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ChemicalBook >> CAS DataBase List >> URMC-099

URMC-099

URMC-099 price.
  • $29 - $1782
  • Product name: URMC-099
  • CAS: 1229582-33-5
  • MF: C27H27N5
  • MW: 421.54
  • EINECS:
  • MDL Number:MFCD28168077
  • Synonyms:3-(1H-indol-5-yl)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine URMC-099;URMC-099;3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine;1H-?Pyrrolo[2,?3-?b]?pyridine, 3-?(1H-?indol-?5-?yl)?-?5-?[4-?[(4-?methyl-?1-?piperazinyl)?methyl]?phenyl]?-;CS-1776;URMC-099;URMC 099;RMC099;inhibit,MLKs,Autophagy,URMC 099,URMC099,URMC-099,Inhibitor,Mixed Lineage Kinase
Price22 Properties Safety Information Description
22 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
Package
  • 5mg
  • 25mg
  • 50mg
  • 10mM(in 1mL DMSO)
  • 1mg
  • 10mg
  • 100mg
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1211-M005
  • Product descriptionURMC-099 ≥95%(HPLC)
  • Packaging5mg
  • Price$194
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1211-M100
  • Product descriptionURMC-099 ≥95%(HPLC)
  • Packaging100mg
  • Price$1782
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX3562
  • Product descriptionURMC-099
  • Packaging10mg
  • Price$172
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1211
  • Product descriptionURMC-099
  • Packaging5mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4877
  • Product descriptionURMC-099
  • Packaging5mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4877
  • Product descriptionURMC-099
  • Packaging10mM(in 1mL DMSO)
  • Price$132
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4877
  • Product descriptionURMC-099
  • Packaging25mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4877
  • Product descriptionURMC-099
  • Packaging100mg
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFU170951
  • Product descriptionURMC 099
  • Packaging50mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFU170951
  • Product descriptionURMC 099
  • Packaging100mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19147
  • Product descriptionURMC-099 ≥95%
  • Packaging1mg
  • Price$29
  • Updated2022-04-27
  • Buy
  • ManufacturerCayman Chemical
  • Product number19147
  • Product descriptionURMC-099 ≥95%
  • Packaging5mg
  • Price$60
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19147
  • Product descriptionURMC-099 ≥95%
  • Packaging10mg
  • Price$99
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19147
  • Product descriptionURMC-099 ≥95%
  • Packaging25mg
  • Price$162
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM148925
  • Product description3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine 95%+
  • Packaging10mg
  • Price$211
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4182
  • Product descriptionURMC-099 99.90%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1211-M005 URMC-099 ≥95%(HPLC) 5mg $194 2021-12-16 Buy
Adipogen Life Sciences SYN-1211-M100 URMC-099 ≥95%(HPLC) 100mg $1782 2021-12-16 Buy
AK Scientific X3562 URMC-099 10mg $172 2021-12-16 Buy
AK Scientific SYN1211 URMC-099 5mg $200 2021-12-16 Buy
ApexBio Technology B4877 URMC-099 5mg $95 2021-12-16 Buy
ApexBio Technology B4877 URMC-099 10mM(in 1mL DMSO) $132 2021-12-16 Buy
ApexBio Technology B4877 URMC-099 25mg $280 2021-12-16 Buy
ApexBio Technology B4877 URMC-099 100mg $720 2021-12-16 Buy
Biosynth Carbosynth FU170951 URMC 099 50mg $250 2021-12-16 Buy
Biosynth Carbosynth FU170951 URMC 099 100mg $400 2021-12-16 Buy
Cayman Chemical 19147 URMC-099 ≥95% 1mg $29 2022-04-27 Buy
Cayman Chemical 19147 URMC-099 ≥95% 5mg $60 2024-03-01 Buy
Cayman Chemical 19147 URMC-099 ≥95% 10mg $99 2024-03-01 Buy
Cayman Chemical 19147 URMC-099 ≥95% 25mg $162 2024-03-01 Buy
Chemenu CM148925 3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine 95%+ 10mg $211 2021-12-16 Buy
ChemScene CS-4182 URMC-099 99.90% 5mg $60 2021-12-16 Buy
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Properties

Density :1.256±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :13.49±0.40(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :QKKIWEILHCXECO-UHFFFAOYSA-N
SMILES :C12NC=C(C3C=CC4=C(C=3)C=CN4)C1=CC(C1=CC=C(CN3CCN(C)CC3)C=C1)=CN=2

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

URMC-099 is an orally bioavailable, brain-penetrant inhibitor of mixed-lineage kinases (MLKs) with IC50 values of 19, 42, 14, and 150 nM for MLK1, MLK2, MLK3, and the related MLK family member DLK, respectively. It also inhibits LRRK2 activity with an IC50 value of 11 nM. In vitro, URMC-099 has been shown to reduce inflammatory cytokine production by HIV-1 Tat-exposed microglia and to prevent destruction and phagocytosis of cultured neuronal axons by these cells. In rodent models of HIV-associated neurocognitive disorders, URMC-099 demonstrates anti-inflammatory and neuroprotective effects.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
URMC-099
$52.00 /5mg
URMC-099 CAS:1229582-33-5
ATK CHEMICAL COMPANY LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Chemia Biotechnology（Shanghai） Co., Ltd
Zhejiang J&C Biological Technology Co.,Limited
Hangzhou MolCore BioPharmatech Co.,Ltd.
Nantong HI-FUTURE Biology Co., Ltd.
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd