SR8278
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- $15 - $2050
- Product name: SR8278
- CAS: 1254944-66-5
- MF: C18H19NO3S2
- MW: 361.48
- EINECS:
- MDL Number:MFCD18782736
- Synonyms:SR8278;1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester;UIEBLUZPSFAFOC-UHFFFAOYSA-N;SR8278;SR-8278;SR 8278;ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate;Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate;3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-, ethyl ester;Duchenne muscular dystrophy,inhibit,metabolism,biological rhythm,Alzheimer's disease,SR-8278,SR8278,neurosurgery,Inhibitor,REV-ERBα,SR 8278,REV-ERB
48 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 10mM*1mLinDMSO
- 10mg
- 50
- 25mg
- 50mg
- 100MG
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA009E3V
- Product descriptionEthyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate 98%
- Packaging1mg
- Price$15
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009E3V
- Product descriptionEthyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate 98%
- Packaging5mg
- Price$31
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009E3V
- Product descriptionEthyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate 98%
- Packaging10mg
- Price$44
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009E3V
- Product descriptionEthyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate 98%
- Packaging25mg
- Price$75
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009E3V
- Product descriptionEthyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate 98%
- Packaging50mg
- Price$125
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberU127640
- Product descriptionSR8278 98%
- Packaging25MG
- Price$100
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU127640
- Product descriptionSR8278 98%
- Packaging100MG
- Price$305
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number6895DK
- Product descriptionCID53393127
- Packaging1mg
- Price$147
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0014157
- Product descriptionSR-8278 95.00%
- Packaging10MG
- Price$216.3
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5606
- Product descriptionSR 8278
- Packaging10mg
- Price$275
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5606
- Product descriptionSR 8278
- Packaging25mg
- Price$606
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5606
- Product descriptionSR 8278
- Packaging5mg
- Price$148
- Updated2026-05-06
- Buy
- ManufacturerAvaChem
- Product number6809
- Product descriptionSR-8278 98%
- Packaging5mg
- Price$78
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number6809
- Product descriptionSR-8278 98%
- Packaging25mg
- Price$312
- Updated2026-05-22
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1940957
- Product descriptionSR8278 >98%(HPLC)
- Packaging50mg
- Price$570
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1940957
- Product descriptionSR8278 >98%(HPLC)
- Packaging10mg
- Price$260
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009E3V | Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate 98% | 1mg | $15 | 2026-05-28 | Buy |
| aablocks | AA009E3V | Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate 98% | 5mg | $31 | 2026-05-28 | Buy |
| aablocks | AA009E3V | Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate 98% | 10mg | $44 | 2026-05-28 | Buy |
| aablocks | AA009E3V | Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate 98% | 25mg | $75 | 2026-05-28 | Buy |
| aablocks | AA009E3V | Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate 98% | 50mg | $125 | 2026-05-28 | Buy |
| ACHEMBLOCK | U127640 | SR8278 98% | 25MG | $100 | 2026-05-27 | Buy |
| ACHEMBLOCK | U127640 | SR8278 98% | 100MG | $305 | 2026-05-27 | Buy |
| AK Scientific | 6895DK | CID53393127 | 1mg | $147 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014157 | SR-8278 95.00% | 10MG | $216.3 | 2021-12-16 | Buy |
| ApexBio Technology | B5606 | SR 8278 | 10mg | $275 | 2026-05-06 | Buy |
| ApexBio Technology | B5606 | SR 8278 | 25mg | $606 | 2026-05-06 | Buy |
| ApexBio Technology | B5606 | SR 8278 | 5mg | $148 | 2026-05-06 | Buy |
| AvaChem | 6809 | SR-8278 98% | 5mg | $78 | 2026-05-22 | Buy |
| AvaChem | 6809 | SR-8278 98% | 25mg | $312 | 2026-05-22 | Buy |
| Biorbyt Ltd | orb1940957 | SR8278 >98%(HPLC) | 50mg | $570 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1940957 | SR8278 >98%(HPLC) | 10mg | $260 | 2026-05-06 | Buy |
Properties
Melting point :52-55°C
Boiling point :535.7±50.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥30mg/mL
pka :-3.20±0.40(Predicted)
form :film
color :white to tan
InChI :1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3
InChIKey :UIEBLUZPSFAFOC-UHFFFAOYSA-N
SMILES :CCOC(=O)C1Cc2ccccc2CN1C(=O)c3ccc(SC)s3
Boiling point :535.7±50.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥30mg/mL
pka :-3.20±0.40(Predicted)
form :film
color :white to tan
InChI :1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3
InChIKey :UIEBLUZPSFAFOC-UHFFFAOYSA-N
SMILES :CCOC(=O)C1Cc2ccccc2CN1C(=O)c3ccc(SC)s3
Safety Information
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Description
REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBα (EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112 . Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells.More related product prices
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