UMI-77
|
- $26 - $3772
- Product name: UMI-77
- CAS: 518303-20-3
- MF: C18H14BrNO5S2
- MW: 468.34
- EINECS:
- MDL Number:MFCD03471890
- Synonyms:2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid;UMI-77;2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid;2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid UMI-77;Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-;UMI 77;UMI77;CS-1799;UMI-77 USP/EP/BP
45 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM(in1mLDMSO)
- 10mM(1mLinDMSO)
- 1g
- 10mM*1mLinDMSO
- 250mg
- 10mM(in 1mL DMSO)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- Manufactureraablocks
- Product numberAA00DB6N
- Product descriptionUMI-77 97%
- Packaging1mg
- Price$26
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB6N
- Product descriptionUMI-77 97%
- Packaging5mg
- Price$53
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB6N
- Product descriptionUMI-77 97%
- Packaging10mg
- Price$79
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB6N
- Product descriptionUMI-77 97%
- Packaging25mg
- Price$165
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB6N
- Product descriptionUMI-77 97%
- Packaging50mg
- Price$238
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB6N
- Product descriptionUMI-77 97
- Packaging100mg
- Price$445
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB6N
- Product descriptionUMI-77 97
- Packaging200mg
- Price$635
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228648
- Product descriptionUMI-77 97.00%
- Packaging100MG
- Price$635
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228648
- Product descriptionUMI-77 97.00%
- Packaging25MG
- Price$265
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2780AH
- Product description2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)aceticacid
- Packaging50mg
- Price$517
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004698
- Product descriptionUMI-77 95.00%
- Packaging5MG
- Price$500.67
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4881
- Product descriptionUMI-77
- Packaging25mg
- Price$396
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4881
- Product descriptionUMI-77
- Packaging5mg
- Price$110
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4881
- Product descriptionUMI-77
- Packaging10mM(in 1mL DMSO)
- Price$115
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4881
- Product descriptionUMI-77
- Packaging10mM(in1mLDMSO)
- Price$116
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-18628
- Product descriptionUMI-77 99.66%
- Packaging10mg
- Price$143
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00DB6N | UMI-77 97% | 1mg | $26 | 2026-05-28 | Buy |
| aablocks | AA00DB6N | UMI-77 97% | 5mg | $53 | 2026-05-28 | Buy |
| aablocks | AA00DB6N | UMI-77 97% | 10mg | $79 | 2026-05-28 | Buy |
| aablocks | AA00DB6N | UMI-77 97% | 25mg | $165 | 2026-05-28 | Buy |
| aablocks | AA00DB6N | UMI-77 97% | 50mg | $238 | 2026-05-28 | Buy |
| aablocks | AA00DB6N | UMI-77 97 | 100mg | $445 | 2026-05-28 | Buy |
| aablocks | AA00DB6N | UMI-77 97 | 200mg | $635 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228648 | UMI-77 97.00% | 100MG | $635 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228648 | UMI-77 97.00% | 25MG | $265 | 2026-05-27 | Buy |
| AK Scientific | 2780AH | 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)aceticacid | 50mg | $517 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004698 | UMI-77 95.00% | 5MG | $500.67 | 2021-12-16 | Buy |
| ApexBio Technology | B4881 | UMI-77 | 25mg | $396 | 2026-05-06 | Buy |
| ApexBio Technology | B4881 | UMI-77 | 5mg | $110 | 2026-05-06 | Buy |
| ApexBio Technology | B4881 | UMI-77 | 10mM(in 1mL DMSO) | $115 | 2021-12-16 | Buy |
| ApexBio Technology | B4881 | UMI-77 | 10mM(in1mLDMSO) | $116 | 2026-05-06 | Buy |
| Arctom | HY-18628 | UMI-77 99.66% | 10mg | $143 | 2026-05-26 | Buy |
Properties
Boiling point :661.2±65.0 °C(Predicted)
Density :1.79±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23.4 mg/mL in DMSO; insoluble in H2O; ≥7.2 mg/mL in EtOH
form :solid
pka :2.41±0.30(Predicted)
color :White to off-white
InChI :InChI=1S/C18H14BrNO5S2/c19-11-5-7-12(8-6-11)27(24,25)20-15-9-16(26-10-17(21)22)18(23)14-4-2-1-3-13(14)15/h1-9,20,23H,10H2,(H,21,22)
InChIKey :WUGANDSUVKXMEC-UHFFFAOYSA-N
SMILES :C(O)(=O)CSC1=CC(NS(C2=CC=C(Br)C=C2)(=O)=O)=C2C(=C1O)C=CC=C2
Density :1.79±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23.4 mg/mL in DMSO; insoluble in H2O; ≥7.2 mg/mL in EtOH
form :solid
pka :2.41±0.30(Predicted)
color :White to off-white
InChI :InChI=1S/C18H14BrNO5S2/c19-11-5-7-12(8-6-11)27(24,25)20-15-9-16(26-10-17(21)22)18(23)14-4-2-1-3-13(14)15/h1-9,20,23H,10H2,(H,21,22)
InChIKey :WUGANDSUVKXMEC-UHFFFAOYSA-N
SMILES :C(O)(=O)CSC1=CC(NS(C2=CC=C(Br)C=C2)(=O)=O)=C2C(=C1O)C=CC=C2
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Myeloid cell leukemia-1 (Mcl-1) is a potent anti-apoptotic protein and a member of the pro-survival Bcl-2 family. UMI-77 is a selective Mcl-1 inhibitor with a Ki value of 490 nM and exhibits selectivity over other members of the Bcl-2 family (Kis = 5.3, 23.8, 33.0, and 8.2 μM) for A1/Bfl-1, Bcl-2, Bcl-xL, and Bcl-W, respectively). It has been shown to disrupt the heterodimerization of Mcl-1/Bax and Mcl-1/Bak, thus antagonizing Mcl-1 function. UMI-77 inhibits the growth of various pancreatic cancer cell lines with IC50s values ranging from 3.4-16.1 μM, inducing apoptosis through activation of the intrinsic apoptotic pathway and/or Bax conformational change. In a BxPC-3 xenograft mouse model, 60 mg/kg UMI-77 demonstrated antitumor activity without damaging normal tissues.Related product price
-
ABT 263
$24-2245.7 -
ABT 737
$27-2822 -
Panobinostat
$10-4735.5
Suppliers and manufacturers
Wuhan Augda Biotechnology Co., Ltd
Shanghai Boyle Chemical Co., Ltd.
Dalian Meilun Biotech Co., Ltd.
Haoyuan Chemexpress Co., Ltd.
MedChemexpress LLC
AdooQ Bioscience CHINA
Shanghai Lollane Biological Technology Co.,Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.
Shanghai QianYan Bio-technology Co., Ltd
Target molecule Corp.