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ChemicalBook >> CAS DataBase List >> Tezacaftor

Tezacaftor

Tezacaftor price.
  • $9 - $1600
  • Product name: Tezacaftor
  • CAS: 1152311-62-0
  • MF: C26H27F3N2O6
  • MW: 520.5
  • EINECS:
  • MDL Number:MFCD23106064
  • Synonyms:VX-661/VX661;Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-;1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide VX661;(R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-;CS-956;VX661/Tezacaftor;VX 661; VX661;VX-661;1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)indol-5-yl]cyclopropane-1-carboxamide
Price67 Properties Safety Information Description
67 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 0.025g
  • 0.05g
  • 200mg
  • 10mM(in1mLDMSO)
  • 0.1g
  • 10mM*1mLinDMSO
  • 0.25g
  • 500mg
  • 10mM(in 1mL DMSO)
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1G
  • Manufactureraablocks
  • Product numberAA000GEW
  • Product description1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide 99%
  • Packaging1mg
  • Price$9
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000GEW
  • Product description1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide ≥98%
  • Packaging5mg
  • Price$12
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000GEW
  • Product description1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide ≥98%
  • Packaging10mg
  • Price$22
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000GEW
  • Product description1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide 99%
  • Packaging25mg
  • Price$41
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000GEW
  • Product description1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide 99%
  • Packaging100mg
  • Price$114
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000GEW
  • Product description1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide 99%
  • Packaging250mg
  • Price$237
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberG-6563
  • Product descriptionVX-661 98%
  • Packaging100MG
  • Price$80
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberG-6563
  • Product descriptionVX-661 98%
  • Packaging100MG
  • Price$80
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberG-6563
  • Product descriptionVX-661 98%
  • Packaging1G
  • Price$520
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberG-6563
  • Product descriptionVX-661 98%
  • Packaging1G
  • Price$520
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product numberY0430
  • Product description(R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
  • Packaging250mg
  • Price$725
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberY0430
  • Product description(R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
  • Packaging100mg
  • Price$428
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA2664
  • Product descriptionVX-661
  • Packaging50mg
  • Price$440
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA2664
  • Product descriptionVX-661
  • Packaging50mg
  • Price$440
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA2664
  • Product descriptionVX-661
  • Packaging10mM(in 1mL DMSO)
  • Price$115
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA2664
  • Product descriptionVX-661
  • Packaging5mg
  • Price$100
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA000GEW 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide 99% 1mg $9 2026-05-25 Buy
aablocks AA000GEW 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide ≥98% 5mg $12 2026-05-25 Buy
aablocks AA000GEW 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide ≥98% 10mg $22 2026-05-25 Buy
aablocks AA000GEW 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide 99% 25mg $41 2026-05-25 Buy
aablocks AA000GEW 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide 99% 100mg $114 2026-05-25 Buy
aablocks AA000GEW 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide 99% 250mg $237 2026-05-25 Buy
ACHEMBLOCK G-6563 VX-661 98% 100MG $80 2026-05-25 Buy
ACHEMBLOCK G-6563 VX-661 98% 100MG $80 2026-05-27 Buy
ACHEMBLOCK G-6563 VX-661 98% 1G $520 2026-05-25 Buy
ACHEMBLOCK G-6563 VX-661 98% 1G $520 2026-05-27 Buy
AK Scientific Y0430 (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide 250mg $725 2021-12-16 Buy
AK Scientific Y0430 (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide 100mg $428 2021-12-16 Buy
ApexBio Technology A2664 VX-661 50mg $440 2021-12-16 Buy
ApexBio Technology A2664 VX-661 50mg $440 2026-05-06 Buy
ApexBio Technology A2664 VX-661 10mM(in 1mL DMSO) $115 2021-12-16 Buy
ApexBio Technology A2664 VX-661 5mg $100 2021-12-16 Buy
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Properties

Boiling point :610.8±55.0 °C(Predicted)
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C , stored under nitrogen
solubility :≥21.8 mg/mL in DMSO; insoluble in EtOH; ≥24.3 mg/mL in H2O
form :solid
pka :13.99±0.20(Predicted)
color :White to yellow
InChIKey :MJUVRTYWUMPBTR-MRXNPFEDSA-N
SMILES :C1(C2=CC=C3OC(F)(F)OC3=C2)(C(NC2C(F)=CC3=C(C=2)C=C(C(C)(C)CO)N3C[C@@H](O)CO)=O)CC1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Tezacaftor (VX-661) is an oral medication for cystic fibrosis (CF) developed by Vertex Pharmaceuticals. In a combination therapy formulation called Symdeko (tezacaftor plus ivacaftor), it is approved in the U.S. and Canada for CF patients, ages 12 and older, who have two copies of the F508del mutation in the CFTR gene and one minimal function mutation. Symdeko is approved and marketed in the EU as Symkevi.Tezacaftor is not approved as a stand-alone treatment, but as part of a combination therapy.

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Suppliers and manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Tezacaftor
Tezacaftor CAS:1152311-62-0
career henan chemical co
VX-661
$8.00
VX-661 CAS: 1152311-62-0
TargetMol Chemicals Inc.
Tezacaftor
$34.00
Tezacaftor CAS:1152311-62-0
Qiuxian Baitai New Material Co., LTD
VX-661
VX-661 CAS:1152311-62-0
Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd.
Shandong Juntai Pharmaceutical Co. , Ltd.
Biochempartner
CONIER CHEM AND PHARMA LIMITED
ENBRIDGE PHARMTECH CO., LTD.
HANGZHOU CLAP TECHNOLOGY CO.,LTD