SAfit2
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- $75 - $2085
- Product name: SAfit2
- CAS: 1643125-33-0
- MF: C46H62N2O10
- MW: 802.99
- EINECS:
- MDL Number:MFCD31619236
- Synonyms:SAfit2;2-Piperidinecarboxylic acid, 1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]-, (1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl ester, (2S)-;(R)-3-(3,4-Dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxylate;(1R)-3-(3,4-dimethoxyphenyl)-1-{3-[2-(morpholin-4-yl)ethoxy]phenyl}propyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate;SAFit2, 10 mM in DMSO;(S)-(R)-3-(3,4-Dimethoxyphenyl)-1-[3-(2-morpholinoethoxy)phenyl]propyl 1-[(S)-2-Cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate
27 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Arctom
- Cayman Chemical
- ChemScene
- TRC
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 500μg
- 10mM*1mLinDMSO(Solution)
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100MG
- Manufactureraablocks
- Product numberAA01EO7P
- Product descriptionSAfit2
- Packaging1mg
- Price$75
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EO7P
- Product descriptionSAfit2
- Packaging2mg
- Price$95
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EO7P
- Product descriptionSAfit2
- Packaging5mg
- Price$132
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EO7P
- Product descriptionSAfit2
- Packaging10mg
- Price$178
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EO7P
- Product descriptionSAfit2
- Packaging25mg
- Price$292
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EO7P
- Product descriptionSAfit2
- Packaging50mg
- Price$487
- Updated2026-05-30
- Buy
- ManufacturerACHEMBLOCK
- Product numberY226839
- Product descriptionSAFit2 97.00%
- Packaging10MG
- Price$235
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY226839
- Product descriptionSAFit2 97.00%
- Packaging25MG
- Price$405
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY226839
- Product descriptionSAFit2 97.00%
- Packaging100MG
- Price$960
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number5023EA
- Product descriptionSAFit2
- Packaging1mg
- Price$353
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-102080
- Product descriptionSAFit2 99.24%
- Packaging100mg
- Price$922
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-102080
- Product descriptionSAFit2 99.24%
- Packaging25mg
- Price$466
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-102080
- Product descriptionSAFit2 99.24%
- Packaging5mg
- Price$181
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-102080
- Product descriptionSAFit2 99.24%
- Packaging50mg
- Price$656
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-102080
- Product descriptionSAFit2 99.24%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$304
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-102080
- Product descriptionSAFit2 99.24%
- Packaging10mM*1mLinDMSO(Solution)
- Price$320
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01EO7P | SAfit2 | 1mg | $75 | 2026-05-30 | Buy |
| aablocks | AA01EO7P | SAfit2 | 2mg | $95 | 2026-05-30 | Buy |
| aablocks | AA01EO7P | SAfit2 | 5mg | $132 | 2026-05-30 | Buy |
| aablocks | AA01EO7P | SAfit2 | 10mg | $178 | 2026-05-30 | Buy |
| aablocks | AA01EO7P | SAfit2 | 25mg | $292 | 2026-05-30 | Buy |
| aablocks | AA01EO7P | SAfit2 | 50mg | $487 | 2026-05-30 | Buy |
| ACHEMBLOCK | Y226839 | SAFit2 97.00% | 10MG | $235 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y226839 | SAFit2 97.00% | 25MG | $405 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y226839 | SAFit2 97.00% | 100MG | $960 | 2026-05-27 | Buy |
| AK Scientific | 5023EA | SAFit2 | 1mg | $353 | 2021-12-16 | Buy |
| Arctom | HY-102080 | SAFit2 99.24% | 100mg | $922 | 2026-05-26 | Buy |
| Arctom | HY-102080 | SAFit2 99.24% | 25mg | $466 | 2026-05-26 | Buy |
| Arctom | HY-102080 | SAFit2 99.24% | 5mg | $181 | 2026-05-26 | Buy |
| Arctom | HY-102080 | SAFit2 99.24% | 50mg | $656 | 2026-05-26 | Buy |
| Arctom | HY-102080 | SAFit2 99.24% | 10mM*1mLinDMSO(Solid+Solvent) | $304 | 2026-05-26 | Buy |
| Arctom | HY-102080 | SAFit2 99.24% | 10mM*1mLinDMSO(Solution) | $320 | 2026-05-26 | Buy |
Properties
Boiling point :877.0±65.0 °C(Predicted)
Density :1.168±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form :A crystalline solid
pka :6.43±0.10(Predicted)
color :Off-white to pink
InChIKey :ZDBWLRLGUBSLPG-FDHYQTMZSA-N
SMILES :N1(C([C@@H](C2CCCCC2)C2=CC(OC)=C(OC)C(OC)=C2)=O)CCCC[C@H]1C(O[C@@H](C1=CC=CC(OCCN2CCOCC2)=C1)CCC1=CC=C(OC)C(OC)=C1)=O
Density :1.168±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form :A crystalline solid
pka :6.43±0.10(Predicted)
color :Off-white to pink
InChIKey :ZDBWLRLGUBSLPG-FDHYQTMZSA-N
SMILES :N1(C([C@@H](C2CCCCC2)C2=CC(OC)=C(OC)C(OC)=C2)=O)CCCC[C@H]1C(O[C@@H](C1=CC=CC(OCCN2CCOCC2)=C1)CCC1=CC=C(OC)C(OC)=C1)=O
Safety Information
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Description
SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51; Ki = 6 nM). It is highly selective for FKBP51 over FKBP52 (Ki = >50,000 nM) and has increased brain permeability in comparison to SAfit1. SAfit2 (20 mg/kg) enhances HPA axis suppression in mice by decreasing plasma corticosterone levels to a greater extent than in control mice following dexamethasone administration. It also does not increase plasma corticosterone levels as high as in control mice following subsequent administration of corticotropin-releasing factor (CRF; ). It decreases the time spent immobile in the forced swim test and increases the time spent in the open arms of the elevated plus maze, indicating antidepressant-like and anxiolytic-like activity, respectfully.Suppliers and manufacturers
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Jilin Chinese Academy of Sciences-yanshen Technology
ShangHai Caerulum Pharma Discovery Co., Ltd.
Shanghai Lollane Biological Technology Co.,Ltd.
Shanghai EFE Biological Technology Co., Ltd.
Shanghai Han-Xiang Chemical Co., Ltd.
Fan De(Beijing) Biotechnology Co., Ltd.
Henan Alpha Chemical Co., Ltd.
Jilin Province Woda Biotechnology Co., Ltd.
