Ranolazine-d5
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- $230 - $1871.1
- Product name: Ranolazine-d5
- CAS: 1092804-87-9
- MF: C24H28D5N3O4
- MW: 432.56732889
- EINECS:
- MDL Number:
- Synonyms:Ranolazine-d5;N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl-1,1,2,3,3-d5]-1-piperazineacetamide
5 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Cayman Chemical
Package
- 500μg
- 1mg
- 10MG
- ManufacturerAK Scientific
- Product number2996DC
- Product descriptionN-(2,6-Dimethylphenyl)-2-[4-[1,1,2,3,3-pentadeuterio-2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
- Packaging1mg
- Price$559
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberRDL0007103
- Product descriptionRANOLAZINE-D5 95.00%
- Packaging1MG
- Price$739.2
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberRDL0007103
- Product descriptionRANOLAZINE-D5 95.00%
- Packaging10MG
- Price$1871.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number25424
- Product descriptionRanolazine-d5 ≥99% deuterated forms (d1-d5)
- Packaging500μg
- Price$230
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25424
- Product descriptionRanolazine-d5 ≥99% deuterated forms (d1-d5)
- Packaging1mg
- Price$434
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2996DC | N-(2,6-Dimethylphenyl)-2-[4-[1,1,2,3,3-pentadeuterio-2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide | 1mg | $559 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | RDL0007103 | RANOLAZINE-D5 95.00% | 1MG | $739.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | RDL0007103 | RANOLAZINE-D5 95.00% | 10MG | $1871.1 | 2021-12-16 | Buy |
| Cayman Chemical | 25424 | Ranolazine-d5 ≥99% deuterated forms (d1-d5) | 500μg | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 25424 | Ranolazine-d5 ≥99% deuterated forms (d1-d5) | 1mg | $434 | 2024-03-01 | Buy |
Properties
storage temp. :Store at -20°C
solubility :Dichloromethane: Soluble; Methanol: Soluble
form :A solid
solubility :Dichloromethane: Soluble; Methanol: Soluble
form :A solid
Safety Information
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Description
Ranolazine-d5 is intended for use as an internal standard for the quantification of ranolazine by GC- or LC-MS. Ranolazine is a piperazine derivative with cardioprotective activity.1,2,3,4 It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively).1,2 Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively).2 In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits.3 Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .4More related product prices
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