Repotrectinib
|
- $8 - $1600
- Product name: Repotrectinib
- CAS: 1802220-02-5
- MF: C18H18FN5O2
- MW: 355.37
- EINECS:125-417-3
- MDL Number:MFCD31544350
- Synonyms:TPX-0005;TPX 0005;TPX0005;CS-2479;Repotrectinib(TPX-005);Repotrectinib,TPX-0005;1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)-;TPX-0005,Repotrectinib;TPX0005(Ropotrectinib);Ropotrectinib(TPX0005)
44 prices
Selected condition：
Brand
- aablocks
- AK Scientific
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
Package
- 2mg
- 250.00mg
- 1g
- 10mM*1mLinDMSO
- 50mg
- 1.00g
- 5.00g
- 10mM*1mLinDMSO(Solution)
- 1mg
- 5mg
- 10mg
- 250mg
- 25mg
- 100mg
- 10mM*1mLinDMSO(Solid+Solvent)
- Manufactureraablocks
- Product numberAA003ARB
- Product description1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99%
- Packaging1mg
- Price$8
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003ARB
- Product description1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99%
- Packaging5mg
- Price$11
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003ARB
- Product description1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- ≥98%
- Packaging10mg
- Price$17
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003ARB
- Product description1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99%
- Packaging25mg
- Price$19
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003ARB
- Product description1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99%
- Packaging100mg
- Price$38
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003ARB
- Product description1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99%
- Packaging250mg
- Price$61
- Updated2026-05-28
- Buy
- ManufacturerAK Scientific
- Product number3224EM
- Product descriptionRepotrectinib
- Packaging5mg
- Price$252
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3224EM
- Product descriptionRepotrectinib
- Packaging10mg
- Price$370
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3224EM
- Product descriptionRepotrectinib
- Packaging25mg
- Price$691
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4650
- Product descriptionRepotrectinib
- Packaging25mg
- Price$307
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4650
- Product descriptionRepotrectinib
- Packaging5mg
- Price$100
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4650
- Product descriptionRepotrectinib
- Packaging10mg
- Price$150
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-103022
- Product descriptionRepotrectinib 99.95%
- Packaging10mg
- Price$168
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-103022
- Product descriptionRepotrectinib 99.95%
- Packaging5mg
- Price$105
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-103022
- Product descriptionRepotrectinib 99.95%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$115
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-103022
- Product descriptionRepotrectinib 99.95%
- Packaging10mM*1mLinDMSO(Solution)
- Price$115
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA003ARB | 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99% | 1mg | $8 | 2026-05-28 | Buy |
| aablocks | AA003ARB | 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99% | 5mg | $11 | 2026-05-28 | Buy |
| aablocks | AA003ARB | 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- ≥98% | 10mg | $17 | 2026-05-28 | Buy |
| aablocks | AA003ARB | 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99% | 25mg | $19 | 2026-05-28 | Buy |
| aablocks | AA003ARB | 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99% | 100mg | $38 | 2026-05-28 | Buy |
| aablocks | AA003ARB | 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99% | 250mg | $61 | 2026-05-28 | Buy |
| AK Scientific | 3224EM | Repotrectinib | 5mg | $252 | 2021-12-16 | Buy |
| AK Scientific | 3224EM | Repotrectinib | 10mg | $370 | 2021-12-16 | Buy |
| AK Scientific | 3224EM | Repotrectinib | 25mg | $691 | 2021-12-16 | Buy |
| ApexBio Technology | A4650 | Repotrectinib | 25mg | $307 | 2026-05-06 | Buy |
| ApexBio Technology | A4650 | Repotrectinib | 5mg | $100 | 2026-05-06 | Buy |
| ApexBio Technology | A4650 | Repotrectinib | 10mg | $150 | 2026-05-06 | Buy |
| Arctom | HY-103022 | Repotrectinib 99.95% | 10mg | $168 | 2026-05-26 | Buy |
| Arctom | HY-103022 | Repotrectinib 99.95% | 5mg | $105 | 2026-05-26 | Buy |
| Arctom | HY-103022 | Repotrectinib 99.95% | 10mM*1mLinDMSO(Solid+Solvent) | $115 | 2026-05-26 | Buy |
| Arctom | HY-103022 | Repotrectinib 99.95% | 10mM*1mLinDMSO(Solution) | $115 | 2026-05-26 | Buy |
Properties
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:35.0(Max Conc. mg/mL);98.5(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);28.1(Max Conc. mM) form :A crystalline solid
pka :10.79±0.60(Predicted)
color :White to off-white
InChI :InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1
InChIKey :FIKPXCOQUIZNHB-WDEREUQCSA-N
SMILES :O1C2=CC=C(F)C=C2[C@@H](C)NC2C=CN3C(N=2)=C(C=N3)C(=O)NC[C@@H]1C
storage temp. :Store at -20°C
solubility :DMSO:35.0(Max Conc. mg/mL);98.5(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);28.1(Max Conc. mM) form :A crystalline solid
pka :10.79±0.60(Predicted)
color :White to off-white
InChI :InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1
InChIKey :FIKPXCOQUIZNHB-WDEREUQCSA-N
SMILES :O1C2=CC=C(F)C=C2[C@@H](C)NC2C=CN3C(N=2)=C(C=N3)C(=O)NC[C@@H]1C
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Ropotrectinib (TPX-0005; TP Therapeutics, San Diego, CA, USA) is a nextgeneration ROS1 inhibitor, a novel three-dimensional macrocyle with a much smaller size (MW <370) than current ROS1 inhibitors. It was specifically designed to overcome resistance mutations. Preclinical studies have shown activity against gatekeeper and solvent mutations, including G2032R, D2033N, L2026M, S1986F/Y, L1951R, and kinases involved in bypass signaling such as focal adhesion kinase, SRC proto-oncogene, and non-receptor tyrosine kinase [102, 103].Related product price
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Suppliers and manufacturers
Anqing Benro pharmachem Technology Co.,Ltd.
ShangHai Caerulum Pharma Discovery Co., Ltd.
Suzhou Ryan Pharmaceutical Technology Co., Ltd.
Shandong Dayou Pharmaceutical Research and Development Co., Ltd.
Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd
Dalian Meilun Biotech Co., Ltd.
Shanghai Hope Chem Co., Ltd.，
MedChemexpress LLC
TargetMol Chemicals Inc.
BEIJING EAGLE SKY PHARMATECH CO., LTD