WZ8040
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- $32 - $15120
- Product name: WZ8040
- CAS: 1214265-57-2
- MF: C24H25ClN6OS
- MW: 481.01
- EINECS:-0
- MDL Number:MFCD18074511
- Synonyms:WZ8040;N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide;N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide;N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide WZ8040;N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)thio)phenyl)acrylami;CS-471;WZ-8040;WZ 8040;2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-
39 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
Package
- 10mM*1mLinDMSO
- 1mg
- 5mg
- 10mg
- 25mg
- 50MG
- 100MG
- 250mg
- 1000mg
- 1G
- 2000mg
- 10mM(in1mLDMSO)
- 10mM(in 1mL DMSO)
- Manufactureraablocks
- Product numberAA009CCX
- Product descriptionN-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide ≥98%
- Packaging1mg
- Price$32
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CCX
- Product descriptionN-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide 99%
- Packaging5mg
- Price$68
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CCX
- Product descriptionN-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide 99%
- Packaging10mg
- Price$110
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CCX
- Product descriptionN-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide
- Packaging25mg
- Price$228
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228869
- Product descriptionWZ8040 97.00%
- Packaging50MG
- Price$460
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228869
- Product descriptionWZ8040 97.00%
- Packaging100MG
- Price$680
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7483
- Product descriptionN-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide
- Packaging25mg
- Price$816
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7483
- Product descriptionN-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide
- Packaging10mg
- Price$421
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7483
- Product descriptionN-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide
- Packaging5mg
- Price$268
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000899
- Product descriptionWZ-8040 95.00%
- Packaging5MG
- Price$510
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000899
- Product descriptionWZ-8040 95.00%
- Packaging10MG
- Price$565
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000899
- Product descriptionWZ-8040 95.00%
- Packaging50MG
- Price$885
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000899
- Product descriptionWZ-8040 95.00%
- Packaging1G
- Price$10100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1393
- Product descriptionWZ8040
- Packaging100mg
- Price$880
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1393
- Product descriptionWZ8040
- Packaging25mg
- Price$396
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1393
- Product descriptionWZ8040
- Packaging10mM(in 1mL DMSO)
- Price$230
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009CCX | N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide ≥98% | 1mg | $32 | 2026-05-28 | Buy |
| aablocks | AA009CCX | N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide 99% | 5mg | $68 | 2026-05-28 | Buy |
| aablocks | AA009CCX | N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide 99% | 10mg | $110 | 2026-05-28 | Buy |
| aablocks | AA009CCX | N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide | 25mg | $228 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228869 | WZ8040 97.00% | 50MG | $460 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228869 | WZ8040 97.00% | 100MG | $680 | 2026-05-27 | Buy |
| AK Scientific | X7483 | N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide | 25mg | $816 | 2021-12-16 | Buy |
| AK Scientific | X7483 | N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide | 10mg | $421 | 2021-12-16 | Buy |
| AK Scientific | X7483 | N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide | 5mg | $268 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000899 | WZ-8040 95.00% | 5MG | $510 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000899 | WZ-8040 95.00% | 10MG | $565 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000899 | WZ-8040 95.00% | 50MG | $885 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000899 | WZ-8040 95.00% | 1G | $10100 | 2021-12-16 | Buy |
| ApexBio Technology | A1393 | WZ8040 | 100mg | $880 | 2026-05-06 | Buy |
| ApexBio Technology | A1393 | WZ8040 | 25mg | $396 | 2026-05-06 | Buy |
| ApexBio Technology | A1393 | WZ8040 | 10mM(in 1mL DMSO) | $230 | 2021-12-16 | Buy |
Properties
Density :1.37
storage temp. :Store at -20°C
solubility :≥24.05 mg/mL in DMSO; insoluble in H2O; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :12.94±0.70(Predicted)
color :Light yellow to green yellow
storage temp. :Store at -20°C
solubility :≥24.05 mg/mL in DMSO; insoluble in H2O; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :12.94±0.70(Predicted)
color :Light yellow to green yellow
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
WZ8040 is an inhibitor of mutant EGF receptors (EGFRs) with IC50 values ranging from 2 to 306 nM in Ba/F3 cells. It is selective for EGFR mutants, including the EGFRDel E746_A750 and EGFRL858R mutations conferring gefitinib sensitivity and the EGFRDel E746_A750/T790M mutation conferring gefitinib resistance (IC50s = 2, 6, and 6 nM in Ba/F3 cells), over wild-type EGFR (IC50 = 1,820 nM in HN11 cells) but also inhibits ERBB2Ins G776V,C and wild-type ERBB2 (IC50s = 20 and 32 nM, respectively, in Ba/F3 cells). WZ8040 inhibits proliferation of PC-9 cells harboring the EGFRDel E746_A750 mutation and gefitinib-resistant PC-9 GR cells harboring the EGFRT790M resistant allele (EC50s = 6 and 8 nM, respectively).More related product prices
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Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
Jinan Trio PharmaTech Co., Ltd.
China Langchem Inc.
Shanghai civi chemical technology co.,Ltd
NCE Biomedical Co.,Ltd.
AdooQ BioScience, LLC
Shanghai JONLN Reagent Co., Ltd.
Bide Pharmatech Ltd.
HangZhou YuHao Chemical Technology Co., Ltd.
Shandong Boluoda Biological Technology Co., Ltd.