b-AP15
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- $17 - $1300
- Product name: b-AP15
- CAS: 1009817-63-3
- MF: C22H17N3O6
- MW: 419.39
- EINECS:
- MDL Number:MFCD26142662
- Synonyms:b-AP15 (NSC687852);4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-, (3E,5E)-;NSC 687852 (b-AP15);LM-3077;(3E,5E)-3,5-Bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-4-piperidinone;(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one;(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-4-piperidinone;(3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one
59 prices
Selected condition：
Brand
- aablocks
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biosynth
- BroadPharm
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Synthonix
- TRC
Package
- 10mM(1mLinDMSO)
- 1mg
- 5mg
- 10mM(in 1mL DMSO)
- 10mg
- 25mg
- 50mg
- 100mg
- 10mM(in1mLDMSO)
- 200mg
- 250mg
- 500mg
- 1g
- Manufactureraablocks
- Product numberAA00039T
- Product descriptionb-AP15 98%
- Packaging1mg
- Price$17
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA00039T
- Product descriptionb-AP15 98%
- Packaging5mg
- Price$24
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA00039T
- Product descriptionb-AP15 98%
- Packaging10mg
- Price$38
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA00039T
- Product descriptionb-AP15 98
- Packaging25mg
- Price$92
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA00039T
- Product descriptionb-AP15 98
- Packaging50mg
- Price$127
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA00039T
- Product descriptionb-AP15 98
- Packaging100mg
- Price$200
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA00039T
- Product descriptionb-AP15 98
- Packaging200mg
- Price$338
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA00039T
- Product descriptionb-AP15 98
- Packaging500mg
- Price$561
- Updated2026-05-25
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3552-M005
- Product descriptionb-AP15 ≥98%
- Packaging5mg
- Price$80
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3552-M001
- Product descriptionb-AP15 ≥98%
- Packaging1mg
- Price$40
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number2249AH
- Product description(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one
- Packaging5mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA619221
- Product descriptionb-AP15 98+%
- Packaging25mg
- Price$114
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA619221
- Product descriptionb-AP15 98+%
- Packaging5mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA619221
- Product descriptionb-AP15 98+%
- Packaging10mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4453
- Product descriptionNSC687852(b-AP15)
- Packaging10mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4453
- Product descriptionNSC 687852 (b-AP15)
- Packaging10mg
- Price$83
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00039T | b-AP15 98% | 1mg | $17 | 2026-05-25 | Buy |
| aablocks | AA00039T | b-AP15 98% | 5mg | $24 | 2026-05-25 | Buy |
| aablocks | AA00039T | b-AP15 98% | 10mg | $38 | 2026-05-25 | Buy |
| aablocks | AA00039T | b-AP15 98 | 25mg | $92 | 2026-05-25 | Buy |
| aablocks | AA00039T | b-AP15 98 | 50mg | $127 | 2026-05-25 | Buy |
| aablocks | AA00039T | b-AP15 98 | 100mg | $200 | 2026-05-25 | Buy |
| aablocks | AA00039T | b-AP15 98 | 200mg | $338 | 2026-05-25 | Buy |
| aablocks | AA00039T | b-AP15 98 | 500mg | $561 | 2026-05-25 | Buy |
| Adipogen Life Sciences | AG-CR1-3552-M005 | b-AP15 ≥98% | 5mg | $80 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3552-M001 | b-AP15 ≥98% | 1mg | $40 | 2026-05-06 | Buy |
| AK Scientific | 2249AH | (3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one | 5mg | $105 | 2021-12-16 | Buy |
| Ambeed | A619221 | b-AP15 98+% | 25mg | $114 | 2021-12-16 | Buy |
| Ambeed | A619221 | b-AP15 98+% | 5mg | $39 | 2021-12-16 | Buy |
| Ambeed | A619221 | b-AP15 98+% | 10mg | $65 | 2021-12-16 | Buy |
| ApexBio Technology | A4453 | NSC687852(b-AP15) | 10mg | $75 | 2021-12-16 | Buy |
| ApexBio Technology | A4453 | NSC 687852 (b-AP15) | 10mg | $83 | 2026-05-06 | Buy |
Properties
Boiling point :670.4±55.0 °C(Predicted)
Density :1.416±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 35 mg/ml).
form :solid
pka :-1.58±0.20(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI :1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+
InChIKey :GFARQYQBWJLZMW-JYFOCSDGSA-N
SMILES :O=C(/C(CN(C(C=C)=O)C/1)=C/C(C=C2)=CC=C2[N+]([O-])=O)C1=C\C3=CC=C(C=C3)[N+]([O-])=O
Density :1.416±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 35 mg/ml).
form :solid
pka :-1.58±0.20(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI :1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+
InChIKey :GFARQYQBWJLZMW-JYFOCSDGSA-N
SMILES :O=C(/C(CN(C(C=C)=O)C/1)=C/C(C=C2)=CC=C2[N+]([O-])=O)C1=C\C3=CC=C(C=C3)[N+]([O-])=O
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
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| Precautionary statements: |
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Description
Proteasome-associated deubiquitinases (DUBs) release ubiquitin from proteasome-targeted ubiquitinated proteins, regenerating free ubiquitin. b-AP15 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs. It inhibits DUB activity in purified 19S proteasomes with an IC50 value of 2.1 μM. It exhibits little or no activity against several other DUBs. Through its effects on USP14 and UCHL5, b-AP15 blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia. b-AP15 also renders tumor cells sensitive to TNF-mediated apoptosis by natural killer and T cells.More related product prices
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
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