S-EMCA
|
- $121 - $2520
- Product name: S-EMCA
- CAS: 1199796-29-6
- MF: C27H46O5
- MW: 450.65114
- EINECS:
- MDL Number:MFCD18837028
- Synonyms:6α-Ethyl-23(S)-Methylcholic acid;INT-777;S-EMCA;6alpha-Ethyl-23(S)-methylcholic acid;Cholane-23-carboxylic acid, 6-ethyl-3,7,12-trihydroxy-, (3α,5β,6α,7α,12α,23S)-;INT-777, S-EMCA;CS-1212;6a-Ethyl-23(S)-methylcholic acid
16 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Crysdot
- TRC
Package
- 500μg
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product number3740AH
- Product description6A-Ethyl-23(S)-methylcholicacid
- Packaging1mg
- Price$353
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4672
- Product descriptionINT-777
- Packaging2mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4672
- Product descriptionINT-777
- Packaging5mg
- Price$525
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4672
- Product descriptionINT-777
- Packaging10mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4672
- Product descriptionINT-777
- Packaging50mg
- Price$2250
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17678
- Product descriptionINT-777 ≥95%
- Packaging500μg
- Price$121
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17678
- Product descriptionINT-777 ≥95%
- Packaging1mg
- Price$230
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-3199
- Product descriptionINT-777 100.00%
- Packaging5mg
- Price$420
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3199
- Product descriptionINT-777 100.00%
- Packaging10mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3199
- Product descriptionINT-777 100.00%
- Packaging50mg
- Price$1800
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3199
- Product descriptionINT-777 100.00%
- Packaging100mg
- Price$2520
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004321
- Product descriptionINT-777 98+%
- Packaging5mg
- Price$245
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004321
- Product descriptionINT-777 98+%
- Packaging10mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004321
- Product descriptionINT-777 98+%
- Packaging50mg
- Price$1050
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004321
- Product descriptionINT-777 98+%
- Packaging100mg
- Price$1470
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberI666630
- Product description6α-Ethyl-23(S)-methylcholicAcid
- Packaging25mg
- Price$2035
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3740AH | 6A-Ethyl-23(S)-methylcholicacid | 1mg | $353 | 2021-12-16 | Buy |
| ApexBio Technology | B4672 | INT-777 | 2mg | $350 | 2021-12-16 | Buy |
| ApexBio Technology | B4672 | INT-777 | 5mg | $525 | 2021-12-16 | Buy |
| ApexBio Technology | B4672 | INT-777 | 10mg | $750 | 2021-12-16 | Buy |
| ApexBio Technology | B4672 | INT-777 | 50mg | $2250 | 2021-12-16 | Buy |
| Cayman Chemical | 17678 | INT-777 ≥95% | 500μg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 17678 | INT-777 ≥95% | 1mg | $230 | 2024-03-01 | Buy |
| ChemScene | CS-3199 | INT-777 100.00% | 5mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-3199 | INT-777 100.00% | 10mg | $600 | 2021-12-16 | Buy |
| ChemScene | CS-3199 | INT-777 100.00% | 50mg | $1800 | 2021-12-16 | Buy |
| ChemScene | CS-3199 | INT-777 100.00% | 100mg | $2520 | 2021-12-16 | Buy |
| Crysdot | CD31004321 | INT-777 98+% | 5mg | $245 | 2021-12-16 | Buy |
| Crysdot | CD31004321 | INT-777 98+% | 10mg | $350 | 2021-12-16 | Buy |
| Crysdot | CD31004321 | INT-777 98+% | 50mg | $1050 | 2021-12-16 | Buy |
| Crysdot | CD31004321 | INT-777 98+% | 100mg | $1470 | 2021-12-16 | Buy |
| TRC | I666630 | 6α-Ethyl-23(S)-methylcholicAcid | 25mg | $2035 | 2021-12-16 | Buy |
Properties
Melting point :150-152℃
Boiling point :602.8±55.0 °C(Predicted)
Density :1.128±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF:30.0(Max Conc. mg/mL);66.57(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.11(Max Conc. mM)
DMSO:25.5(Max Conc. mg/mL);56.58(Max Conc. mM)
Ethanol:37.5(Max Conc. mg/mL);83.21(Max Conc. mM) pka :4.80±0.21(Predicted)
form :Powder
color :White to yellow
Boiling point :602.8±55.0 °C(Predicted)
Density :1.128±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF:30.0(Max Conc. mg/mL);66.57(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.11(Max Conc. mM)
DMSO:25.5(Max Conc. mg/mL);56.58(Max Conc. mM)
Ethanol:37.5(Max Conc. mg/mL);83.21(Max Conc. mM) pka :4.80±0.21(Predicted)
form :Powder
color :White to yellow
Safety Information
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Description
TGR5 is a transmembrane G protein-coupled receptor that is activated by bile acid. INT-777 is a semisynthetic bile acid that acts as an agonist of TGR5 (EC50 = 0.82 μM). It is active in vivo, stimulating the secretion of glucagon-like peptide-1 (GLP-1) in mice when given orally (30 mg/kg) after a glucose challenge, particularly when given with a dipeptidyl-peptidase-4 inhibitor. INT-777 increases energy expenditure and reduces hepatic steatosis and adiposity in mice subjected to diet-induced obesity. It also stimulates insulin secretion in pancreatic β cells, reduces inflammation and inhibits atherosclerosis in mice, and promotes chloride secretion through cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cells.Suppliers and manufacturers
China National Standard Pharmaceutical Corporation Limited
Amadis Chemical Company Limited
Guangzhou Brand-new Changshi Pharmaceutical Biotechnology Co., Ltd
Haoyuan Chemexpress Co., Ltd.
MedChemexpress LLC
ShangHai Caerulum Pharma Discovery Co., Ltd.
LETOPHARM LIMITED
Shanghai Lollane Biological Technology Co.,Ltd.
