WZ4002
|
- $28 - $4050
- Product name: WZ4002
- CAS: 1213269-23-8
- MF: C25H27ClN6O3
- MW: 494.97
- EINECS:206-141-6
- MDL Number:MFCD16621244
- Synonyms:WZ4002;N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide;WZ4002(HBr);N-{3-[(5-Chloro-2-{[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino}-4-pyriMidinyl)oxy]phenyl}acrylaMide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide WZ 4002;WZ 4002 N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide;N-[3-[5-chloro-2-[2-Methoxy-4-(4-Methylpiperazin-1-yl)anilino]pyriMidin-4-yl]oxyphenyl]prop-2-enaMide
28 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TRC
Package
- 100mg
- 250mg
- 1g
- 5g
- 10mM(in 1mL DMSO)
- 1unit
- 5mg
- 10MG
- 50MG
- ManufacturerAK Scientific
- Product numberX7482
- Product descriptionWZ4002
- Packaging5mg
- Price$47
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004448
- Product descriptionWZ-4002 95.00%
- Packaging5MG
- Price$192.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004448
- Product descriptionWZ-4002 95.00%
- Packaging10MG
- Price$226.8
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004448
- Product descriptionWZ-4002 95.00%
- Packaging50MG
- Price$981.75
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1389
- Product descriptionWZ4002
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1389
- Product descriptionWZ4002
- Packaging10mM(in 1mL DMSO)
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1389
- Product descriptionWZ4002
- Packaging10mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1389
- Product descriptionWZ4002
- Packaging50mg
- Price$260
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1389
- Product descriptionWZ4002
- Packaging100mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60094
- Product descriptionWZ4002 ≥98%
- Packaging10mg
- Price$168
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180821
- Product descriptionWZ4002 >99%
- Packaging100mg
- Price$414.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180821
- Product descriptionWZ4002 >99%
- Packaging250mg
- Price$555.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180821
- Product descriptionWZ4002 >99%
- Packaging1g
- Price$1060.8
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16297
- Product descriptionWZ4002 ≥98%
- Packaging5mg
- Price$62
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16297
- Product descriptionWZ4002 ≥98%
- Packaging10mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16297
- Product descriptionWZ4002 ≥98%
- Packaging50mg
- Price$419
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7482 | WZ4002 | 5mg | $47 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004448 | WZ-4002 95.00% | 5MG | $192.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004448 | WZ-4002 95.00% | 10MG | $226.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004448 | WZ-4002 95.00% | 50MG | $981.75 | 2021-12-16 | Buy |
| ApexBio Technology | A1389 | WZ4002 | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A1389 | WZ4002 | 10mM(in 1mL DMSO) | $75 | 2021-12-16 | Buy |
| ApexBio Technology | A1389 | WZ4002 | 10mg | $85 | 2021-12-16 | Buy |
| ApexBio Technology | A1389 | WZ4002 | 50mg | $260 | 2021-12-16 | Buy |
| ApexBio Technology | A1389 | WZ4002 | 100mg | $470 | 2021-12-16 | Buy |
| Arctom | CFN60094 | WZ4002 ≥98% | 10mg | $168 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180821 | WZ4002 >99% | 100mg | $414.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180821 | WZ4002 >99% | 250mg | $555.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180821 | WZ4002 >99% | 1g | $1060.8 | 2021-12-16 | Buy |
| Cayman Chemical | 16297 | WZ4002 ≥98% | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 16297 | WZ4002 ≥98% | 10mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 16297 | WZ4002 ≥98% | 50mg | $419 | 2024-03-01 | Buy |
Properties
Density :1.314
storage temp. :Store at -20°C
solubility :≥24.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :12.78±0.70(Predicted)
storage temp. :Store at -20°C
solubility :≥24.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :12.78±0.70(Predicted)
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
The recurrent missense mutation T790M in the kinase domain of epidermal growth factor receptor (EGFR) is a gatekeeper mutation, as it sterically hinders binding of inhibitors while preserving catalytic activity. WZ4002 is an irreversible EGFR tyrosine kinase inhibitor that blocks ATP-dependent autophosphorylation of EGFR carrying the T790M mutation as well as an L858R mutation (IC50 = 8 nM). It preferentially targets cells expressing EGFRT790M over those expressing EGFR without the T790M mutation. WZ4002 is also bioavailable in vivo when given intravenously and is effective in mouse models of lung cancer driven by EGFRT790M. Efficacy may be enhanced when used in combination therapy with inhibitors of Met kinase activity, Bcl-2, or histone deacetylases.Related product price
- WZ8040
$120-10100 - 1223397-11-2
$49-900 - Erlotinib hydrochloride
$5-3498.6
Suppliers and manufacturers
Nanjing Gold Pharmaceutical Technology Co. Ltd.
Beijing Cooperate Pharmaceutical Co.,Ltd
Nanjing Finetech Chemical Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Biochempartner
BOC Sciences
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
