Upadacitinib
|
- $9 - $5000
- Product name: Upadacitinib
- CAS: 1310726-60-3
- MF: C17H19F3N6O
- MW: 380.37
- EINECS:213-161-9
- MDL Number:MFCD30502663
- Synonyms:Upadacitinib;ABT-494 (Upadacitinib);Upadacitinib (Rinvoq);ABT-494; ABT494; ABT 494;CS-2730;Upacidatinib;Upadacitinib (ABT-494);(3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, Upadacitinib
82 prices
Selected condition：
Brand
- A2B
- aablocks
- ACHEMBLOCK
- AK Scientific
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 0.25g
- 250mg
- 0.5g
- 1g
- 2g
- 500mg
- 10mM*1mLinDMSO
- 10g
- 25g
- 10mM*1mLinDMSO(Solid+Solvent)
- 5g
- 10mM*1mLinDMSO(Solution)
- ManufacturerA2B
- Product numberAX33698
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98%
- Packaging1mg
- Price$9
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAX33698
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98%
- Packaging5mg
- Price$21
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAX33698
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98%
- Packaging10mg
- Price$32
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAX33698
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98%
- Packaging25mg
- Price$61
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAX33698
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98%
- Packaging50mg
- Price$108
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAX33698
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98%
- Packaging100mg
- Price$173
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAX33698
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98%
- Packaging250mg
- Price$252
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAX33698
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98%
- Packaging500mg
- Price$329
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAX33698
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98%
- Packaging1g
- Price$588
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAX33698
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98%
- Packaging5g
- Price$1955
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAX33698
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98%
- Packaging25g
- Price$4516
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA01E0RQ
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98%
- Packaging25g
- Price$4767
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0RQ
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98%
- Packaging5g
- Price$2064
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0RQ
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 99%
- Packaging1g
- Price$588
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0RQ
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide ≥99%
- Packaging500mg
- Price$430
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E0RQ
- Product description(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 99%
- Packaging250mg
- Price$252
- Updated2026-05-30
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| A2B | AX33698 | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98% | 1mg | $9 | 2026-05-25 | Buy |
| A2B | AX33698 | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98% | 5mg | $21 | 2026-05-25 | Buy |
| A2B | AX33698 | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98% | 10mg | $32 | 2026-05-25 | Buy |
| A2B | AX33698 | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98% | 25mg | $61 | 2026-05-25 | Buy |
| A2B | AX33698 | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98% | 50mg | $108 | 2026-05-25 | Buy |
| A2B | AX33698 | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98% | 100mg | $173 | 2026-05-25 | Buy |
| A2B | AX33698 | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98% | 250mg | $252 | 2026-05-25 | Buy |
| A2B | AX33698 | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98% | 500mg | $329 | 2026-05-25 | Buy |
| A2B | AX33698 | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98% | 1g | $588 | 2026-05-25 | Buy |
| A2B | AX33698 | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98% | 5g | $1955 | 2026-05-25 | Buy |
| A2B | AX33698 | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98% | 25g | $4516 | 2026-05-25 | Buy |
| aablocks | AA01E0RQ | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98% | 25g | $4767 | 2026-05-30 | Buy |
| aablocks | AA01E0RQ | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 98% | 5g | $2064 | 2026-05-30 | Buy |
| aablocks | AA01E0RQ | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 99% | 1g | $588 | 2026-05-30 | Buy |
| aablocks | AA01E0RQ | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide ≥99% | 500mg | $430 | 2026-05-30 | Buy |
| aablocks | AA01E0RQ | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide 99% | 250mg | $252 | 2026-05-30 | Buy |
Properties
Density :1.56±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:42.67(Max Conc. mg/mL);112.17(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.31(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);78.87(Max Conc. mM)
Ethanol:76.0(Max Conc. mg/mL);199.8(Max Conc. mM) form :A crystalline solid
pka :11.89±0.60(Predicted)
color :White to off-white
InChI :InChI=1S/C17H19F3N6O/c1-2-10-7-25(16(27)24-9-17(18,19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15/h3-6,10-11,21H,2,7-9H2,1H3,(H,24,27)/t10-,11+/m1/s1
InChIKey :WYQFJHHDOKWSHR-MNOVXSKESA-N
SMILES :N1(C(NCC(F)(F)F)=O)C[C@H](C2N3C4C=CNC=4N=CC3=NC=2)[C@H](CC)C1
storage temp. :Store at -20°C
solubility :DMSO:42.67(Max Conc. mg/mL);112.17(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.31(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);78.87(Max Conc. mM)
Ethanol:76.0(Max Conc. mg/mL);199.8(Max Conc. mM) form :A crystalline solid
pka :11.89±0.60(Predicted)
color :White to off-white
InChI :InChI=1S/C17H19F3N6O/c1-2-10-7-25(16(27)24-9-17(18,19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15/h3-6,10-11,21H,2,7-9H2,1H3,(H,24,27)/t10-,11+/m1/s1
InChIKey :WYQFJHHDOKWSHR-MNOVXSKESA-N
SMILES :N1(C(NCC(F)(F)F)=O)C[C@H](C2N3C4C=CNC=4N=CC3=NC=2)[C@H](CC)C1
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
Upadacitinib is a JAK1 inhibitor (IC50 = 47 nM). It is selective for JAK1 over JAK3 and tyrosine kinase 2 (Tyk2; IC50s = 2,304 and 4,690 nM, respectively), as well as a panel of 83 additional kinases at 1 μM, but does inhibit JAK2, Rho-associated kinase I (ROCK1), and ROCK2 (IC50s = 120, 920, and 430 nM, respectively). Upadacitinib decreases cytokine-induced STAT phosphorylation in a variety of human cells with IC50 values ranging from 1.6 to 649 nM. It reduces M. tuberculosis-induced paw swelling and bone erosion in a rat model of arthritis when administered at doses of 1, 3, and 10 mg/kg twice per day for 17 days. Formulations containing upadacitinib have been used in the treatment of rheumatoid arthritis.More related product prices
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Suppliers and manufacturers
Suzhou lipin Chemical Co., Ltd
Cangzhou Kangrui Medical Technology Co., LTD
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Hangzhou Cheminspire Technology Co., Ltd.
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Beijing Mesochem Technology Co., Ltd.
Shandong Yuhe Pharmaceutical Technology Co., LTD
Changzhou Borl Biotechnology Co.,LTD
Jinan Good Medical &Technology Ltd Co.,