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ChemicalBook >> CAS DataBase List >> Sitagliptin

Sitagliptin

$8 - $1663.75
Product name: Sitagliptin
CAS: 486460-32-6
MF: C16H15F6N5O
MW: 407.31
EINECS:690-730-1
MDL Number:MFCD09838015
Synonyms:Sitagliptin;(3R)-3-AMino-1-[3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,2,4-riazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-rifluorophenyl) butan-1-one;Sitagliptin-D4 HCL;Hsdb 7516;C53323300;Metformin / sitagliptin;Metformin hydrochloride mixture with sitagliptin phosphate;Metformin mixture with sitagliptin

Price59 Properties Safety Information Description

59 prices

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Brand

aablocks
ACHEMBLOCK
AK Scientific
Ambeed
American Custom Chemicals Corporation
Arctom
AvaChem
Axon Medchem
Biorbyt Ltd
Biosynth
ChemScene
DC Chemicals
Labseeker
Sigma-Aldrich
TCI Chemical
TRC
Usbiological

Package

10mM*1mLinDMSO(Solution)
10mM*1mLinDMSO(Solid+Solvent)
25mg
10mM(1mLinDMSO)
5MG
50mg
100mg
200mg
250mg
500mg
1G
2g
5g
0.01kg
10g
0.025kg
25g
0.05kg
50g
0.1kg
0.25kg
500g
1kg
10 mg
50 mg

Manufactureraablocks
Product numberAA00I8Q3
Product description(3R)-3-amino-1-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one ≥97%
Packaging100mg
Price$11
Updated2026-05-29
Buy

Manufactureraablocks
Product numberAA00I8Q3
Product description(3R)-3-amino-1-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98%
Packaging5g
Price$16
Updated2026-05-29
Buy

Manufactureraablocks
Product numberAA00I8Q3
Product description(3R)-3-amino-1-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98%
Packaging10g
Price$29
Updated2026-05-29
Buy

Manufactureraablocks
Product numberAA00I8Q3
Product description(3R)-3-amino-1-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98%
Packaging25g
Price$53
Updated2026-05-29
Buy

ManufacturerACHEMBLOCK
Product numberG-6373
Product descriptionSitagliptin 98%
Packaging5G
Price$56
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberG-6373
Product descriptionSitagliptin 98%
Packaging1G
Price$20
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product numberX4663
Product descriptionSitagliptin
Packaging100mg
Price$95
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product numberJ96214
Product descriptionSitagliptin
Packaging10g
Price$160
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA127061
Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
Packaging10g
Price$158
Updated2021-12-16
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ManufacturerAmbeed
Product numberA127061
Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
Packaging25g
Price$247
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA127061
Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
Packaging5g
Price$99
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA127061
Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
Packaging100mg
Price$8
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA127061
Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
Packaging250mg
Price$13
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA127061
Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
Packaging1g
Price$33
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberRDL0007146
Product descriptionSITAGLIPTIN-D4 95.00%
Packaging5MG
Price$497.41
Updated2021-12-16
Buy

ManufacturerArctom
Product numberSLK-S5079
Product descriptionSitagliptin 99.91%
Packaging1g
Price$922
Updated2026-05-26
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA00I8Q3	(3R)-3-amino-1-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one ≥97%	100mg	$11	2026-05-29	Buy
aablocks	AA00I8Q3	(3R)-3-amino-1-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98%	5g	$16	2026-05-29	Buy
aablocks	AA00I8Q3	(3R)-3-amino-1-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98%	10g	$29	2026-05-29	Buy
aablocks	AA00I8Q3	(3R)-3-amino-1-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98%	25g	$53	2026-05-29	Buy
ACHEMBLOCK	G-6373	Sitagliptin 98%	5G	$56	2026-05-27	Buy
ACHEMBLOCK	G-6373	Sitagliptin 98%	1G	$20	2026-05-27	Buy
AK Scientific	X4663	Sitagliptin	100mg	$95	2021-12-16	Buy
AK Scientific	J96214	Sitagliptin	10g	$160	2021-12-16	Buy
Ambeed	A127061	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%	10g	$158	2021-12-16	Buy
Ambeed	A127061	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%	25g	$247	2021-12-16	Buy
Ambeed	A127061	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%	5g	$99	2021-12-16	Buy
Ambeed	A127061	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%	100mg	$8	2021-12-16	Buy
Ambeed	A127061	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%	250mg	$13	2021-12-16	Buy
Ambeed	A127061	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%	1g	$33	2021-12-16	Buy
American Custom Chemicals Corporation	RDL0007146	SITAGLIPTIN-D4 95.00%	5MG	$497.41	2021-12-16	Buy
Arctom	SLK-S5079	Sitagliptin 99.91%	1g	$922	2026-05-26	Buy

Next Last

Properties

Melting point :114.1-115.7 °C
Boiling point :529.9±60.0 °C(Predicted)
Density :1.61±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : ≥ 50 mg/mL (122.76 mM)
pka :7.20±0.10(Predicted)
form :Solid
color :White to off-white
optical activity :-25.4620° (C=0.4167 g/100ml, CHCL3, 20°C, 589nm)
InChI :InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
InChIKey :MFFMDFFZMYYVKS-SECBINFHSA-N
SMILES :C(N1CCN2C(C(F)(F)F)=NN=C2C1)(=O)C[C@H](N)CC1=CC(F)=C(F)C=C1F
CAS DataBase Reference :486460-32-6(CAS DataBase Reference)
EPA Substance Registry System :1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)- (486460-32-6)

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is a first-in-class oral drug launched for the treatment of type 2 diabetes. It acts by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. Incretin hormones, including glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. When blood glucose concentrations are normal or elevated,GLP-1 and GIP increase the synthesis and release of insulin from pancreatic b cells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic αcells, which leads to reduced hepatic glucose production.

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Suppliers and manufacturers

AnHui HaiKang Pharmaceutical Co., Ltd. Hunan Furui Biopharma Technology Co., Ltd. ChemFuture PharmaTech (Jiangsu) Ltd Chembest Research Laboratories Limited Beijing HwrkChemical Technology Co., Ltd Capot Chemical Co., Ltd Beijing Ouhe Technology Co., Ltd Shanghai Scientia Pharmaceutical Technology Co., Ltd. JinYan Chemicals(ShangHai) Co.,Ltd. LGM Pharma

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Sitagliptin

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