1=O

Safety Information

Symbol(GHS):

Signal word:

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

Precautionary statements:

Description

Ro3280 is a Polo-like kinase 1 (PLK1) inhibitor. Ro3280 shows strong antitumor activity in xenograft mouse models, has good selectivity against other kinases and has excellent in vitro cellular potency.

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RO3280

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