VX-770
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- $28 - $25200
- Product name: VX-770
- CAS: 873054-44-5
- MF: C24H28N2O3
- MW: 392.49
- EINECS:-0
- MDL Number:MFCD17171361
- Synonyms:Ivacaftor, >=98%;3-QuinolinecarboxaMide, N-[2,4-bis(1,1-diMethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-;N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide;VX 770, Ivacaftor;Ivacaftor-D4;VX-770(Ivacattor);IVACAFTOR (VX-770);VX 770;N-(2,4-DITERT-BUTYL-5-HYDROXYPHENYL)-4-OXO-1H-QUINOLINE-3-CARBOXAMIDE
32 prices
Selected condition：
Brand
- AccelPharmtech
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 1unit
- 1MG
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- 500G
- 1KG
- 10mM(in 1mL DMSO)
- ManufacturerAccelPharmtech
- Product numberXP2372
- Product descriptionVX-770 99.00%
- Packaging500G
- Price$14700
- Updated2021-12-16
- Buy
- ManufacturerAccelPharmtech
- Product numberXP2372
- Product descriptionVX-770 99.00%
- Packaging1KG
- Price$25200
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ97241
- Product descriptionIvacaftor(VX-770)
- Packaging250mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0007687
- Product descriptionVX-770 95.00%
- Packaging1MG
- Price$148.05
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0007687
- Product descriptionVX-770 95.00%
- Packaging5MG
- Price$497.12
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5047
- Product descriptionIvacaftor(VX-770)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5047
- Product descriptionIvacaftor(VX-770)
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5047
- Product descriptionIvacaftor(VX-770)
- Packaging25mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5047
- Product descriptionIvacaftor(VX-770)
- Packaging10mM(in 1mL DMSO)
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5047
- Product descriptionIvacaftor(VX-770)
- Packaging100mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60053
- Product descriptionIvacaftor(VX-770) ≥98%
- Packaging10mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFI143182
- Product descriptionIvacaftor
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFI143182
- Product descriptionIvacaftor
- Packaging50mg
- Price$332.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15145
- Product descriptionIvacaftor ≥98%
- Packaging1mg
- Price$33
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15145
- Product descriptionIvacaftor ≥98%
- Packaging5mg
- Price$131
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15145
- Product descriptionIvacaftor ≥98%
- Packaging10mg
- Price$245
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AccelPharmtech | XP2372 | VX-770 99.00% | 500G | $14700 | 2021-12-16 | Buy |
| AccelPharmtech | XP2372 | VX-770 99.00% | 1KG | $25200 | 2021-12-16 | Buy |
| AK Scientific | J97241 | Ivacaftor(VX-770) | 250mg | $130 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007687 | VX-770 95.00% | 1MG | $148.05 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007687 | VX-770 95.00% | 5MG | $497.12 | 2021-12-16 | Buy |
| ApexBio Technology | A5047 | Ivacaftor(VX-770) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A5047 | Ivacaftor(VX-770) | 5mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A5047 | Ivacaftor(VX-770) | 25mg | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A5047 | Ivacaftor(VX-770) | 10mM(in 1mL DMSO) | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A5047 | Ivacaftor(VX-770) | 100mg | $135 | 2021-12-16 | Buy |
| Arctom | CFN60053 | Ivacaftor(VX-770) ≥98% | 10mg | $108 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FI143182 | Ivacaftor | 10mg | $95 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FI143182 | Ivacaftor | 50mg | $332.5 | 2021-12-16 | Buy |
| Cayman Chemical | 15145 | Ivacaftor ≥98% | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 15145 | Ivacaftor ≥98% | 5mg | $131 | 2024-03-01 | Buy |
| Cayman Chemical | 15145 | Ivacaftor ≥98% | 10mg | $245 | 2024-03-01 | Buy |
Properties
Melting point :212-215°C
Boiling point :550.4±50.0 °C(Predicted)
Density :1.187
storage temp. :Refrigerator
solubility :DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka :11.08±0.23(Predicted)
form :Solid
color :White to Light Brown
InChI :InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)
InChIKey :PURKAOJPTOLRMP-UHFFFAOYSA-N
SMILES :N1C2=C(C=CC=C2)C(=O)C(C(NC2=CC(O)=C(C(C)(C)C)C=C2C(C)(C)C)=O)=C1
Boiling point :550.4±50.0 °C(Predicted)
Density :1.187
storage temp. :Refrigerator
solubility :DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka :11.08±0.23(Predicted)
form :Solid
color :White to Light Brown
InChI :InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)
InChIKey :PURKAOJPTOLRMP-UHFFFAOYSA-N
SMILES :N1C2=C(C=CC=C2)C(=O)C(C(NC2=CC(O)=C(C(C)(C)C)C=C2C(C)(C)C)=O)=C1
Safety Information
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Description
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). A glycine-to-aspartic acid missense mutation at codon 551 (G551D) is a common mutation associated with a severe CF phenotype. Ivacaftor is an orally bioavailable CFTR potentiator that improves chloride transport. It increases the forskolin-induced CFTR-mediated epithelial current in cells expressing the G551D mutation by ~4-fold (EC50 = 100 nM) but has no effect on current in the absence of forskolin. Ivacaftor increases chloride secretion in cultured human CF bronchial epithelial cells carrying the G551D mutation on one allele and the common delta F508 processing mutation on the other allele. It binds CFTR directly and causes CFTR channel opening by an ATP-independent mechanism. It effectively improves sweat chloride in vivo while improving lung function when at least one G551D CFTR mutation is present.More related product prices
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