kukoamine A
|
- $38 - $1490
- Product name: kukoamine A
- CAS: 75288-96-9
- MF: C28H42N4O6
- MW: 530.66
- EINECS:
- MDL Number:MFCD29904538
- Synonyms:kukoamine A;1,14-Bis(dihydrocaffeoyl)spermidine;N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxybenzenepropanamide];N,N'-[Tetramethylenebis(iminotrimethylene)]bis[3-(3,4-dihydroxyphenyl)propionamide];N1,N12-Bis(dihydrocaffeoyl) spermine;Benzenepropanamide,N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-;N,N'-((butane-1,4-diylbis(azanediyl))bis(propane-3,1-diyl))bis(3-(3,4-dihydroxyphenyl)propanamide);NSC 5398
22 prices
Selected condition：
Brand
- AK Scientific
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- Usbiological
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 20mg
- 100mg
- ManufacturerAK Scientific
- Product number9624AF
- Product descriptionKukoamineA
- Packaging1mg
- Price$139
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN93215
- Product descriptionKukoamineA ≥98%
- Packaging10mg
- Price$410
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberSY232515
- Product descriptionKukoamineA ≥98%
- Packaging20mg
- Price$1030.91
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3257
- Product descriptionKukoamine A
- Packaging1mg
- Price$89
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3257
- Product descriptionKukoamine A
- Packaging5mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3257
- Product descriptionKukoamine A
- Packaging10mg
- Price$289
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3257
- Product descriptionKukoamine A
- Packaging20mg
- Price$489
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3257
- Product descriptionKukoamine A
- Packaging100mg
- Price$1490
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb259342
- Product descriptionKukoamine A 98%
- Packaging5mg
- Price$433.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb259342
- Product descriptionKukoamine A 98%
- Packaging10mg
- Price$596.7
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFK74515
- Product descriptionKukoamine A
- Packaging1mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFK74515
- Product descriptionKukoamine A
- Packaging2mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFK74515
- Product descriptionKukoamine A
- Packaging5mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFK74515
- Product descriptionKukoamine A
- Packaging10mg
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFK74515
- Product descriptionKukoamine A
- Packaging20mg
- Price$1000
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number25139
- Product descriptionKukoamine A ≥95%
- Packaging1mg
- Price$38
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 9624AF | KukoamineA | 1mg | $139 | 2021-12-16 | Buy |
| Arctom | CFN93215 | KukoamineA ≥98% | 10mg | $410 | 2021-12-16 | Buy |
| Arctom | SY232515 | KukoamineA ≥98% | 20mg | $1030.91 | 2021-12-16 | Buy |
| AvaChem | 3257 | Kukoamine A | 1mg | $89 | 2021-12-16 | Buy |
| AvaChem | 3257 | Kukoamine A | 5mg | $189 | 2021-12-16 | Buy |
| AvaChem | 3257 | Kukoamine A | 10mg | $289 | 2021-12-16 | Buy |
| AvaChem | 3257 | Kukoamine A | 20mg | $489 | 2021-12-16 | Buy |
| AvaChem | 3257 | Kukoamine A | 100mg | $1490 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259342 | Kukoamine A 98% | 5mg | $433.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259342 | Kukoamine A 98% | 10mg | $596.7 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FK74515 | Kukoamine A | 1mg | $300 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FK74515 | Kukoamine A | 2mg | $450 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FK74515 | Kukoamine A | 5mg | $600 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FK74515 | Kukoamine A | 10mg | $800 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FK74515 | Kukoamine A | 20mg | $1000 | 2021-12-16 | Buy |
| Cayman Chemical | 25139 | Kukoamine A ≥95% | 1mg | $38 | 2024-03-01 | Buy |
Properties
Boiling point :872.1±65.0 °C(Predicted)
Density :1.213±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form :A crystalline solid
pka :9.48±0.10(Predicted)
color :Off-white to yellow
InChIKey :IOLDDENZPBFBHV-UHFFFAOYSA-N
SMILES :C(NCCCNC(=O)CCC1=CC=C(O)C(O)=C1)CCCNCCCNC(=O)CCC1=CC=C(O)C(O)=C1
CAS DataBase Reference :75288-96-9
Density :1.213±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form :A crystalline solid
pka :9.48±0.10(Predicted)
color :Off-white to yellow
InChIKey :IOLDDENZPBFBHV-UHFFFAOYSA-N
SMILES :C(NCCCNC(=O)CCC1=CC=C(O)C(O)=C1)CCCNCCCNC(=O)CCC1=CC=C(O)C(O)=C1
CAS DataBase Reference :75288-96-9
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Kukoamine A is a spermine alkaloid originally isolated from L. chinense that has diverse biological activities, including anticancer, neuroprotective, and anti-inflammatory properties. Kukoamine A (5-20 μg/ml) inhibits colony formation of U251 and WJ1 glioblastoma cells in a concentration-dependent manner. It halts the cell cycle at the G0/G1 phase and induces apoptosis when used at concentrations of 60 and 80 μg/ml. Kukoamine A (20 and 40 μM) induces autophagy and increases cell viability in an SH-SY5Y cell model of MPP-induced injury. It increases the number of dopamine neurons in the substantia nigra and striatum, decreases α-synuclein expression, and improves motor function in an MPTP mouse model of Parkinson’s disease when administered at a dose of 20 mg/kg per day. Kukoamine A (10 and 20 mg/kg) decreases IL-1β, TNF-α, and COX-2 protein levels in the hippocampus and increases hippocampal neurogenesis in a rat model of radiation injury. It also selectively inhibits trypanothione reductase (Ki = 1.8 μM), an enzyme that protects certain parasites from oxidative stress, over human glutathione reductase (Ki = >10 mM).More related product prices
KukoaMine B CALYCOSIN (-)-Huperzine A Tributyl citrate 7226-23-5 daurisoline L-Hyoscyamine VERATRIDINE Triptolide veratramine VERATRINE SpermidineRelated product price
- KukoaMine B
$36-1191.7 - CALYCOSIN
$40-1200 - (-)-Huperzine A
$28-2500
