N-ブチルデオキシノジリマイシン塩酸塩
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- ￥59700 - ￥390500
- 化学名: N-ブチルデオキシノジリマイシン塩酸塩
- 英語名: N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE
- 別名:N-ブチルデオキシノジリマイシン塩酸塩
- CAS番号: 210110-90-0
- 分子式: C10H22ClNO4
- 分子量: 255.74
- EINECS:
- MDL Number:MFCD00269940
3物価
選択条件：
ブランド
- 富士フイルム和光純薬株式会社(wako)
パッケージ
- 10mg
- 100mg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TRCB691000
- 製品説明N-ブチルデオキシノジリマイシン塩酸塩
- 英語製品説明N-Butyldeoxynojirimycin Hydrochloride
- 包装単位10mg
- 価格￥59700
- 更新しました2024-03-01
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC3117
- 製品説明
- 英語製品説明Miglustat hydrochloride
- 包装単位10mg
- 価格￥80000
- 更新しました2024-03-01
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TRCB691000
- 製品説明N-ブチルデオキシノジリマイシン塩酸塩
- 英語製品説明N-Butyldeoxynojirimycin Hydrochloride
- 包装単位100mg
- 価格￥390500
- 更新しました2023-06-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式会社(wako) | W01TRCB691000 | N-ブチルデオキシノジリマイシン塩酸塩 N-Butyldeoxynojirimycin Hydrochloride |
10mg | ￥59700 | 2024-03-01 | 購入 |
| 富士フイルム和光純薬株式会社(wako) | W01TOC3117 | Miglustat hydrochloride |
10mg | ￥80000 | 2024-03-01 | 購入 |
| 富士フイルム和光純薬株式会社(wako) | W01TRCB691000 | N-ブチルデオキシノジリマイシン塩酸塩 N-Butyldeoxynojirimycin Hydrochloride |
100mg | ￥390500 | 2023-06-01 | 購入 |
プロパティ
融点 :169-172°C
貯蔵温度 :Inert atmosphere,Room Temperature
溶解性 :Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
外見 :White to off-white solid.
色 :White
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
貯蔵温度 :Inert atmosphere,Room Temperature
溶解性 :Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
外見 :White to off-white solid.
色 :White
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
安全情報
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説明
N-ButyldeoxynojirimycinHCl is a novel inhibitor of UGCG (glucosylceramide synthase) as well as Glucosidase I and II (α-glucosidase I and II). The compound has been shown to inhibit glucosylceramide synthase without ceramide accumulation and cell death. When administered to young mice the compound reduced glycosphingolipid production 50%-70% in the liver and lymphoid organs without any overt pathology. It is a potent inhibitor of HIV virus replication and syncytium formation in vitro. The compound has been observed to restore cAMP-activated chloride currents in epithelial cystic fibrosis cells through prevented interaction among calnexin and delF508-CFTR. In a mice model for Tay Sachs disease, mice exposed to N-ButyldeoxynojirimycinHCl limited the biosynthesis of GM2 thus preventing accumulation of GM2 in the brain and glycosphingolipids. This action markedly reduced the number of storage neurons and gangliosides per cell. N-ButyldeoxynojirimycinHCl has also rescued trafficking-deficient F508del-CTFR in human airway epithelial cells via inhibition of ER-glucosidases I and II. Also has broad spectrum antiviral activity.関連商品価格
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