PRL-3 INHIBITOR I
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1物価
選択条件：
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 生産者Sigma-Aldrich Japan
- 製品番号P0108
- 製品説明 ≥98% (HPLC), solid
- 英語製品説明PRL-3 Inhibitor I ≥98% (HPLC), solid
- 包装単位5mg
- 価格￥19900
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| Sigma-Aldrich Japan | P0108 | ≥98% (HPLC), solid PRL-3 Inhibitor I ≥98% (HPLC), solid |
5mg | ￥19900 | 2024-03-01 | 購入 |
プロパティ
比重(密度) :1.85±0.1 g/cm3(Predicted)
貯蔵温度 :−20°C
溶解性 :DMSO: >10mg/mL
外見 :Yellow solid
酸解離定数(Pka) :7.11±0.50(Predicted)
色 :yellow
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
貯蔵温度 :−20°C
溶解性 :DMSO: >10mg/mL
外見 :Yellow solid
酸解離定数(Pka) :7.11±0.50(Predicted)
色 :yellow
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
安全情報
| 絵表示(GHS): |
 
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説明
Phosphatase of regenerating liver 3 (PRL-3; also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50 = 900 nM for human PRL-3 in vitro), with minimal activity against other phosphatases. It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay. PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin β1 and modulates VEGF-mediated endothelial cell migration. It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines.関連商品価格
- 2-(4-ピリジニルメチルアミノ)-N-[3-(トリフルオロメチル)フェニル]ベンズアミド
￥20600-495800 - 3-[[[3-[(E)-2-(7-クロロキノリン-2-イル)エテニル]フェニル][[3-(ジメチルアミノ)-3-オキソプロピル]チオ]メチル]チオ]プロパン酸
￥24900-150200 - CL 82198 HYDROCHLORIDE
￥14100-65700
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