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ChemicalBook >> CAS DataBase List >> Sitagliptin

Sitagliptin

$8 - $1504.5
Product name: Sitagliptin
CAS: 486460-32-6
MF: C16H15F6N5O
MW: 407.31
EINECS:690-730-1
MDL Number:MFCD09838015
Synonyms:Sitagliptin;(3R)-3-AMino-1-[3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,2,4-riazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-rifluorophenyl) butan-1-one;Sitagliptin-D4 HCL;Hsdb 7516;C53323300;Metformin / sitagliptin;Metformin hydrochloride mixture with sitagliptin phosphate;Metformin mixture with sitagliptin

Price51 Properties Safety Information Description

51 prices

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Brand

AK Scientific
Ambeed
American Custom Chemicals Corporation
Arctom
AvaChem
Axon Medchem
Biorbyt Ltd
Biosynth
ChemScene
DC Chemicals
Labseeker
Sigma-Aldrich
TCI Chemical
TRC

Package

200mg
10mM*1mLinDMSO(Solution)
100mg
10mM(1mLinDMSO)
5MG
25mg
50mg
10mM*1mLinDMSO(Solid+Solvent)
250mg
500mg
1g
2g
5g
10g
25g
50g
500g
1kg
10 mg
50 mg

ManufacturerAK Scientific
Product numberX4663
Product descriptionSitagliptin
Packaging100mg
Price$95
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product numberJ96214
Product descriptionSitagliptin
Packaging10g
Price$160
Updated2021-12-16
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ManufacturerAmbeed
Product numberA127061
Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
Packaging10g
Price$158
Updated2021-12-16
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ManufacturerAmbeed
Product numberA127061
Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
Packaging25g
Price$247
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA127061
Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
Packaging5g
Price$99
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA127061
Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
Packaging100mg
Price$8
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA127061
Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
Packaging250mg
Price$13
Updated2021-12-16
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ManufacturerAmbeed
Product numberA127061
Product description(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%
Packaging1g
Price$33
Updated2021-12-16
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ManufacturerAmerican Custom Chemicals Corporation
Product numberRDL0007146
Product descriptionSITAGLIPTIN-D4 95.00%
Packaging5MG
Price$497.41
Updated2021-12-16
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ManufacturerArctom
Product numberSLK-S5079
Product descriptionSitagliptin 99.91%
Packaging1g
Price$922
Updated2026-05-26
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ManufacturerArctom
Product numberHY-13749
Product descriptionSitagliptin 99.94%
Packaging100mg
Price$57
Updated2026-05-26
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ManufacturerArctom
Product numberHY-13749
Product descriptionSitagliptin 99.94%
Packaging10mM*1mLinDMSO(Solid+Solvent)
Price$63
Updated2026-05-26
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ManufacturerArctom
Product numberHY-13749
Product descriptionSitagliptin 99.94%
Packaging10mM*1mLinDMSO(Solution)
Price$63
Updated2026-05-26
Buy

ManufacturerArctom
Product numberHY-13749
Product descriptionSitagliptin 99.94%
Packaging200mg
Price$69
Updated2026-05-26
Buy

ManufacturerArctom
Product numberSLK-S5079
Product descriptionSitagliptin 99.91%
Packaging10mM(1mLinDMSO)
Price$188
Updated2026-05-26
Buy

ManufacturerArctom
Product numberHY-13749
Product descriptionSitagliptin 99.94%
Packaging500mg
Price$114
Updated2026-05-26
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
AK Scientific	X4663	Sitagliptin	100mg	$95	2021-12-16	Buy
AK Scientific	J96214	Sitagliptin	10g	$160	2021-12-16	Buy
Ambeed	A127061	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%	10g	$158	2021-12-16	Buy
Ambeed	A127061	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%	25g	$247	2021-12-16	Buy
Ambeed	A127061	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%	5g	$99	2021-12-16	Buy
Ambeed	A127061	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%	100mg	$8	2021-12-16	Buy
Ambeed	A127061	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%	250mg	$13	2021-12-16	Buy
Ambeed	A127061	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 98+%	1g	$33	2021-12-16	Buy
American Custom Chemicals Corporation	RDL0007146	SITAGLIPTIN-D4 95.00%	5MG	$497.41	2021-12-16	Buy
Arctom	SLK-S5079	Sitagliptin 99.91%	1g	$922	2026-05-26	Buy
Arctom	HY-13749	Sitagliptin 99.94%	100mg	$57	2026-05-26	Buy
Arctom	HY-13749	Sitagliptin 99.94%	10mM*1mLinDMSO(Solid+Solvent)	$63	2026-05-26	Buy
Arctom	HY-13749	Sitagliptin 99.94%	10mM*1mLinDMSO(Solution)	$63	2026-05-26	Buy
Arctom	HY-13749	Sitagliptin 99.94%	200mg	$69	2026-05-26	Buy
Arctom	SLK-S5079	Sitagliptin 99.91%	10mM(1mLinDMSO)	$188	2026-05-26	Buy
Arctom	HY-13749	Sitagliptin 99.94%	500mg	$114	2026-05-26	Buy

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Properties

Melting point :114.1-115.7 °C
Boiling point :529.9±60.0 °C(Predicted)
Density :1.61±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : ≥ 50 mg/mL (122.76 mM)
pka :7.20±0.10(Predicted)
form :Solid
color :White to off-white
optical activity :-25.4620° (C=0.4167 g/100ml, CHCL3, 20°C, 589nm)
InChI :InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
InChIKey :MFFMDFFZMYYVKS-SECBINFHSA-N
SMILES :C(N1CCN2C(C(F)(F)F)=NN=C2C1)(=O)C[C@H](N)CC1=CC(F)=C(F)C=C1F
CAS DataBase Reference :486460-32-6(CAS DataBase Reference)
EPA Substance Registry System :1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)- (486460-32-6)

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is a first-in-class oral drug launched for the treatment of type 2 diabetes. It acts by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. Incretin hormones, including glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. When blood glucose concentrations are normal or elevated,GLP-1 and GIP increase the synthesis and release of insulin from pancreatic b cells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic αcells, which leads to reduced hepatic glucose production.

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Suppliers and manufacturers

Changzhou Ruiming Pharmaceutical Co., LTD

$0.00 /25KG
Sitagliptin CAS:486460-32-6

Anhui Ruihan Technology Co., Ltd

$30.00 /1kg
Sitagliptin CAS:486460-32-6

HangZhou RunYan Pharma Technology Co.,LTD.

$0.00 /10g
Sitagliptin CAS:486460-32-6

Hainan Fubai Trading Co., LTD

$1.00 /10g
Sitagliptin CAS:486460-32-6

Hebei Chuanghai Biotechnology Co., Ltd

$10.00 /25kg
Sitagliptin CAS:486460-32-6

Hebei Yanxi Chemical Co., Ltd.

$50.00 /1kg
Sitagliptin CAS:486460-32-6

Shanghai UCHEM Inc.

$46.00 /1g
Sitagliptin CAS:486460-32-6

Hebei Dangtong Import and export Co LTD

$65.00 /1000kg
Sitagliptin CAS:486460-32-6

Henan Fengda Chemical Co., Ltd

$1.00 /100kg
Sitagliptin CAS:486460-32-6

S&Y Biochem Co.,Ltd

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Sitagliptin

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