380917-97-5 Basic information More..
Product Name:PeraMpanel
Synonyms:3-(2-Cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one;3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one;2-(2-oxo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile;2-(6'-Oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile;Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)-;ER 155055-90 Perampanel;Perampane;2-(2-oxo-1-phenyl-5-pyridin-2- ylpyridin-3-yl)benzonitrile
CAS:380917-97-5
MF:C23H15N3O
MW:349.38
EINECS:691-969-4
Mol File:380917-97-5.mol
380917-97-5

Use

With AEDs Some AEDs known as CYP450 3A enzyme inducers (carbamazepine, oxcarbazepine, phenytoin) have been shown to increase perampanel clearance and consequently to decrease plasma concentrations of perampanel. Carbamazepine, a known potent enzyme inducer, reduced perampanel levels by two- thirds in a study performed on healthy subjects In the epilepsy population pharmacokinetic analysis, perampanel was found to decrease the clearance of oxcarbazepine by 26%. Oxcarbazepine is rapidly metabolized by cytosolic reductase enzyme to the active metabolite, monohydroxycarbazepine. The effect of perampanel on monohydroxycarbazepine concentrations is not known. With other drugs Strong inducers of cytochrome P450, such as rifampicin and St Johns Wort (Hypericum perforatum), are expected to decrease perampanel concentrations. In healthy subjects, the CYP3A4 inhibitor ketoconazole increases perampanel exposure. Perampanel can make certain hormonal contraceptives such as levonorgestrel less effective. Decrease in exposure of midazolam may be caused by perampanel. With alcohol/food Drinking alcohol while taking perampanel can affect a patients alertness and ability to drive or use tools or machines. It can also aggravate irritability, confusion, and depression. There are no specific foods that must be excluded from diet when taking perampanel.

Lastest Price from PeraMpanel manufacturers

  • Perampanel
  • US $15.00-10.00 / KG
  • 2021-07-13
  • CAS:380917-97-5
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Perampanel
  • US $15.00-10.00 / KG
  • 2021-07-10
  • CAS:380917-97-5
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • PeraMpanel
  • US $7.00 / KG
  • 2019-09-02
  • CAS: 380917-97-5
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: JD 474
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