Ribociclib
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- $28 - $666
- Product name: Ribociclib
- CAS: 1211441-98-3
- MF: C23H30N8O
- MW: 434.54
- EINECS:807-111-0
- MDL Number:MFCD27976795
- Synonyms:7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide LEE 011;LEE 011 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;LEE011, >=98%;7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE;LEE-011, Ribociclib;7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-;Ribociclib 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
26 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Tocris
- TRC
Package
- 1mg
- 50
- 500μg
- 5mg
- 2x5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 25 mg
- 50 mg
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1213-M100
- Product descriptionLEE011 ≥95%
- Packaging100mg
- Price$594
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2513AH
- Product descriptionRibociclib
- Packaging5mg
- Price$97
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8641
- Product descriptionLEE011
- Packaging50mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60093
- Product descriptionRibociclib(LEE011)
- Packaging10mg
- Price$188
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2273
- Product descriptionLEE011-Ribociclib 99%
- Packaging2x5mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR106414
- Product descriptionRibociclib
- Packaging25mg
- Price$87.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR106414
- Product descriptionRibociclib
- Packaging50mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR106414
- Product descriptionRibociclib
- Packaging100mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR106414
- Product descriptionRibociclib
- Packaging250mg
- Price$375
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR106414
- Product descriptionRibociclib
- Packaging500mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17666
- Product descriptionLEE011 ≥95%
- Packaging500μg
- Price$28
- Updated2023-01-06
- Buy
- ManufacturerCayman Chemical
- Product number17666
- Product descriptionLEE011 ≥95%
- Packaging5mg
- Price$40
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17666
- Product descriptionLEE011 ≥95%
- Packaging1mg
- Price$53
- Updated2023-01-06
- Buy
- ManufacturerCayman Chemical
- Product number17666
- Product descriptionLEE011 ≥95%
- Packaging10mg
- Price$68
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17666
- Product descriptionLEE011 ≥95%
- Packaging25 mg
- Price$90
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17666
- Product descriptionLEE011 ≥95%
- Packaging50 mg
- Price$140
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1213-M100 | LEE011 ≥95% | 100mg | $594 | 2021-12-16 | Buy |
| AK Scientific | 2513AH | Ribociclib | 5mg | $97 | 2021-12-16 | Buy |
| ApexBio Technology | A8641 | LEE011 | 50mg | $250 | 2021-12-16 | Buy |
| Arctom | CFN60093 | Ribociclib(LEE011) | 10mg | $188 | 2021-12-16 | Buy |
| Axon Medchem | Axon2273 | LEE011-Ribociclib 99% | 2x5mg | $132 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR106414 | Ribociclib | 25mg | $87.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR106414 | Ribociclib | 50mg | $150 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR106414 | Ribociclib | 100mg | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR106414 | Ribociclib | 250mg | $375 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR106414 | Ribociclib | 500mg | $600 | 2021-12-16 | Buy |
| Cayman Chemical | 17666 | LEE011 ≥95% | 500μg | $28 | 2023-01-06 | Buy |
| Cayman Chemical | 17666 | LEE011 ≥95% | 5mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 17666 | LEE011 ≥95% | 1mg | $53 | 2023-01-06 | Buy |
| Cayman Chemical | 17666 | LEE011 ≥95% | 10mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 17666 | LEE011 ≥95% | 25 mg | $90 | 2024-03-01 | Buy |
| Cayman Chemical | 17666 | LEE011 ≥95% | 50 mg | $140 | 2024-03-01 | Buy |
Properties
Boiling point :730.8±70.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
vapor pressure :0-0Pa at 20-25℃
storage temp. :-20°C
solubility :Soluble in DMSO (up to 10 mg/ml)
pka :8.67±0.10(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
LogP :-0.8-2.3 at 20℃ and pH4-11
Density :1.39±0.1 g/cm3(Predicted)
vapor pressure :0-0Pa at 20-25℃
storage temp. :-20°C
solubility :Soluble in DMSO (up to 10 mg/ml)
pka :8.67±0.10(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
LogP :-0.8-2.3 at 20℃ and pH4-11
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
LEE011 is a cyclin-dependent kinase (CDK) inhibitor that targets cyclin D1/CDK4 and cyclin D3/CDK6 at nanomolar concentrations. It inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G1-S phase transition, arresting the cell cycle in the G1 phase, suppressing DNA synthesis, and inhibiting cancer cell growth. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).More related product prices
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