iKIX1
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- $28 - $650
- Product name: iKIX1
- CAS: 656222-54-7
- MF: C10H8Cl2N4OS
- MW: 303.17
- EINECS:
- MDL Number:MFCD00119122
- Synonyms:iKIX1;2-Cyano-N-{[(3,4-dichlorophenyl)carbamothioyl]amino}acetamide;antifungal,Inhibitor,drug-resistant,Fungal,CgGal11A,CgPdr1,infection,C. glabrata,iKIX1,inhibit,iKIX-1,iKIX 1;Acetic acid, 2-cyano-, 2-[[(3,4-dichlorophenyl)amino]thioxomethyl]hydrazide;Ikixi;iKIX1, 10 mM in DMSO;iKIX1 试剂
10 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
Package
- 500μg
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product number1523CJ
- Product description2-Cyano-N-{[(3,4-dichlorophenyl)carbamothioyl]amino}acetamide
- Packaging5mg
- Price$370
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19839
- Product descriptioniKIX1
- Packaging500μg
- Price$28
- Updated2023-01-06
- Buy
- ManufacturerCayman Chemical
- Product number19839
- Product descriptioniKIX1
- Packaging1mg
- Price$50
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19839
- Product descriptioniKIX1
- Packaging5mg
- Price$238
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19839
- Product descriptioniKIX1
- Packaging10mg
- Price$450
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0089717
- Product descriptioniKIX1
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0089717
- Product descriptioniKIX1
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0089717
- Product descriptioniKIX1
- Packaging25mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0089717
- Product descriptioniKIX1
- Packaging50mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0089717
- Product descriptioniKIX1
- Packaging100mg
- Price$650
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1523CJ | 2-Cyano-N-{[(3,4-dichlorophenyl)carbamothioyl]amino}acetamide | 5mg | $370 | 2021-12-16 | Buy |
| Cayman Chemical | 19839 | iKIX1 | 500μg | $28 | 2023-01-06 | Buy |
| Cayman Chemical | 19839 | iKIX1 | 1mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 19839 | iKIX1 | 5mg | $238 | 2024-03-01 | Buy |
| Cayman Chemical | 19839 | iKIX1 | 10mg | $450 | 2024-03-01 | Buy |
| ChemScene | CS-0089717 | iKIX1 | 5mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-0089717 | iKIX1 | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0089717 | iKIX1 | 25mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-0089717 | iKIX1 | 50mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0089717 | iKIX1 | 100mg | $650 | 2021-12-16 | Buy |
Properties
Density :1.551±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: soluble
form :A crystalline solid
pka :3.76±0.10(Predicted)
color :Off-white to light yellow
storage temp. :Store at -20°C
solubility :DMSO: soluble
form :A crystalline solid
pka :3.76±0.10(Predicted)
color :Off-white to light yellow
Safety Information
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Description
iKIX1 is an inhibitor of interactions between the transcription co-activator Mediator complex and the pleitropic drug resistance (CgPdr1) transcription factor in the pathogen C. glabrata. It inhibits the interaction between the KIX domain of the Mediator subunit CgGal11A and the activation domain of CgPdr1 (IC50 = 190.2 μM). iKIX1 (10 and 30 μM) inhibits ketoconazole-induced expression of CgPdr1-target genes involved in multidrug resistance and drug efflux in C. glabrata. It increases the sensitivity of azole-resistant C. glabrata strains expressing CgPDR1 gain-of-function mutations to the antifungal compounds fluconazole and ketoconazole in a concentration-dependent manner. iKIX1 (100 mg/kg) decreases fungal burden in the kidney and spleen in a mouse model of infection with azole-sensitive or -resistant C. glabrata when administered in combination with low and high doses of fluconazole, respectively.Suppliers and manufacturers
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MedBioPharmaceutical Technology Inc
