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ChemicalBook >> CAS DataBase List >> TAK-960

TAK-960

TAK-960 price.
  • $62 - $11900
  • Product name: TAK-960
  • CAS: 1137868-52-0
  • MF: C27H34F3N7O3
  • MW: 561.6
  • EINECS:
  • MDL Number:MFCD22420821
  • Synonyms:TAK-960;4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide;4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide;CS-1725;TAK 960;TAK960;CS-554;Benzamide, 4-[(9-cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)-;Polo-like Kinase (PLK),cell,cancer,proliferation,Inhibitor,mitosis,TAK960,TAK 960,leukemia,inhibit,phosphorylation,lines,TAK-960
Price25 Properties Safety Information Description
25 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
Package
  • 1mg
  • 5MG
  • 10mg
  • 10mM(in 1mL DMSO)
  • 50mg
  • 100mg
  • 250mg
  • 1G
  • 1000mg
  • ManufacturerAK Scientific
  • Product number2743AH
  • Product descriptionTAK-960
  • Packaging50mg
  • Price$378
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0017272
  • Product descriptionTAK-960 95.00%
  • Packaging5MG
  • Price$457.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0017272
  • Product descriptionTAK-960 95.00%
  • Packaging1G
  • Price$11900
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5860
  • Product descriptionTAK960
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5860
  • Product descriptionTAK960
  • Packaging10mM(in 1mL DMSO)
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5860
  • Product descriptionTAK960
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5860
  • Product descriptionTAK960
  • Packaging50mg
  • Price$540
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181158
  • Product descriptionTAK-960 >99.8%
  • Packaging100mg
  • Price$912.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181158
  • Product descriptionTAK-960 >99.8%
  • Packaging250mg
  • Price$1654.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181158
  • Product descriptionTAK-960 >99.8%
  • Packaging1000mg
  • Price$3432.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFT104283
  • Product descriptionTAK 960
  • Packaging10mg
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFT104283
  • Product descriptionTAK 960
  • Packaging50mg
  • Price$647.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17701
  • Product descriptionTAK-960 ≥95%
  • Packaging1mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17701
  • Product descriptionTAK-960 ≥95%
  • Packaging5mg
  • Price$270
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17701
  • Product descriptionTAK-960 ≥95%
  • Packaging10mg
  • Price$419
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17701
  • Product descriptionTAK-960 ≥95%
  • Packaging50mg
  • Price$1189
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2743AH TAK-960 50mg $378 2021-12-16 Buy
American Custom Chemicals Corporation API0017272 TAK-960 95.00% 5MG $457.5 2021-12-16 Buy
American Custom Chemicals Corporation API0017272 TAK-960 95.00% 1G $11900 2021-12-16 Buy
ApexBio Technology B5860 TAK960 5mg $120 2021-12-16 Buy
ApexBio Technology B5860 TAK960 10mM(in 1mL DMSO) $160 2021-12-16 Buy
ApexBio Technology B5860 TAK960 10mg $175 2021-12-16 Buy
ApexBio Technology B5860 TAK960 50mg $540 2021-12-16 Buy
Biorbyt Ltd orb181158 TAK-960 >99.8% 100mg $912.9 2021-12-16 Buy
Biorbyt Ltd orb181158 TAK-960 >99.8% 250mg $1654.1 2021-12-16 Buy
Biorbyt Ltd orb181158 TAK-960 >99.8% 1000mg $3432.3 2021-12-16 Buy
Biosynth Carbosynth FT104283 TAK 960 10mg $185 2021-12-16 Buy
Biosynth Carbosynth FT104283 TAK 960 50mg $647.5 2021-12-16 Buy
Cayman Chemical 17701 TAK-960 ≥95% 1mg $62 2024-03-01 Buy
Cayman Chemical 17701 TAK-960 ≥95% 5mg $270 2024-03-01 Buy
Cayman Chemical 17701 TAK-960 ≥95% 10mg $419 2024-03-01 Buy
Cayman Chemical 17701 TAK-960 ≥95% 50mg $1189 2024-03-01 Buy
Next Last

Properties

Density :1.39±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥28.05 mg/mL in DMSO; insoluble in H2O; ≥12.3 mg/mL in EtOH
form :solid
pka :13.21±0.20(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively. It exhibits greater than 20-fold selectivity for Plk1 over FAK, MLCK, and the tyrosine protein kinase Fes, and has minimal activity against a panel of 282 other kinases. It inhibits the proliferation of various cancer cell lines, including MDR1-expressing tumors, and also prevents tumor growth in several human cancer cell xenograft models, including a disseminated model of AML- and MDR1-expressing hematological tumors.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
TAK-960
$58.00 /1mg
TAK-960 CAS:1137868-52-0
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aceschem Inc.
Zibo Hangyu Biotechnology Development Co., Ltd
Aladdin Scientific
Suzhou ARTK Medchem Co., Ltd.