Unii-0789652qul
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- $128 - $795
- Product name: Unii-0789652qul
- CAS: 130112-42-4
- MF: C12H14N2O3S3
- MW: 330.45
- EINECS:
- MDL Number:MFCD02752797
- Synonyms:Ccris 8109;Isopropyl 2-(1,3-dithietane-2-ylidine)-2-(N-(4-methyl-2-thiazol-2-yl)carbamoyl)acetate;Mivotilate;Mivotilate [inn];Unii-0789652qul;2-(1,3-Dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-propanoic acid 1-methylethyl ester;Isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methyl2-thiazol-2-yl)carbamoyl] acetate;Propanoic acid, 2-(1,3-dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-, 1-methylethyl ester
8 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ChemScene
- CSNpharm
- Sigma-Aldrich
Package
- 1mg
- 5MG
- 10mg
- 25mg
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0295004
- Product description2-(1,3-DITHIETAN-2-YLIDENE)-3-[(4-METHYL-2-THIAZOLYL)AMINO]-3-OXO-PROPANOIC ACID-1-METHYLETHYL ESTER 95.00%
- Packaging5MG
- Price$504.53
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0018393
- Product descriptionMivotilate >98.0%
- Packaging5mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0018393
- Product descriptionMivotilate >98.0%
- Packaging10mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN22230
- Product descriptionMivotilate
- Packaging1mg
- Price$128
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN22230
- Product descriptionMivotilate
- Packaging5mg
- Price$383
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN22230
- Product descriptionMivotilate
- Packaging10mg
- Price$638
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberY1646
- Product descriptionYH439 ≥98% (HPLC)
- Packaging5mg
- Price$165
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberY1646
- Product descriptionYH439 ≥98% (HPLC)
- Packaging25mg
- Price$795
- Updated2023-01-07
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CHM0295004 | 2-(1,3-DITHIETAN-2-YLIDENE)-3-[(4-METHYL-2-THIAZOLYL)AMINO]-3-OXO-PROPANOIC ACID-1-METHYLETHYL ESTER 95.00% | 5MG | $504.53 | 2021-12-16 | Buy |
| ChemScene | CS-0018393 | Mivotilate >98.0% | 5mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0018393 | Mivotilate >98.0% | 10mg | $750 | 2021-12-16 | Buy |
| CSNpharm | CSN22230 | Mivotilate | 1mg | $128 | 2021-12-16 | Buy |
| CSNpharm | CSN22230 | Mivotilate | 5mg | $383 | 2021-12-16 | Buy |
| CSNpharm | CSN22230 | Mivotilate | 10mg | $638 | 2021-12-16 | Buy |
| Sigma-Aldrich | Y1646 | YH439 ≥98% (HPLC) | 5mg | $165 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y1646 | YH439 ≥98% (HPLC) | 25mg | $795 | 2023-01-07 | Buy |
Properties
Density :1.467±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥5mg/mL
form :solid
pka :4.89±0.70(Predicted)
color :Light yellow to yellow
storage temp. :2-8°C
solubility :DMSO: ≥5mg/mL
form :solid
pka :4.89±0.70(Predicted)
color :Light yellow to yellow
Safety Information
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Description
Mivotilate is an orally-active hepatoprotective agent introduced for the treatment of liver cirrhosis and hepatitis-B infection. It is a dithietanylidene malonate analogue of malotilate and is without the haemotological adverse effects associated with the latter. Mivotilate can be obtained by partial saponification of the corresponding diisopropylmalonate, conversion of the acid function into mixed anhydride then to the amide with an aminothiazole. It displays potent hepatoprotective activity in rat and mice liver injury models by a mechanism involving the inactivation of Kupffer cells. Mivotilate was shown to exert multiple effects on the hepatic cytochrome P450 system, particularly to inhibit CYP2E1 expression and to up-regulate the CYP1A1 expression. The low oral bioavailability of Mivotilate in rats (F<0.22%) could be primarilly attributed to poor absorption and considerable hepatic and gastrointestinal first-pass effects. Mivotilate prevents mutagenesis caused by agents such as benzo[a]pyrene and reduces skin tumors induced by these agents.Suppliers and manufacturers
TargetMol Chemicals Inc.
Jilin Chinese Academy of Sciences-yanshen Technology
Aladdin Scientific
Beijing HuaMeiHuLiBiological Chemical
Fan De(Beijing) Biotechnology Co., Ltd.
Energy Chemical
Beijing Jin Ming Biotechnology Co., Ltd.
ChemeGen
Kaifeng Mingren Pharmaceutical Co.,LTD
