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ChemicalBook >> CAS DataBase List >> Sitagliptin

Sitagliptin

Sitagliptin price.
  • $8 - $1504.5
  • Product name: Sitagliptin
  • CAS: 486460-32-6
  • MF: C16H15F6N5O
  • MW: 407.31
  • EINECS:690-730-1
  • MDL Number:MFCD09838015
  • Synonyms:Sitagliptin;(3R)-3-AMino-1-[3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,2,4-riazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-rifluorophenyl) butan-1-one;Sitagliptin-D4 HCL;Hsdb 7516;C53323300;Metformin / sitagliptin;Metformin hydrochloride mixture with sitagliptin phosphate;Metformin mixture with sitagliptin
Price29 Properties Safety Information Description
29 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • ChemScene
  • DC Chemicals
  • Labseeker
  • TRC
Package
  • 5MG
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • 2g
  • 5g
  • 10g
  • 25g
  • 50g
  • 1kg
  • ManufacturerAK Scientific
  • Product numberX4663
  • Product descriptionSitagliptin
  • Packaging100mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ96214
  • Product descriptionSitagliptin
  • Packaging10g
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA127061
  • Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
  • Packaging100mg
  • Price$8
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA127061
  • Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
  • Packaging250mg
  • Price$13
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA127061
  • Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
  • Packaging1g
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA127061
  • Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
  • Packaging5g
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA127061
  • Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
  • Packaging10g
  • Price$158
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA127061
  • Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
  • Packaging25g
  • Price$247
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0007146
  • Product descriptionSITAGLIPTIN-D4 95.00%
  • Packaging5MG
  • Price$497.41
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2201B
  • Product descriptionSitagliptin
  • Packaging100mg
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2201B
  • Product descriptionSitagliptin
  • Packaging1g
  • Price$149
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2201B
  • Product descriptionSitagliptin
  • Packaging10g
  • Price$490
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon3251
  • Product descriptionSitagliptin 100%
  • Packaging50mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146262
  • Product descriptionSitagliptin (Metformin,MK-0431) >98%
  • Packaging100mg
  • Price$510
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146262
  • Product descriptionSitagliptin (Metformin,MK-0431) >98%
  • Packaging250mg
  • Price$765
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146262
  • Product descriptionSitagliptin (Metformin,MK-0431) >98%
  • Packaging1g
  • Price$1504.5
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X4663 Sitagliptin 100mg $95 2021-12-16 Buy
AK Scientific J96214 Sitagliptin 10g $160 2021-12-16 Buy
Ambeed A127061 (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+% 100mg $8 2021-12-16 Buy
Ambeed A127061 (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+% 250mg $13 2021-12-16 Buy
Ambeed A127061 (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+% 1g $33 2021-12-16 Buy
Ambeed A127061 (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+% 5g $99 2021-12-16 Buy
Ambeed A127061 (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+% 10g $158 2021-12-16 Buy
Ambeed A127061 (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+% 25g $247 2021-12-16 Buy
American Custom Chemicals Corporation RDL0007146 SITAGLIPTIN-D4 95.00% 5MG $497.41 2021-12-16 Buy
AvaChem 2201B Sitagliptin 100mg $39 2021-12-16 Buy
AvaChem 2201B Sitagliptin 1g $149 2021-12-16 Buy
AvaChem 2201B Sitagliptin 10g $490 2021-12-16 Buy
Axon Medchem Axon3251 Sitagliptin 100% 50mg $55 2021-12-16 Buy
Biorbyt Ltd orb146262 Sitagliptin (Metformin,MK-0431) >98% 100mg $510 2021-12-16 Buy
Biorbyt Ltd orb146262 Sitagliptin (Metformin,MK-0431) >98% 250mg $765 2021-12-16 Buy
Biorbyt Ltd orb146262 Sitagliptin (Metformin,MK-0431) >98% 1g $1504.5 2021-12-16 Buy
Next Last

Properties

Melting point :114.1-115.7 °C
Boiling point :529.9±60.0 °C(Predicted)
Density :1.61±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : ≥ 50 mg/mL (122.76 mM)
pka :7.20±0.10(Predicted)
InChI :InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
InChIKey :MFFMDFFZMYYVKS-SECBINFHSA-N
SMILES :C(N1CCN2C(C(F)(F)F)=NN=C2C1)(=O)C[C@H](N)CC1=CC(F)=C(F)C=C1F
CAS DataBase Reference :486460-32-6(CAS DataBase Reference)
EPA Substance Registry System :1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)- (486460-32-6)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is a first-in-class oral drug launched for the treatment of type 2 diabetes. It acts by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. Incretin hormones, including glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. When blood glucose concentrations are normal or elevated,GLP-1 and GIP increase the synthesis and release of insulin from pancreatic b cells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic αcells, which leads to reduced hepatic glucose production.

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Suppliers and manufacturers

Changzhou Ruiming Pharmaceutical Co., LTD
Sitagliptin
$0.00 /25KG
Sitagliptin CAS:486460-32-6
Anhui Ruihan Technology Co., Ltd
Sitagliptin
$30.00 /1kg
Sitagliptin CAS:486460-32-6
Hebei Yanxi Chemical Co., Ltd.
Sitagliptin
$50.00 /1kg
Sitagliptin CAS:486460-32-6
Shanghai UCHEM Inc.
Sitagliptin
$46.00 /1g
Sitagliptin CAS:486460-32-6
Sinoway Industrial co., ltd.
Sitagliptin
$85.00 /100Kg/Bag
Sitagliptin CAS:486460-32-6
Chongqing Zhihe Biopharmaceutical Co., Ltd.
Sitagliptin
$0.00 /1kg
Sitagliptin CAS:486460-32-6
Henan Fengda Chemical Co., Ltd
Sitagliptin
$1.00 /100kg
Sitagliptin CAS:486460-32-6
Hebei Zhuanglai Chemical Trading Co.,Ltd
Sitagliptin
$100.00 /1kg
Sitagliptin CAS:486460-32-6
Capot Chemical Co.,Ltd.
Hi-Tech Chemistry Corp