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ChemicalBook >> CAS DataBase List >> Triptolide

Triptolide

Triptolide price.
  • $32 - $2097.8
  • Product name: Triptolide
  • CAS: 38748-32-2
  • MF: C20H24O6
  • MW: 360.4
  • EINECS:683-214-2
  • MDL Number:MFCD00210565
  • Synonyms:TRIPTOLIDE;TRIPTOLIDE, TRIPTERYGIUM WILFORDII;,7as,7bs,8as,8bs)- ;triptolid ;Triptolide, >=98%;TriptolidefromTripterygium wilfordii≥ 98% (HPLC);Triptolide(TPL);TRIPTOLIDE TLC
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Brand

  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • BroadPharm
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • JR MediChem
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological

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  • 1MG
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  • 10mg
  • 20mg
  • 25MG
  • 50mg
  • 100mg
  • 250mg
  • 10mM(in 1mL DMSO)
  • 1g
  • 25 mg
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0448-M005
  • Product descriptionTriptolide ≥98%(HPLC)
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ98592
  • Product descriptionTriptolide
  • Packaging100mg
  • Price$790
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0004843
  • Product descriptionTRIPTOLIDE 95.00%
  • Packaging1MG
  • Price$134.4
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0004843
  • Product descriptionTRIPTOLIDE 95.00%
  • Packaging25MG
  • Price$1871.1
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3891
  • Product descriptionTriptolide
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3891
  • Product descriptionTriptolide
  • Packaging10mM(in 1mL DMSO)
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3891
  • Product descriptionTriptolide
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3891
  • Product descriptionTriptolide
  • Packaging25mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3891
  • Product descriptionTriptolide
  • Packaging1g
  • Price$1800
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIA8418
  • Product descriptionTriptolide
  • Packaging1mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberSY034862
  • Product descriptionTriptolide
  • Packaging10mg
  • Price$159.55
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN99196
  • Product descriptionTriptolide
  • Packaging20mg
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1892
  • Product descriptionTriptolide
  • Packaging5mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1892
  • Product descriptionTriptolide
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1892
  • Product descriptionTriptolide
  • Packaging25mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1892
  • Product descriptionTriptolide
  • Packaging100mg
  • Price$380
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CN2-0448-M005 Triptolide ≥98%(HPLC) 5mg $90 2021-12-16 Buy
AK Scientific J98592 Triptolide 100mg $790 2021-12-16 Buy
American Custom Chemicals Corporation PXT0004843 TRIPTOLIDE 95.00% 1MG $134.4 2021-12-16 Buy
American Custom Chemicals Corporation PXT0004843 TRIPTOLIDE 95.00% 25MG $1871.1 2021-12-16 Buy
ApexBio Technology A3891 Triptolide 5mg $70 2021-12-16 Buy
ApexBio Technology A3891 Triptolide 10mM(in 1mL DMSO) $100 2021-12-16 Buy
ApexBio Technology A3891 Triptolide 10mg $120 2021-12-16 Buy
ApexBio Technology A3891 Triptolide 25mg $240 2021-12-16 Buy
ApexBio Technology A3891 Triptolide 1g $1800 2021-12-16 Buy
Apolloscientific BIA8418 Triptolide 1mg $80 2021-12-16 Buy
Arctom SY034862 Triptolide 10mg $159.55 2021-12-16 Buy
Arctom CFN99196 Triptolide 20mg $138 2021-12-16 Buy
AvaChem 1892 Triptolide 5mg $45 2021-12-16 Buy
AvaChem 1892 Triptolide 10mg $85 2021-12-16 Buy
AvaChem 1892 Triptolide 25mg $145 2021-12-16 Buy
AvaChem 1892 Triptolide 100mg $380 2021-12-16 Buy

Properties

Melting point :226-227°C
alpha :D25 -154°
Boiling point :412.43°C (rough estimate)
Density :1.1656 (rough estimate)
refractive index :1.4450 (estimate)
storage temp. :2-8°C
solubility :DMSO: soluble
form :solid
pka :14.25±0.60(Predicted)
color :white to off-white
Merck :14,9747
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :DFBIRQPKNDILPW-CIVMWXNOSA-N
CAS DataBase Reference :38748-32-2(CAS DataBase Reference)
EPA Substance Registry System :Trisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)- (38748-32-2)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.

Description

Triptolide is the major bioactive constituent of T. wilfordii Hook F., also known as thunder god vine, a traditional Chinese medicinal herb with known antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and anti-polycystic kidney disease effects. Triptolide binds to and inhibits human dCTP pyrophosphatase 1, a “gatekeeper” enzyme that prevents deleterious halogenated nucleotides from entering DNA synthesis, with a Ki value of 168 μM and an IC50 value of 7-10 nM. Triptolide has also been shown to inhibit LPS-stimulated induction of cyclooxygenase 2 mRNA and synthesis of prostaglandin E2 in human peripheral blood monocytes, rheumatoid arthritis synovial fibroblasts, and human neonatal foreskin fibroblasts with an IC50 value of 0.04 μM.

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