Tafamidis
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- $62 - $1791
- Product name: Tafamidis
- CAS: 594839-88-0
- MF: C14H7Cl2NO3
- MW: 308.12
- EINECS:
- MDL Number:MFCD16621109
- Synonyms:Fx 1006;6-Benzoxazolecarboxylic acid, 2-(3,5-dichlorophenyl)-;2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid;Tafamidis (Fx1006A);Tafamidis free acid;PF-06291826(Tafamidis);Tafamidis(Fx 1006);Fx 1006A
15 prices
Selected condition：
Brand
- AK Scientific
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- Crysdot
- DC Chemicals
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- 10 mg
- 25 mg
- 50 mg
- ManufacturerAK Scientific
- Product number3096AH
- Product descriptionTafamidis
- Packaging1mg
- Price$62
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD27988
- Product description2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid
- Packaging1mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD27988
- Product description2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid
- Packaging2mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD27988
- Product description2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid
- Packaging5mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD27988
- Product description2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid
- Packaging10mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD27988
- Product description2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid
- Packaging25mg
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13694
- Product descriptionTafamidis ≥98%
- Packaging5mg
- Price$67
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13694
- Product descriptionTafamidis ≥98%
- Packaging10 mg
- Price$107
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13694
- Product descriptionTafamidis ≥98%
- Packaging25 mg
- Price$217
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13694
- Product descriptionTafamidis ≥98%
- Packaging50 mg
- Price$398
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM161229
- Product description2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylicacid 98%
- Packaging100mg
- Price$1791
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31001360
- Product descriptionTafamidis 98+%
- Packaging25mg
- Price$249
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31001360
- Product descriptionTafamidis 98+%
- Packaging50mg
- Price$425
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31001360
- Product descriptionTafamidis 98+%
- Packaging100mg
- Price$731
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10756
- Product descriptionPF-06291826(Tafamidis) >98%
- Packaging1g
- Price$1400
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3096AH | Tafamidis | 1mg | $62 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD27988 | 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid | 1mg | $96 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD27988 | 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid | 2mg | $160 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD27988 | 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid | 5mg | $320 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD27988 | 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid | 10mg | $540 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD27988 | 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid | 25mg | $900 | 2021-12-16 | Buy |
| Cayman Chemical | 13694 | Tafamidis ≥98% | 5mg | $67 | 2024-03-01 | Buy |
| Cayman Chemical | 13694 | Tafamidis ≥98% | 10 mg | $107 | 2024-03-01 | Buy |
| Cayman Chemical | 13694 | Tafamidis ≥98% | 25 mg | $217 | 2024-03-01 | Buy |
| Cayman Chemical | 13694 | Tafamidis ≥98% | 50 mg | $398 | 2024-03-01 | Buy |
| Chemenu | CM161229 | 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylicacid 98% | 100mg | $1791 | 2021-12-16 | Buy |
| Crysdot | CD31001360 | Tafamidis 98+% | 25mg | $249 | 2021-12-16 | Buy |
| Crysdot | CD31001360 | Tafamidis 98+% | 50mg | $425 | 2021-12-16 | Buy |
| Crysdot | CD31001360 | Tafamidis 98+% | 100mg | $731 | 2021-12-16 | Buy |
| DC Chemicals | DC10756 | PF-06291826(Tafamidis) >98% | 1g | $1400 | 2021-12-16 | Buy |
Properties
Boiling point :486.7±40.0 °C(Predicted)
Density :1.530
storage temp. :-20°
solubility :Soluble in DMSO (up to 20 mg/ml).
form :solid
pka :3.49±0.30(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI :InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)
InChIKey :TXEIIPDJKFWEEC-UHFFFAOYSA-N
SMILES :O1C2=CC(C(O)=O)=CC=C2N=C1C1=CC(Cl)=CC(Cl)=C1
Density :1.530
storage temp. :-20°
solubility :Soluble in DMSO (up to 20 mg/ml).
form :solid
pka :3.49±0.30(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI :InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)
InChIKey :TXEIIPDJKFWEEC-UHFFFAOYSA-N
SMILES :O1C2=CC(C(O)=O)=CC=C2N=C1C1=CC(Cl)=CC(Cl)=C1
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1 = 3 nM; Kd2 = 278 nM) to stabilize the TTR dimer-dimer interface and inhibit tetrameric dissociation. Tafamidis stabilizes wild-type and clinically significant V30M and V122I mutant TTR amyloidogenic homotetramers (EC50s = 2.7-3.2 μM) under fibril-promoting, denaturing, and physiological conditions in vitro. It stabilizes TTR heterotetramers containing wild-type and mutant subunits ex vivo in human plasma derived from patients carrying V30M or V1221 mutations when used at a concentration of 7.2 μM. Formulations containing tafamidis have been used for the treatment of familial amyloid polyneuropathy.More related product prices
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
CONIER CHEM AND PHARMA LIMITED
Shaanxi Dideu Medichem Co. Ltd
Chemia Biotechnology（Shanghai） Co., Ltd
Finetech Industry Limited
