| | 1187460-81-6 Basic information More.. |
| Product Name: | PF 184 | | Synonyms: | PF 184;8-[[[5-Chloro-2-[3,4-diMethyl-3,4-bis(hydroxyMethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]aMino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxaMide;1H-Benz[g]indazole-3-carboxamide, 8-[[[2-[3,4-bis(hydroxymethyl)-3,4-dimethyl-1-pyrrolidinyl]-5-chloro-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro- | | CAS: | 1187460-81-6 | | MF: | C32H32ClFN6O4 | | MW: | 619.09 | | EINECS: | | | Mol File: | 1187460-81-6.mol |  |
Use
PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress.
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1187460-81-6
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