Trametinib
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- $28 - $4391.1
- Product name: Trametinib
- CAS: 871700-17-3
- MF: C26H23FIN5O4
- MW: 615.39
- EINECS:
- MDL Number:MFCD17215075
- Synonyms:N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide GSK-1120212;Trametinib (GSK1120212,JTP 74057);Trametinib, >=98%;Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-;N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-tri;N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide;TraMetinib;GSK-1120212(traMetinib,JTP-74057)
52 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- TRC
Package
- 1unit
- 1mg
- 5mg
- 2x5mg
- 10mg
- 25mg
- 50mg
- 2x25mg
- 100mg
- 200mg
- 250mg
- 500mg
- 10mM(in 1mL DMSO)
- 1g
- 2g
- 5G
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1170-M001
- Product descriptionGSK1120212 ≥95%
- Packaging1mg
- Price$86
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1170-M010
- Product descriptionGSK1120212 ≥95%
- Packaging10mg
- Price$221
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7454
- Product descriptionTrametinib
- Packaging25mg
- Price$81
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ53176
- Product descriptionTrametinib
- Packaging1g
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3018
- Product descriptionTrametinib(GSK1120212)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3018
- Product descriptionTrametinib(GSK1120212)
- Packaging10mM(in 1mL DMSO)
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60051
- Product descriptionTrametinib(GSK1120212) ≥98%
- Packaging10mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3376
- Product descriptionTrametinib
- Packaging5mg
- Price$29
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3376
- Product descriptionTrametinib
- Packaging10mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3376
- Product descriptionTrametinib
- Packaging25mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3376
- Product descriptionTrametinib
- Packaging100mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3376
- Product descriptionTrametinib
- Packaging1g
- Price$385
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1761
- Product descriptionGSK1120212-Trametinib|JTP74057 99%
- Packaging2x5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1761
- Product descriptionGSK1120212-Trametinib|JTP74057 99%
- Packaging2x25mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546250
- Product descriptionTrametinib >98%
- Packaging10mg
- Price$136
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb153631
- Product descriptionTrametinib >99% pure
- Packaging10mg
- Price$297.5
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1170-M001 | GSK1120212 ≥95% | 1mg | $86 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1170-M010 | GSK1120212 ≥95% | 10mg | $221 | 2021-12-16 | Buy |
| AK Scientific | X7454 | Trametinib | 25mg | $81 | 2021-12-16 | Buy |
| AK Scientific | J53176 | Trametinib | 1g | $450 | 2021-12-16 | Buy |
| ApexBio Technology | A3018 | Trametinib(GSK1120212) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A3018 | Trametinib(GSK1120212) | 10mM(in 1mL DMSO) | $55 | 2021-12-16 | Buy |
| Arctom | CFN60051 | Trametinib(GSK1120212) ≥98% | 10mg | $118 | 2021-12-16 | Buy |
| AvaChem | 3376 | Trametinib | 5mg | $29 | 2021-12-16 | Buy |
| AvaChem | 3376 | Trametinib | 10mg | $39 | 2021-12-16 | Buy |
| AvaChem | 3376 | Trametinib | 25mg | $49 | 2021-12-16 | Buy |
| AvaChem | 3376 | Trametinib | 100mg | $95 | 2021-12-16 | Buy |
| AvaChem | 3376 | Trametinib | 1g | $385 | 2021-12-16 | Buy |
| Axon Medchem | Axon1761 | GSK1120212-Trametinib|JTP74057 99% | 2x5mg | $110 | 2021-12-16 | Buy |
| Axon Medchem | Axon1761 | GSK1120212-Trametinib|JTP74057 99% | 2x25mg | $330 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546250 | Trametinib >98% | 10mg | $136 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb153631 | Trametinib >99% pure | 10mg | $297.5 | 2021-12-16 | Buy |
Properties
Melting point :300-301 °C
Density :1.74
storage temp. :-20°C
solubility :Soluble in DMSO (up to 20 mg/ml)
form :White solid.
pka :14.76±0.70(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Density :1.74
storage temp. :-20°C
solubility :Soluble in DMSO (up to 20 mg/ml)
form :White solid.
pka :14.76±0.70(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety Information
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Description
The dual specificity mitogen-activated protein kinase kinases (MEK) isoforms MEK1 and MEK2 function in a RAS/RAF/MEK/ERK signaling pathway to control cell growth, survival, and differentiation. Trametinib is a potent inhibitor of both MEK 1 and 2 that works in an ATP-noncompetitive fashion (IC50s = 0.7 and 0.9 nM, respectively). It shows specificity for MEK1/2 over a panel of more than 180 kinases, including B-Raf, c-Raf, and MEK5. Trametinib blocks dual phosphorylation of ERK1/2 and stops cell cycling in cancer cell lines, both in vitro and in multiple tumor models in mice. Trametinib, alone or in combination with other chemotherapeutic drugs, targets a subset of cancer cells that can be characterized by specific biomarkers, such as B-Raf, RAS, or CTNNB1 mutations.Related product price
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Suppliers and manufacturers
BIONNA MEDICINE CO.,LTD
Henan Tianfu Chemical Co.,Ltd.
Hangzhou FandaChem Co.,Ltd.
Nanjing ChemLin Chemical Industry Co., Ltd.
Nanjing Finetech Chemical Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Biochempartner
Hubei xin bonus chemical co. LTD
![N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide](https://img.chemicalbook.com/ProductImageEN/2018-12/small/fe498182-1055-4d7c-bbd5-8bbb37f80631.png){kind=small}
